FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308370897> ?p ?o ?g. }

• W4308370897 endingPage "629" @default.
• W4308370897 startingPage "617" @default.
• W4308370897 abstract "The aim of this study is to assess clinical efficacy of ceftazidime-avibactam for the management of carbapenem-resistant Gram-negative infections in renal patients receiving recommended dosing adjustments compared to those treated with scheduled full-dose.Two authors independently searched PubMed-MEDLINE and Scopus database from inception to 31 December 2021, to retrieve randomized controlled trials or observational studies comparing clinical efficacy of ceftazidime-avibactam in patients affected by carbapenem-resistant Gram-negative infections receiving recommended renal dosing adjustments compared to those treated with scheduled full-dose. Data were independently extracted by the 2 authors, and the quality of included studies was independently assessed according to ROBINS-I tool for observational studies. Mortality rate was selected as primary outcome. Meta-analysis was conducted by including only studies at low or moderate risk of bias providing adjustment for confounders.In total, 1794 articles were screened, and 11 observational studies (1 prospective and 10 retrospective) were included. Serious or critical risk of bias was found in 4 studies, while the other 7 were classified at moderate risk of bias and included in the meta-analysis. Renal dosing adjustments of ceftazidime-avibactam were associated with higher risk of mortality (odds ratio 1.79; 95% confidence interval 1.18-2.72).Renal dosing adjustment of ceftazidime-avibactam seems to be associated with a higher risk of mortality in patients affected by carbapenem-resistant Gram-negative infections. However, residual confounder associated with baseline conditions cannot be excluded. Further prospective studies including larger samples are warranted to definitively address this unmet clinical need." @default.
• W4308370897 created "2022-11-11" @default.
• W4308370897 creator A5037784764 @default.
• W4308370897 creator A5040568455 @default.
• W4308370897 creator A5045135007 @default.
• W4308370897 creator A5061691353 @default.
• W4308370897 creator A5071687756 @default.
• W4308370897 date "2022-11-22" @default.
• W4308370897 modified "2023-10-14" @default.
• W4308370897 title "Clinical efficacy of renal dosing adjustments of ceftazidime–avibactam in patients affected by carbapenem‐resistant Gram‐negative infections: A systematic review and meta‐analysis of observational studies" @default.
• W4308370897 cites W2157823046 @default.
• W4308370897 cites W2294833633 @default.
• W4308370897 cites W2435544242 @default.
• W4308370897 cites W2531269403 @default.
• W4308370897 cites W2892028816 @default.
• W4308370897 cites W2894551919 @default.
• W4308370897 cites W2987002164 @default.
• W4308370897 cites W2991949326 @default.
• W4308370897 cites W3039174242 @default.
• W4308370897 cites W3099341478 @default.
• W4308370897 cites W3110797353 @default.
• W4308370897 cites W3118615836 @default.
• W4308370897 cites W3126415404 @default.
• W4308370897 cites W3133086699 @default.
• W4308370897 cites W3133574075 @default.
• W4308370897 cites W3210551305 @default.
• W4308370897 cites W4226277588 @default.
• W4308370897 cites W4245505926 @default.
• W4308370897 doi "https://doi.org/10.1111/bcp.15586" @default.
• W4308370897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36337045" @default.
• W4308370897 hasPublicationYear "2022" @default.
• W4308370897 type Work @default.
• W4308370897 citedByCount "3" @default.
• W4308370897 countsByYear W43083708972023 @default.
• W4308370897 crossrefType "journal-article" @default.
• W4308370897 hasAuthorship W4308370897A5037784764 @default.
• W4308370897 hasAuthorship W4308370897A5040568455 @default.
• W4308370897 hasAuthorship W4308370897A5045135007 @default.
• W4308370897 hasAuthorship W4308370897A5061691353 @default.
• W4308370897 hasAuthorship W4308370897A5071687756 @default.
• W4308370897 hasConcept C126322002 @default.
• W4308370897 hasConcept C156957248 @default.
• W4308370897 hasConcept C168563851 @default.
• W4308370897 hasConcept C177713679 @default.
• W4308370897 hasConcept C23131810 @default.
• W4308370897 hasConcept C2775933652 @default.
• W4308370897 hasConcept C2776685102 @default.
• W4308370897 hasConcept C2776968632 @default.
• W4308370897 hasConcept C2777288759 @default.
• W4308370897 hasConcept C2777406300 @default.
• W4308370897 hasConcept C2777637488 @default.
• W4308370897 hasConcept C44249647 @default.
• W4308370897 hasConcept C501593827 @default.
• W4308370897 hasConcept C523546767 @default.
• W4308370897 hasConcept C54355233 @default.
• W4308370897 hasConcept C71924100 @default.
• W4308370897 hasConcept C77350462 @default.
• W4308370897 hasConcept C86803240 @default.
• W4308370897 hasConcept C89423630 @default.
• W4308370897 hasConcept C95190672 @default.
• W4308370897 hasConceptScore W4308370897C126322002 @default.
• W4308370897 hasConceptScore W4308370897C156957248 @default.
• W4308370897 hasConceptScore W4308370897C168563851 @default.
• W4308370897 hasConceptScore W4308370897C177713679 @default.
• W4308370897 hasConceptScore W4308370897C23131810 @default.
• W4308370897 hasConceptScore W4308370897C2775933652 @default.
• W4308370897 hasConceptScore W4308370897C2776685102 @default.
• W4308370897 hasConceptScore W4308370897C2776968632 @default.
• W4308370897 hasConceptScore W4308370897C2777288759 @default.
• W4308370897 hasConceptScore W4308370897C2777406300 @default.
• W4308370897 hasConceptScore W4308370897C2777637488 @default.
• W4308370897 hasConceptScore W4308370897C44249647 @default.
• W4308370897 hasConceptScore W4308370897C501593827 @default.
• W4308370897 hasConceptScore W4308370897C523546767 @default.
• W4308370897 hasConceptScore W4308370897C54355233 @default.
• W4308370897 hasConceptScore W4308370897C71924100 @default.
• W4308370897 hasConceptScore W4308370897C77350462 @default.
• W4308370897 hasConceptScore W4308370897C86803240 @default.
• W4308370897 hasConceptScore W4308370897C89423630 @default.
• W4308370897 hasConceptScore W4308370897C95190672 @default.
• W4308370897 hasIssue "2" @default.
• W4308370897 hasLocation W43083708971 @default.
• W4308370897 hasLocation W43083708972 @default.
• W4308370897 hasOpenAccess W4308370897 @default.
• W4308370897 hasPrimaryLocation W43083708971 @default.
• W4308370897 hasRelatedWork W2097533517 @default.
• W4308370897 hasRelatedWork W2114554564 @default.
• W4308370897 hasRelatedWork W2124369982 @default.
• W4308370897 hasRelatedWork W2152819796 @default.
• W4308370897 hasRelatedWork W2162716119 @default.
• W4308370897 hasRelatedWork W2549454559 @default.
• W4308370897 hasRelatedWork W2575028928 @default.
• W4308370897 hasRelatedWork W2810002446 @default.
• W4308370897 hasRelatedWork W3111122494 @default.
• W4308370897 hasRelatedWork W4285733344 @default.
• W4308370897 hasVolume "89" @default.
• W4308370897 isParatext "false" @default.
• W4308370897 isRetracted "false" @default.

• next