Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308372096> ?p ?o ?g. }
- W4308372096 endingPage "406" @default.
- W4308372096 startingPage "397" @default.
- W4308372096 abstract "Pharmacological treatments can extend the life span of mice. For optimal translation in humans, treatments should improve health during aging, and demonstrate efficacy when started later in life. Acarbose (ACA) and rapamycin (RAP) extend life span in mice when treatment is started early or later in life. Both drugs can also improve some indices of healthy aging, although there has been little systematic study of whether health benefits accrue differently depending on the age at which treatment is started. Here we compare the effects of early (4 months) versus late (16 months) onset ACA or RAP treatment on physical function and cardiac structure in genetically heterogeneous aged mice. ACA or RAP treatment improve rotarod acceleration and endurance capacity compared to controls, with effects that are largely similar in mice starting treatment from early or late in life. Compared to controls, cardiac hypertrophy is reduced by ACA or RAP in both sexes regardless of age at treatment onset. ACA has a greater effect on the cardiac lipidome than RAP, and the effects of early-life treatment are recapitulated by late-life treatment. These results indicate that late-life treatment with these drugs provide at least some of the benefits of life long treatment, although some of the benefits occur only in males, which could lead to sex differences in health outcomes later in life." @default.
- W4308372096 created "2022-11-11" @default.
- W4308372096 creator A5004475802 @default.
- W4308372096 creator A5009273755 @default.
- W4308372096 creator A5035005761 @default.
- W4308372096 creator A5043889297 @default.
- W4308372096 creator A5066597539 @default.
- W4308372096 creator A5083767342 @default.
- W4308372096 creator A5085663664 @default.
- W4308372096 creator A5087349635 @default.
- W4308372096 date "2022-11-07" @default.
- W4308372096 modified "2023-10-15" @default.
- W4308372096 title "Early or Late-Life Treatment With Acarbose or Rapamycin Improves Physical Performance and Affects Cardiac Structure in Aging Mice" @default.
- W4308372096 cites W1498875373 @default.
- W4308372096 cites W1978161786 @default.
- W4308372096 cites W1979033703 @default.
- W4308372096 cites W2001399616 @default.
- W4308372096 cites W2019041167 @default.
- W4308372096 cites W2025133084 @default.
- W4308372096 cites W2040213984 @default.
- W4308372096 cites W2048376025 @default.
- W4308372096 cites W2071801476 @default.
- W4308372096 cites W2080094749 @default.
- W4308372096 cites W2083342497 @default.
- W4308372096 cites W2086888830 @default.
- W4308372096 cites W2098437467 @default.
- W4308372096 cites W2100548432 @default.
- W4308372096 cites W2109870340 @default.
- W4308372096 cites W2137331540 @default.
- W4308372096 cites W2143112776 @default.
- W4308372096 cites W2148293249 @default.
- W4308372096 cites W2156003677 @default.
- W4308372096 cites W2156215703 @default.
- W4308372096 cites W2157360228 @default.
- W4308372096 cites W2223026269 @default.
- W4308372096 cites W2291642348 @default.
- W4308372096 cites W2408643388 @default.
- W4308372096 cites W2438502441 @default.
- W4308372096 cites W2516117533 @default.
- W4308372096 cites W2521232955 @default.
- W4308372096 cites W2588346480 @default.
- W4308372096 cites W2593816418 @default.
- W4308372096 cites W2601429121 @default.
- W4308372096 cites W2617310873 @default.
- W4308372096 cites W2663143820 @default.
- W4308372096 cites W2747486208 @default.
- W4308372096 cites W2807344333 @default.
- W4308372096 cites W2808140029 @default.
- W4308372096 cites W2890978227 @default.
- W4308372096 cites W2912297883 @default.
- W4308372096 cites W2914772541 @default.
- W4308372096 cites W2996589793 @default.
- W4308372096 cites W2998847910 @default.
- W4308372096 cites W3081052525 @default.
- W4308372096 cites W3090973681 @default.
- W4308372096 cites W3201197862 @default.
- W4308372096 cites W3209546556 @default.
- W4308372096 doi "https://doi.org/10.1093/gerona/glac221" @default.
- W4308372096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36342748" @default.
- W4308372096 hasPublicationYear "2022" @default.
- W4308372096 type Work @default.
- W4308372096 citedByCount "3" @default.
- W4308372096 countsByYear W43083720962023 @default.
- W4308372096 crossrefType "journal-article" @default.
- W4308372096 hasAuthorship W4308372096A5004475802 @default.
- W4308372096 hasAuthorship W4308372096A5009273755 @default.
- W4308372096 hasAuthorship W4308372096A5035005761 @default.
- W4308372096 hasAuthorship W4308372096A5043889297 @default.
- W4308372096 hasAuthorship W4308372096A5066597539 @default.
- W4308372096 hasAuthorship W4308372096A5083767342 @default.
- W4308372096 hasAuthorship W4308372096A5085663664 @default.
- W4308372096 hasAuthorship W4308372096A5087349635 @default.
- W4308372096 hasConcept C111566952 @default.
- W4308372096 hasConcept C126322002 @default.
- W4308372096 hasConcept C134018914 @default.
- W4308372096 hasConcept C2776617576 @default.
- W4308372096 hasConcept C2778198053 @default.
- W4308372096 hasConcept C2988516024 @default.
- W4308372096 hasConcept C42407357 @default.
- W4308372096 hasConcept C555293320 @default.
- W4308372096 hasConcept C71924100 @default.
- W4308372096 hasConcept C74909509 @default.
- W4308372096 hasConceptScore W4308372096C111566952 @default.
- W4308372096 hasConceptScore W4308372096C126322002 @default.
- W4308372096 hasConceptScore W4308372096C134018914 @default.
- W4308372096 hasConceptScore W4308372096C2776617576 @default.
- W4308372096 hasConceptScore W4308372096C2778198053 @default.
- W4308372096 hasConceptScore W4308372096C2988516024 @default.
- W4308372096 hasConceptScore W4308372096C42407357 @default.
- W4308372096 hasConceptScore W4308372096C555293320 @default.
- W4308372096 hasConceptScore W4308372096C71924100 @default.
- W4308372096 hasConceptScore W4308372096C74909509 @default.
- W4308372096 hasFunder F4320306228 @default.
- W4308372096 hasFunder F4320332161 @default.
- W4308372096 hasIssue "3" @default.
- W4308372096 hasLocation W43083720961 @default.
- W4308372096 hasLocation W43083720962 @default.
- W4308372096 hasOpenAccess W4308372096 @default.