Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308373389> ?p ?o ?g. }
- W4308373389 endingPage "788" @default.
- W4308373389 startingPage "771" @default.
- W4308373389 abstract "The steroid hormone 20-hydroxyecdysone (20E) has been described to regulate fat body lipid metabolism in insects, but its accurate regulatory mechanism, especially the crosstalk between 20E-induced lipid metabolism and gluconeogenesis remains largely unclear. Here, we specially investigated the effect of 20E on lipid metabolism and gluconeogenesis in the fat body of Hyphantria cunea larvae, a notorious pest in forestry. Lipidomics analysis showed that a total of 1 907 lipid species were identified in the fat body of H. cunea larvae assigned to 6 groups and 48 lipid classes. The differentially abundant lipids analysis showed a significant difference between 20E-treated and control samples, indicating that 20E caused a remarkable alteration of lipidomics profiles in the fat body of H. cunea larvae. Further studies demonstrated that 20E accelerated fatty acid β-oxidation, inhibited lipid synthesis, and promoted lipolysis. Meanwhile, the activities of pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose-1,6-bisphosphatase, and glucose-6-phosphatase were dramatically suppressed by 20E in the fat body of H. cunea larvae. As well, the transcriptions of genes encoding these 4 rate-limiting gluconeogenic enzymes were significantly downregulated in the fat body of H. cunea larvae after treatment with 20E. Taken together, our results revealed that 20E disturbed fat body lipid homeostasis, accelerated fatty acid β-oxidation and promoted lipolysis, but negatively regulated gluconeogenesis in H. cunea larvae. The findings might provide a new insight into hormonal regulation of glucose and lipid metabolism in insect fat body." @default.
- W4308373389 created "2022-11-11" @default.
- W4308373389 creator A5002391550 @default.
- W4308373389 creator A5004857519 @default.
- W4308373389 creator A5028995304 @default.
- W4308373389 creator A5038021915 @default.
- W4308373389 creator A5042916922 @default.
- W4308373389 creator A5058437368 @default.
- W4308373389 creator A5058780237 @default.
- W4308373389 creator A5059048284 @default.
- W4308373389 creator A5066135716 @default.
- W4308373389 creator A5086139839 @default.
- W4308373389 date "2022-12-07" @default.
- W4308373389 modified "2023-10-14" @default.
- W4308373389 title "Steroid hormone 20‐hydroxyecdysone disturbs fat body lipid metabolism and negatively regulates gluconeogenesis in <i>Hyphantria cunea</i> larvae" @default.
- W4308373389 cites W105515109 @default.
- W4308373389 cites W1922119015 @default.
- W4308373389 cites W1968882406 @default.
- W4308373389 cites W1977224357 @default.
- W4308373389 cites W1979217402 @default.
- W4308373389 cites W1985241942 @default.
- W4308373389 cites W1994142435 @default.
- W4308373389 cites W1996181056 @default.
- W4308373389 cites W2000047954 @default.
- W4308373389 cites W2009028852 @default.
- W4308373389 cites W2010188590 @default.
- W4308373389 cites W2011622414 @default.
- W4308373389 cites W2012257160 @default.
- W4308373389 cites W2015097206 @default.
- W4308373389 cites W2019125169 @default.
- W4308373389 cites W2042706232 @default.
- W4308373389 cites W2055148149 @default.
- W4308373389 cites W2094997711 @default.
- W4308373389 cites W2102819777 @default.
- W4308373389 cites W2107040485 @default.
- W4308373389 cites W2107277218 @default.
- W4308373389 cites W2107498496 @default.
- W4308373389 cites W2112668580 @default.
- W4308373389 cites W2112743993 @default.
- W4308373389 cites W2126002967 @default.
- W4308373389 cites W2142112444 @default.
- W4308373389 cites W2146885685 @default.
- W4308373389 cites W2147216559 @default.
- W4308373389 cites W2156469236 @default.
- W4308373389 cites W2169187688 @default.
- W4308373389 cites W2169403426 @default.
- W4308373389 cites W2182854135 @default.
- W4308373389 cites W2199551741 @default.
- W4308373389 cites W2442190208 @default.
- W4308373389 cites W2567793122 @default.
- W4308373389 cites W2594070229 @default.
- W4308373389 cites W2600060242 @default.
- W4308373389 cites W2753709051 @default.
- W4308373389 cites W2895857801 @default.
- W4308373389 cites W2896521168 @default.
- W4308373389 cites W2905124584 @default.
- W4308373389 cites W2905965925 @default.
- W4308373389 cites W2912658835 @default.
- W4308373389 cites W2949175413 @default.
- W4308373389 cites W2966419444 @default.
- W4308373389 cites W2968995517 @default.
- W4308373389 cites W2989278162 @default.
- W4308373389 cites W2992666626 @default.
- W4308373389 cites W2994268592 @default.
- W4308373389 cites W3016155570 @default.
- W4308373389 cites W3019973397 @default.
- W4308373389 cites W3023704375 @default.
- W4308373389 cites W3107573771 @default.
- W4308373389 cites W3136283854 @default.
- W4308373389 cites W3157598024 @default.
- W4308373389 cites W3201096757 @default.
- W4308373389 cites W4236982618 @default.
- W4308373389 cites W4282558982 @default.
- W4308373389 cites W4293247451 @default.
- W4308373389 cites W831921166 @default.
- W4308373389 doi "https://doi.org/10.1111/1744-7917.13130" @default.
- W4308373389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36342157" @default.
- W4308373389 hasPublicationYear "2022" @default.
- W4308373389 type Work @default.
- W4308373389 citedByCount "2" @default.
- W4308373389 countsByYear W43083733892023 @default.
- W4308373389 crossrefType "journal-article" @default.
- W4308373389 hasAuthorship W4308373389A5002391550 @default.
- W4308373389 hasAuthorship W4308373389A5004857519 @default.
- W4308373389 hasAuthorship W4308373389A5028995304 @default.
- W4308373389 hasAuthorship W4308373389A5038021915 @default.
- W4308373389 hasAuthorship W4308373389A5042916922 @default.
- W4308373389 hasAuthorship W4308373389A5058437368 @default.
- W4308373389 hasAuthorship W4308373389A5058780237 @default.
- W4308373389 hasAuthorship W4308373389A5059048284 @default.
- W4308373389 hasAuthorship W4308373389A5066135716 @default.
- W4308373389 hasAuthorship W4308373389A5086139839 @default.
- W4308373389 hasConcept C126322002 @default.
- W4308373389 hasConcept C134018914 @default.
- W4308373389 hasConcept C140985366 @default.
- W4308373389 hasConcept C141359234 @default.
- W4308373389 hasConcept C143937172 @default.
- W4308373389 hasConcept C171089720 @default.