Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308382417> ?p ?o ?g. }
- W4308382417 endingPage "106230" @default.
- W4308382417 startingPage "106230" @default.
- W4308382417 abstract "Colorectal cancer is a type of cancer encountered worldwide and ranks third among all cancer types in terms of incidence. Polyphenols have been shown to have a wide range of biological functions, including a significant impact on cancer start, development, and promotion through regulating many signaling pathways. The aim of this study was to investigate the anticancer effects of isoeugenol based compounds 1, 2 on HT29 colorectal cancer cell line in vitro. MTT test and scratch assay were carried out to determine the effect of these compounds on HT29 cell proliferation and migration respectively. In addition, mRNA expression levels of apoptosis and metastasis-related genes (p53, Bcl2, Bax, Caspase 3, Caspase7, Caspase8, Caspase9, HIF1-α, VEGF, MMP-2, MMP-9) were examined by quantitative real-time PCR. The results indicated that 1 and 2 inhibited HT29 cell proliferation and induced apoptosis by increasing the Bax/Bcl2 ratio and Caspase-9 and Caspase-3 mRNA expression. In conclusion, the results of this study showed that the treatment of these compounds significantly suppressed the mRNA expressions of metastasis-related genes such as Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, Vascular Endothelial Growth Factor and Hypoxia‑Inducible Factor 1α." @default.
- W4308382417 created "2022-11-11" @default.
- W4308382417 creator A5010749231 @default.
- W4308382417 creator A5027035357 @default.
- W4308382417 creator A5075153450 @default.
- W4308382417 creator A5087379954 @default.
- W4308382417 date "2023-01-01" @default.
- W4308382417 modified "2023-10-02" @default.
- W4308382417 title "Investigation of the effects of isoeugenol-based phenolic compounds on migration and proliferation of HT29 colon cancer cells at cellular and molecular level" @default.
- W4308382417 cites W1624747819 @default.
- W4308382417 cites W1870849870 @default.
- W4308382417 cites W1973090023 @default.
- W4308382417 cites W1986332208 @default.
- W4308382417 cites W1989890693 @default.
- W4308382417 cites W1991360752 @default.
- W4308382417 cites W1995068068 @default.
- W4308382417 cites W2011810742 @default.
- W4308382417 cites W2015466129 @default.
- W4308382417 cites W2025486904 @default.
- W4308382417 cites W2030103715 @default.
- W4308382417 cites W2034269086 @default.
- W4308382417 cites W2074305443 @default.
- W4308382417 cites W2084831115 @default.
- W4308382417 cites W2091671592 @default.
- W4308382417 cites W2094793438 @default.
- W4308382417 cites W2097656606 @default.
- W4308382417 cites W2100592123 @default.
- W4308382417 cites W2106582626 @default.
- W4308382417 cites W2112570485 @default.
- W4308382417 cites W2118330304 @default.
- W4308382417 cites W2130739077 @default.
- W4308382417 cites W2131400044 @default.
- W4308382417 cites W2135401734 @default.
- W4308382417 cites W2136607709 @default.
- W4308382417 cites W2158916045 @default.
- W4308382417 cites W2263405979 @default.
- W4308382417 cites W2527889170 @default.
- W4308382417 cites W2529267350 @default.
- W4308382417 cites W2553088533 @default.
- W4308382417 cites W2766927965 @default.
- W4308382417 cites W2783422906 @default.
- W4308382417 cites W2888459204 @default.
- W4308382417 cites W2910965847 @default.
- W4308382417 cites W2921003267 @default.
- W4308382417 cites W2972580999 @default.
- W4308382417 cites W2991287366 @default.
- W4308382417 cites W2991296497 @default.
- W4308382417 cites W3003385877 @default.
- W4308382417 cites W3009963727 @default.
- W4308382417 cites W3011481749 @default.
- W4308382417 cites W3088986342 @default.
- W4308382417 cites W3093238886 @default.
- W4308382417 cites W3095620416 @default.
- W4308382417 cites W3096845603 @default.
- W4308382417 cites W3112915907 @default.
- W4308382417 cites W3155343487 @default.
- W4308382417 cites W3158769140 @default.
- W4308382417 cites W3164163202 @default.
- W4308382417 cites W3182300858 @default.
- W4308382417 cites W90697117 @default.
- W4308382417 doi "https://doi.org/10.1016/j.bioorg.2022.106230" @default.
- W4308382417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36375352" @default.
- W4308382417 hasPublicationYear "2023" @default.
- W4308382417 type Work @default.
- W4308382417 citedByCount "2" @default.
- W4308382417 countsByYear W43083824172023 @default.
- W4308382417 crossrefType "journal-article" @default.
- W4308382417 hasAuthorship W4308382417A5010749231 @default.
- W4308382417 hasAuthorship W4308382417A5027035357 @default.
- W4308382417 hasAuthorship W4308382417A5075153450 @default.
- W4308382417 hasAuthorship W4308382417A5087379954 @default.
- W4308382417 hasConcept C109523444 @default.
- W4308382417 hasConcept C121608353 @default.
- W4308382417 hasConcept C153911025 @default.
- W4308382417 hasConcept C167734588 @default.
- W4308382417 hasConcept C178790620 @default.
- W4308382417 hasConcept C185592680 @default.
- W4308382417 hasConcept C190283241 @default.
- W4308382417 hasConcept C2777025900 @default.
- W4308382417 hasConcept C2779013556 @default.
- W4308382417 hasConcept C2780028989 @default.
- W4308382417 hasConcept C2780470866 @default.
- W4308382417 hasConcept C502942594 @default.
- W4308382417 hasConcept C526805850 @default.
- W4308382417 hasConcept C54355233 @default.
- W4308382417 hasConcept C55493867 @default.
- W4308382417 hasConcept C62112901 @default.
- W4308382417 hasConcept C86803240 @default.
- W4308382417 hasConcept C96232424 @default.
- W4308382417 hasConceptScore W4308382417C109523444 @default.
- W4308382417 hasConceptScore W4308382417C121608353 @default.
- W4308382417 hasConceptScore W4308382417C153911025 @default.
- W4308382417 hasConceptScore W4308382417C167734588 @default.
- W4308382417 hasConceptScore W4308382417C178790620 @default.
- W4308382417 hasConceptScore W4308382417C185592680 @default.
- W4308382417 hasConceptScore W4308382417C190283241 @default.
- W4308382417 hasConceptScore W4308382417C2777025900 @default.
- W4308382417 hasConceptScore W4308382417C2779013556 @default.