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- W4308383491 abstract "Previously, studies have demonstrated the unique characteristics of chitosan-gelatin films as wound dressings applications. However, their application has been limited due to their inadequacy of antimicrobial and anti-inflammatory characteristics. To improve the intended multifunctional characteristics of chitosan-gelatin film, in this study, we designed a novel composite film with the capability of controlled and prolonged release of thymol as a natural antioxidant and antimicrobial drug. Here, thymol-loaded ALG MPs (Thymol-ALG MPs) were prepared by electrospraying method and incorporated into the chitosan-gelatin film. The composite wound dressings of Thymol-ALG MPs incorporated in chitosan-gelatin film (CS-GEL/Thymol-ALG MPs) were characterized by in vitro and in vivo evaluations. The Thymol-ALG MPs demonstrated spherical and uniform morphology, with high encapsulation efficiency (88.9 ± 1.1 %). The CS-GEL/Thymol-ALG MPs exhibited high antibacterial activity against both Gram-positive and Gram-negative bacteria and no cytotoxicity for the L929 fibroblast cells. The release trend of thymol from CS-GEL/Thymol-ALG MPs and Thymol-ALG MPs followed a pseudo-Fickian diffusion mechanism. This wound dressing effectively accelerates the wound healing process at rats' full-thickness skin excisions. Also, the histological analysis demonstrated that the CS-GEL/Thymol-ALG MPs could significantly enhance epithelialization, collagen deposition, and induce skin regeneration. The present antibacterial composite film has promising characteristics for wound dressings applications." @default.
- W4308383491 created "2022-11-11" @default.
- W4308383491 creator A5047014439 @default.
- W4308383491 creator A5047121571 @default.
- W4308383491 creator A5047741401 @default.
- W4308383491 creator A5075399210 @default.
- W4308383491 date "2022-12-01" @default.
- W4308383491 modified "2023-10-04" @default.
- W4308383491 title "Fabrication of chitosan-gelatin films incorporated with thymol-loaded alginate microparticles for controlled drug delivery, antibacterial activity and wound healing: In-vitro and in-vivo studies" @default.
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- W4308383491 doi "https://doi.org/10.1016/j.ijbiomac.2022.10.249" @default.
- W4308383491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36356874" @default.
- W4308383491 hasPublicationYear "2022" @default.
- W4308383491 type Work @default.