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• W4308384998 endingPage "116822" @default.
• W4308384998 startingPage "116822" @default.
• W4308384998 abstract "A core challenge in biomedical and life science research is to decipher cell-to-cell differences under pathological progression or external perturbation. Microfluidics-based integrated systems serve as powerful tools for accurately investigating cellular phenotypes and molecular responses in the state of physiological and pathological processes at the single-cell scale. Here, we review the advanced microfluidic strategies for single-cell research relevant to tumorigenesis and evolution, immune responses, and drug discovery . The review will discuss the design of microfluidic devices for single-cell analysis, the current methods of microfluidic devices for single-cell isolation, and applications of microfluidics-based single-cell analysis in cell biology, disease diagnosis, and therapy. Specifically, we will focus on the microfluidics-based techniques for single-cell operation and recent strategies for single-cell measurements. Limitations and future perspectives of microfluidics-based single-cell analysis will also be discussed. • Growing fields of microfluidics-based strategies for single-cell research are reviewed. • Accurate microfabrication techniques are discussed in the design of microfluidic devices. • Integrated microfluidic techniques are presented in single-cell isolation and operation. • Perspectives in further development of microfluidics-based single-cell research are discussed." @default.
• W4308384998 created "2022-11-11" @default.
• W4308384998 creator A5021874293 @default.
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• W4308384998 creator A5060480074 @default.
• W4308384998 date "2022-12-01" @default.
• W4308384998 modified "2023-10-14" @default.
• W4308384998 title "Advances in microfluidic strategies for single-cell research" @default.
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