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• W4308385292 abstract "<h3>Background</h3> Even though immune checkpoint inhibitors have improved the survival of non-small cell lung cancer (NSCLC) patients, their prognosis is still poor. Natural Killer (NK) cells are lymphocytes with distinct anti-cancer properties, and NK cell activity (NKA) may have a prognostic role. Similarly, derived Neutrophils-to-lymphocyte ratio (dNLR) has been suggested as a prognostic biomarker in cancer patients. <h3>Methods</h3> Patients with advanced or recurrent NSCLC eligible for anti-PD-1/PD-L1 treatment were enrolled at the Department of Oncology, Vejle Hospital, Denmark. Blood was sampled at baseline and immediately before the following three cycles of therapy. Interferon gamma (IFNγ) as a surrogate for NKA was measured using the NK Vue^® assay (NKMAX, Seongnam-si, South Korea). Normal levels of IFNγ were considered as >250 pg/mL. Neutrophils and leukocytes were quantified by XN-9000 (Sysmex, Kobe, Japan). dNLR was calculated as (neutrophils/(leukocytes-neutrophils)) and dNLR<3 was considered normal. The study was approved by the Regional Committee on Health Research Ethics for Southern Denmark, approval number S-20170063. <h3>Results</h3> Baseline level of NKA had no prognostic impact for overall survival (OS) (p=0.1279, NKA-normal n=45 vs NKA-low n=27, logrank). Longitudinal sampling allowed us to determine if dynamics in NKA were of prognostic value. For this purpose, patients were grouped as follows: NKA-low group had NKA <250 pg/mL at all available time-points (n=13), NKA-mixed group had NKA of varying levels (n=34), and NKA-high group had NKA >250 pg/mL at all available time-points (n=29). A logrank test revealed a significant difference between the groups in terms of OS (p=0.0002). Compared to the NKA-high group, the NKA-low group had a poor prognosis with a hazard ratio (HR) of 3.690 (p=0.001). After adjusting for dNLR, histology and performance status it remained an independent prognostic factor (HR=3.581, p=0.005). Interestingly, while dNLR also had prognostic impact for overall survival (OS) (p=0.0274, dNLR<3 n=57 and dNLR>3 n=18, logrank) and dNLR>3 was a prognostic marker for poor OS in univariate analysis (HR=1.908, p=0.03), this was lost in multivariate analysis taking NKA, histology, and performance status into account (HR=1.364, p=0.451). <h3>Conclusions</h3> NKA dynamics, and not dNLR, was an independent prognostic marker for OS in NSCLC patients receiving anti-PD-1/PD-L1 treatment. These findings highlight the value of not restricting biomarker evaluation to immune cell enumeration, but rather looking at the ability of these cells to carry out vital immune functions. <h3>Ethics Approval</h3> The study was approved by the Regional Committee on Health Research Ethics for Southern Denmark, approval number S-20170063. All participants provided written informed consent." @default.
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• W4308385292 date "2022-11-01" @default.
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• W4308385292 title "1013 Prognostic value of natural killer cell activity and derived neutrophils-to-lymphocytes ratio in non-small cell lung cancer patients receiving immune checkpoint inhibitors" @default.
• W4308385292 doi "https://doi.org/10.1136/jitc-2022-sitc2022.1013" @default.
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