FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308387634> ?p ?o ?g. }

• W4308387634 endingPage "106219" @default.
• W4308387634 startingPage "106219" @default.
• W4308387634 abstract "Retinoid X receptors (RXRs) can form homo- or heterodimers with orphan receptors involved in multiple intertwined signaling pathways. However, there is limited study on the formation of sex phenotypes and the regulation of steroidogenesis by RXRs in fish. Here, in Paralichthys olivaceus, we first indicated that PPARγ::RXRα was predictably a transcription factor for steroidogenesis genes, and Foxl2 and Dmrt1 were also transcription factors for rxrs and their partner receptor genes. When the flounder fry were exposed to LG100268 (LG, RXRs agonist, 50 mg/kg diet), the percentage of males increased from 50% to 71.4%. Before histological differentiation of the flounder ovary (3 cm TL) and testis (6 cm TL), the transcripts of rar β and rar γ (P < 0.05) were activated, and the steroidogenesis gene Hsd3b1 was down-regulated (P < 0.05). The ratios of testosterone (T)/17β-estradiol (E2) were all greatly increased (P < 0.05), and the ratio of 11-ketotestosterone (11-KT)/E2 was elevated at 3 cm TL. Moreover, LG was used to treat the cultured gonads in vitro (10 μM) and the fish with intraperitoneal injection in vivo (12 mg/kg body weight), respectively. LG was able to up-regulate rxr γ, rar γ, and ppar δ, and Hsd3b1 was significantly up-regulated (P < 0.05). The ratios of 11-KT/E2 in the culture medium and in the ovaries of the fish were decreased. Furthermore, the recombinant flounder Foxl2 protein was able to significantly down-regulate ppar γ (P < 0.05) and tr β (P < 0.01) in the ovaries in vitro, and the result of the Dmrt1 in the testes was opposite to that of the Foxl2, probably indicating a feedback loop between RXRs' partner receptors and Foxl2/Dmrt1. These findings introduce for the first time the mode of action of RXRs on the flounder steroidogenesis and provide important data to learn the potential function of RXRs in fish sex differentiation and the potential role of RXRs in aquatic animals in the presence of water pollutants." @default.
• W4308387634 created "2022-11-11" @default.
• W4308387634 creator A5015439449 @default.
• W4308387634 creator A5027834336 @default.
• W4308387634 creator A5047841086 @default.
• W4308387634 creator A5060786274 @default.
• W4308387634 creator A5066222509 @default.
• W4308387634 creator A5066494257 @default.
• W4308387634 creator A5073435344 @default.
• W4308387634 creator A5078642611 @default.
• W4308387634 creator A5083384208 @default.
• W4308387634 creator A5091285322 @default.
• W4308387634 date "2023-02-01" @default.
• W4308387634 modified "2023-10-16" @default.
• W4308387634 title "Rxrs and their partner receptor genes inducing masculinization plausibly mediated by endocrine disruption in Paralichthys olivaceus" @default.
• W4308387634 cites W1544302179 @default.
• W4308387634 cites W1629512138 @default.
• W4308387634 cites W1995754186 @default.
• W4308387634 cites W1999669689 @default.
• W4308387634 cites W2007123568 @default.
• W4308387634 cites W2012320318 @default.
• W4308387634 cites W2016167989 @default.
• W4308387634 cites W2041668798 @default.
• W4308387634 cites W2059348089 @default.
• W4308387634 cites W2072822958 @default.
• W4308387634 cites W2072967941 @default.
• W4308387634 cites W2073067797 @default.
• W4308387634 cites W2085909854 @default.
• W4308387634 cites W2091655414 @default.
• W4308387634 cites W2091897891 @default.
• W4308387634 cites W2095229198 @default.
• W4308387634 cites W2140543218 @default.
• W4308387634 cites W2159288881 @default.
• W4308387634 cites W2175842617 @default.
• W4308387634 cites W2216590935 @default.
• W4308387634 cites W2512939707 @default.
• W4308387634 cites W2560662711 @default.
• W4308387634 cites W2615923439 @default.
• W4308387634 cites W2764155988 @default.
• W4308387634 cites W2902181701 @default.
• W4308387634 cites W2922057239 @default.
• W4308387634 cites W2936116838 @default.
• W4308387634 cites W2940676612 @default.
• W4308387634 cites W2945396835 @default.
• W4308387634 cites W2954222607 @default.
• W4308387634 cites W2955484248 @default.
• W4308387634 cites W2974573575 @default.
• W4308387634 cites W2980460706 @default.
• W4308387634 cites W2989840913 @default.
• W4308387634 cites W2990493200 @default.
• W4308387634 cites W2999571033 @default.
• W4308387634 cites W3015914767 @default.
• W4308387634 cites W3027842421 @default.
• W4308387634 cites W3034762717 @default.
• W4308387634 cites W3041301330 @default.
• W4308387634 cites W3081066272 @default.
• W4308387634 cites W3096442073 @default.
• W4308387634 cites W3116640948 @default.
• W4308387634 cites W3121199423 @default.
• W4308387634 cites W3122888916 @default.
• W4308387634 cites W3134932909 @default.
• W4308387634 cites W3136965070 @default.
• W4308387634 cites W3195408614 @default.
• W4308387634 cites W3203947739 @default.
• W4308387634 cites W3206394788 @default.
• W4308387634 cites W4206475549 @default.
• W4308387634 cites W4214510532 @default.
• W4308387634 cites W4280632829 @default.
• W4308387634 cites W4282966339 @default.
• W4308387634 cites W4296174840 @default.
• W4308387634 doi "https://doi.org/10.1016/j.jsbmb.2022.106219" @default.
• W4308387634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36356854" @default.
• W4308387634 hasPublicationYear "2023" @default.
• W4308387634 type Work @default.
• W4308387634 citedByCount "0" @default.
• W4308387634 crossrefType "journal-article" @default.
• W4308387634 hasAuthorship W4308387634A5015439449 @default.
• W4308387634 hasAuthorship W4308387634A5027834336 @default.
• W4308387634 hasAuthorship W4308387634A5047841086 @default.
• W4308387634 hasAuthorship W4308387634A5060786274 @default.
• W4308387634 hasAuthorship W4308387634A5066222509 @default.
• W4308387634 hasAuthorship W4308387634A5066494257 @default.
• W4308387634 hasAuthorship W4308387634A5073435344 @default.
• W4308387634 hasAuthorship W4308387634A5078642611 @default.
• W4308387634 hasAuthorship W4308387634A5083384208 @default.
• W4308387634 hasAuthorship W4308387634A5091285322 @default.
• W4308387634 hasConcept C104317684 @default.
• W4308387634 hasConcept C126322002 @default.
• W4308387634 hasConcept C128821507 @default.
• W4308387634 hasConcept C134018914 @default.
• W4308387634 hasConcept C170493617 @default.
• W4308387634 hasConcept C2775954498 @default.
• W4308387634 hasConcept C2776367567 @default.
• W4308387634 hasConcept C2776533291 @default.
• W4308387634 hasConcept C2781121885 @default.
• W4308387634 hasConcept C2909208804 @default.
• W4308387634 hasConcept C505870484 @default.
• W4308387634 hasConcept C54355233 @default.

• next