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• W4308387673 abstract "Numerous clinical studies have shown a wide clinical potential of mesenchymal stromal cells (MSCs) application. However, recent experience has accumulated numerous reports of adverse events and side effects associated with MSCs therapy. Furthermore, the strategies and methods of MSCs therapy did not change significantly in recent decades despite the clinical impact and awareness of potential complications. An extended understanding of limitations could lead to a wider clinical implementation of safe cell therapies and avoid harmful approaches. Therefore, our objective was to summarize the possible negative effects observed during MSCs-based therapies. We were also aimed to discuss the risks caused by weaknesses in cell processing, including isolation, culturing, and storage. Cell processing and cell culture could dramatically influence cell population profile, change protein expression and cell differentiation paving the way for future negative effects. Long-term cell culture led to accumulation of chromosomal abnormalities. Overdosed antibiotics in culture media enhanced the risk of mycoplasma contamination. Clinical trials reported thromboembolism and fibrosis as the most common adverse events of MSCs therapy. Their delayed manifestation generally depends on the patient's individual phenotype and requires specific awareness during the clinical trials with obligatory inclusion in the patient' informed consents. Finally we prepared the safety checklist, recommended for clinical specialists before administration or planning of MSCs therapy." @default.
• W4308387673 created "2022-11-11" @default.
• W4308387673 creator A5000527949 @default.
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• W4308387673 date "2022-11-01" @default.
• W4308387673 modified "2023-10-16" @default.
• W4308387673 title "Adverse events, side effects and complications in mesenchymal stromal cell-based therapies" @default.
• W4308387673 cites W1532616018 @default.
• W4308387673 cites W1572554967 @default.
• W4308387673 cites W1593699141 @default.
• W4308387673 cites W1935842376 @default.
• W4308387673 cites W1969421891 @default.
• W4308387673 cites W1970266024 @default.
• W4308387673 cites W1982313967 @default.
• W4308387673 cites W1983493560 @default.
• W4308387673 cites W1985367412 @default.
• W4308387673 cites W1993326869 @default.
• W4308387673 cites W2000161822 @default.
• W4308387673 cites W2002608402 @default.
• W4308387673 cites W2002620928 @default.
• W4308387673 cites W2004709232 @default.
• W4308387673 cites W2008899987 @default.
• W4308387673 cites W2021514058 @default.
• W4308387673 cites W2027034506 @default.
• W4308387673 cites W2030839210 @default.
• W4308387673 cites W2046828222 @default.
• W4308387673 cites W2051893135 @default.
• W4308387673 cites W2059880083 @default.
• W4308387673 cites W2060387475 @default.
• W4308387673 cites W2062664650 @default.
• W4308387673 cites W2066767028 @default.
• W4308387673 cites W2066954473 @default.
• W4308387673 cites W2075574520 @default.
• W4308387673 cites W2082030284 @default.
• W4308387673 cites W2082251601 @default.
• W4308387673 cites W2084849128 @default.
• W4308387673 cites W2085013061 @default.
• W4308387673 cites W2088340449 @default.
• W4308387673 cites W2094945699 @default.
• W4308387673 cites W2102330961 @default.
• W4308387673 cites W2116259052 @default.
• W4308387673 cites W2137891306 @default.
• W4308387673 cites W2141417144 @default.
• W4308387673 cites W2143758994 @default.
• W4308387673 cites W2153340619 @default.
• W4308387673 cites W2153914873 @default.
• W4308387673 cites W2159607456 @default.
• W4308387673 cites W2164829386 @default.
• W4308387673 cites W2207758069 @default.
• W4308387673 cites W2216893423 @default.
• W4308387673 cites W2253835652 @default.
• W4308387673 cites W2273064048 @default.
• W4308387673 cites W2312606546 @default.
• W4308387673 cites W2340568413 @default.
• W4308387673 cites W2528833623 @default.
• W4308387673 cites W2539567223 @default.
• W4308387673 cites W2554672040 @default.
• W4308387673 cites W2587925420 @default.
• W4308387673 cites W2588674441 @default.
• W4308387673 cites W2603718872 @default.
• W4308387673 cites W2605484523 @default.
• W4308387673 cites W2607420694 @default.
• W4308387673 cites W2619379016 @default.
• W4308387673 cites W2666404430 @default.
• W4308387673 cites W2734783958 @default.
• W4308387673 cites W2736212299 @default.
• W4308387673 cites W2737562130 @default.
• W4308387673 cites W2747456637 @default.
• W4308387673 cites W2749551577 @default.
• W4308387673 cites W2751308524 @default.
• W4308387673 cites W2758616494 @default.
• W4308387673 cites W2765490946 @default.
• W4308387673 cites W2790928579 @default.
• W4308387673 cites W2791064078 @default.
• W4308387673 cites W2791917443 @default.
• W4308387673 cites W2792667030 @default.
• W4308387673 cites W2901220228 @default.
• W4308387673 cites W2902115786 @default.
• W4308387673 cites W2913905282 @default.
• W4308387673 cites W2955673531 @default.
• W4308387673 cites W2958722283 @default.
• W4308387673 cites W2966412509 @default.
• W4308387673 cites W2988687407 @default.
• W4308387673 cites W2991252427 @default.
• W4308387673 cites W3011568661 @default.
• W4308387673 cites W3018259108 @default.
• W4308387673 cites W3024418121 @default.
• W4308387673 cites W3027754404 @default.
• W4308387673 cites W3039708318 @default.
• W4308387673 cites W3047907778 @default.
• W4308387673 cites W3080114020 @default.

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