FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308393151> ?p ?o ?g. }

• W4308393151 abstract "Abstract Background & Aims Liver cancer is one of the most leading causes of cancer deaths. Cirrhosis is an important risk factor for liver cancer, which is the result of over-fibrosis caused by diffuse and long-term liver damage. Despite extensive research, a systematic study for characterizing similarity between liver cancer and cirrhosis at single cell resolution is still lacking. Methods We established a data analysis framework to elucidate cell lineage similarity between liver cancer and cirrhosis to discover prognostic-associated subpopulations. We integrated single-cell transcriptome data from liver samples at normal, cirrhotic and cancer conditions, which totally contained 78,000 cells. Gene regulation analysis, cellular interactions and trajectory analysis were performed to characterize cirrhosis-like cell subpopulations. Bulk transcriptomes were used to discover prognostic-associated subpopulations. Results By aligning cellular subpopulations across different samples, we found remarkable similarity between KNG1 + hepatocytes in cirrhosis and PGA5 + hepatocytes in HCC. Furthermore, gene regulation analysis and cellular interactions implicated E2F1, FOXA2, EGF, CDH and ANGPTL signaling in maintaining cirrhosis-like ecosystem. Strikingly, subpopulations with higher expression of cirrhosis-like signatures were associated with patients’ worse survival. Conclusions We revealed a previously unexplored cirrhosis-like ecosystem of liver cancer, which could provide novel biomarkers for therapeutic interventions in HCC. Core analysis modules in this study were integrated into a user-friendly toolkit, SIM scRNA ( https://github.com/xmuhuanglab/SIM-scRNA ), which could facilitate the exploration of similarity and heterogeneity between precancerous diseases and solid tumors." @default.
• W4308393151 created "2022-11-11" @default.
• W4308393151 creator A5002483167 @default.
• W4308393151 creator A5006838316 @default.
• W4308393151 creator A5007662692 @default.
• W4308393151 creator A5016680184 @default.
• W4308393151 creator A5019762338 @default.
• W4308393151 creator A5044939327 @default.
• W4308393151 creator A5075139838 @default.
• W4308393151 creator A5076414326 @default.
• W4308393151 creator A5089862145 @default.
• W4308393151 date "2022-11-04" @default.
• W4308393151 modified "2023-10-14" @default.
• W4308393151 title "Integrated analysis of single-cell transcriptome of liver cancer and cirrhosis reveals cell lineage similarity and prognostic-associated subpopulations" @default.
• W4308393151 cites W115528016 @default.
• W4308393151 cites W1973027060 @default.
• W4308393151 cites W2021526338 @default.
• W4308393151 cites W2030017878 @default.
• W4308393151 cites W2046632580 @default.
• W4308393151 cites W2063406261 @default.
• W4308393151 cites W2070323020 @default.
• W4308393151 cites W2078197314 @default.
• W4308393151 cites W2088849513 @default.
• W4308393151 cites W2102948810 @default.
• W4308393151 cites W2121309812 @default.
• W4308393151 cites W2140291158 @default.
• W4308393151 cites W2159707944 @default.
• W4308393151 cites W2162219788 @default.
• W4308393151 cites W2162566260 @default.
• W4308393151 cites W2170989872 @default.
• W4308393151 cites W2179438025 @default.
• W4308393151 cites W2562967659 @default.
• W4308393151 cites W2616922646 @default.
• W4308393151 cites W2625559053 @default.
• W4308393151 cites W2660993003 @default.
• W4308393151 cites W2724543993 @default.
• W4308393151 cites W2768491523 @default.
• W4308393151 cites W2800392236 @default.
• W4308393151 cites W2898120081 @default.
• W4308393151 cites W2900879077 @default.
• W4308393151 cites W2925075625 @default.
• W4308393151 cites W2942354172 @default.
• W4308393151 cites W2942610007 @default.
• W4308393151 cites W2950372712 @default.
• W4308393151 cites W2952382623 @default.
• W4308393151 cites W2958554910 @default.
• W4308393151 cites W2974173533 @default.
• W4308393151 cites W2979595830 @default.
• W4308393151 cites W2992151131 @default.
• W4308393151 cites W2992433783 @default.
• W4308393151 cites W3004162760 @default.
• W4308393151 cites W3009880690 @default.
• W4308393151 cites W3016360824 @default.
• W4308393151 cites W3019441095 @default.
• W4308393151 cites W3022296412 @default.
• W4308393151 cites W3043538464 @default.
• W4308393151 cites W3082212681 @default.
• W4308393151 cites W3086206613 @default.
• W4308393151 cites W3087952073 @default.
• W4308393151 cites W3093039366 @default.
• W4308393151 cites W3093993838 @default.
• W4308393151 cites W3132661792 @default.
• W4308393151 cites W3164896986 @default.
• W4308393151 cites W3175283754 @default.
• W4308393151 cites W4200108980 @default.
• W4308393151 cites W4211025847 @default.
• W4308393151 cites W4211105405 @default.
• W4308393151 cites W4213241964 @default.
• W4308393151 cites W4220750490 @default.
• W4308393151 cites W4221120384 @default.
• W4308393151 cites W4224084840 @default.
• W4308393151 cites W4285730635 @default.
• W4308393151 cites W4286203178 @default.
• W4308393151 doi "https://doi.org/10.1101/2022.11.03.515124" @default.
• W4308393151 hasPublicationYear "2022" @default.
• W4308393151 type Work @default.
• W4308393151 citedByCount "0" @default.
• W4308393151 crossrefType "posted-content" @default.
• W4308393151 hasAuthorship W4308393151A5002483167 @default.
• W4308393151 hasAuthorship W4308393151A5006838316 @default.
• W4308393151 hasAuthorship W4308393151A5007662692 @default.
• W4308393151 hasAuthorship W4308393151A5016680184 @default.
• W4308393151 hasAuthorship W4308393151A5019762338 @default.
• W4308393151 hasAuthorship W4308393151A5044939327 @default.
• W4308393151 hasAuthorship W4308393151A5075139838 @default.
• W4308393151 hasAuthorship W4308393151A5076414326 @default.
• W4308393151 hasAuthorship W4308393151A5089862145 @default.
• W4308393151 hasBestOaLocation W43083931511 @default.
• W4308393151 hasConcept C104317684 @default.
• W4308393151 hasConcept C121608353 @default.
• W4308393151 hasConcept C126322002 @default.
• W4308393151 hasConcept C1491633281 @default.
• W4308393151 hasConcept C150194340 @default.
• W4308393151 hasConcept C162317418 @default.
• W4308393151 hasConcept C2776231280 @default.
• W4308393151 hasConcept C2777214474 @default.
• W4308393151 hasConcept C2778019345 @default.
• W4308393151 hasConcept C502942594 @default.
• W4308393151 hasConcept C54355233 @default.
• W4308393151 hasConcept C60644358 @default.

• next