FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308394518> ?p ?o ?g. }

• W4308394518 abstract "<h3>Background</h3> Expansion of therapeutic strategies against diffuse large B-cell lymphoma (DLBCL) offers new opportunities to fight aggressive non-Hodgkin’s lymphoma. To unveil mechanisms driving cancer evolution and tumor immune contexture from a personalized medicine and diagnostic assay perspective, we sought to build a first-in-class reference database. Using a high-quality testing and innovative multimodal and integrative approach, the first Veracyte Biopharma Atlas for DLBCL evaluated thousands of parameters across more than 150 pre-treatment DLBCL lesions and enabled us to precisely map the spectrum of tumor microenvironments across samples and to establish a robust unsupervised descriptive model. By projecting new specimens associated to relevant clinical information and sample data onto the referential map, Atlas analysis provides a detailed description of the tumor microenvironment and facilitates the development of predictive and prognostic tools. <h3>Methods</h3> Veracyte Biopharma Atlas characterizes the tumor microenvironment by analyzing information from 3 different modalities: (i) proteomics (Brightplex® panels), (ii) transcriptomics (RNA sequencing and hybridization using Nanostring technology), (iii) genomics (somatic mutations by exome sequencing and/or the rearrangement of the V(D)J regions of the CDR3 receptor of T cells). The specificity, complexity and volume of the information generated required the development of mathematical and bioinformatics processing to extract relevant biological information. The Veracyte Biopharma Atlas innovative approach combines linear (multimodal factor analysis) and non-linear (self-organizing map) approaches with graphical representation of the data. Finally, the incorporation of clinical annotation, either from samples used to generate the map or from clinical specimens projected onto the Atlas, made it possible to identify specific patterns predictive of a clinical parameter of interest (eg, response or toxicity). <h3>Results</h3> Gene expression profiling, genomic analysis and proteomics by multiplex spatial technology were performed on more than 150 DLBCL samples collected at diagnosis. Using a centralized multi-omics integrative approach, data were analyzed to capture DLBCL immune contexture. Multimodal analysis allowing multifactor integration was used to derive a unique Atlas map and identify key features. Baseline and screening samples from axicabtagene ciloleucel (axi-cel) anti-CD19 chimeric antigen receptor (CAR) T-cell treated patients from the pivotal ZUMA-1 trial were analyzed with the same multi-omics integrative approach. Projection of ZUMA-1 immune contexture data onto the Atlas map revealed actionable information related to patients receiving CAR-T-cell treatment. <h3>Conclusions</h3> Projection of CAR-T clinical trial data highlighted the Veracyte Biopharma Atlas as a powerful tool to stratify patients and identify key immune biomarkers linked to response to CAR T-cell therapy. <h3>Ethics Approval</h3> The study protocol for the single-arm, multicenter, registrational ZUMA-1 study of axi-cel in patients with relapsed LBCL was previously described.^{1 2} Each study site’s institutional review board reviewed and approved the study protocol and amendments, and all patients provided written informed consent. The study was done according to the International Conference on Harmonisation Good Clinical Practice guidelines. Patients in the ZUMA-1 study did not receive compensation for their participation in the study. <h3>References</h3> Jensen MC, Riddell SR. Design and implementation of adoptive therapy with chimeric antigen receptor-modified T-cells. <i>Immunological Reviews</i> 2014;<b>257</b>:127-144. Yang JC, Rosenberg SA. Adoptive T-cell therapy for cancer. <i>Adv Immunol</i> 2016;<b>130</b>:279-294." @default.
• W4308394518 created "2022-11-11" @default.
• W4308394518 creator A5020001580 @default.
• W4308394518 creator A5021218555 @default.
• W4308394518 creator A5021394406 @default.
• W4308394518 creator A5025066483 @default.
• W4308394518 creator A5037111172 @default.
• W4308394518 creator A5037526878 @default.
• W4308394518 creator A5061181051 @default.
• W4308394518 creator A5061482931 @default.
• W4308394518 creator A5064752432 @default.
• W4308394518 creator A5069450479 @default.
• W4308394518 creator A5070615133 @default.
• W4308394518 creator A5077959781 @default.
• W4308394518 creator A5081926380 @default.
• W4308394518 creator A5085514831 @default.
• W4308394518 creator A5088232703 @default.
• W4308394518 creator A5090060276 @default.
• W4308394518 creator A5090694142 @default.
• W4308394518 date "2022-11-01" @default.
• W4308394518 modified "2023-10-03" @default.
• W4308394518 title "1454 Multiomics and multimodal analysis approach to construct a diffuse large B cell lymphoma atlas of tumor microenvironment for predictive modeling" @default.
• W4308394518 doi "https://doi.org/10.1136/jitc-2022-sitc2022.1454" @default.
• W4308394518 hasPublicationYear "2022" @default.
• W4308394518 type Work @default.
• W4308394518 citedByCount "0" @default.
• W4308394518 crossrefType "proceedings-article" @default.
• W4308394518 hasAuthorship W4308394518A5020001580 @default.
• W4308394518 hasAuthorship W4308394518A5021218555 @default.
• W4308394518 hasAuthorship W4308394518A5021394406 @default.
• W4308394518 hasAuthorship W4308394518A5025066483 @default.
• W4308394518 hasAuthorship W4308394518A5037111172 @default.
• W4308394518 hasAuthorship W4308394518A5037526878 @default.
• W4308394518 hasAuthorship W4308394518A5061181051 @default.
• W4308394518 hasAuthorship W4308394518A5061482931 @default.
• W4308394518 hasAuthorship W4308394518A5064752432 @default.
• W4308394518 hasAuthorship W4308394518A5069450479 @default.
• W4308394518 hasAuthorship W4308394518A5070615133 @default.
• W4308394518 hasAuthorship W4308394518A5077959781 @default.
• W4308394518 hasAuthorship W4308394518A5081926380 @default.
• W4308394518 hasAuthorship W4308394518A5085514831 @default.
• W4308394518 hasAuthorship W4308394518A5088232703 @default.
• W4308394518 hasAuthorship W4308394518A5090060276 @default.
• W4308394518 hasAuthorship W4308394518A5090694142 @default.
• W4308394518 hasBestOaLocation W43083945181 @default.
• W4308394518 hasConcept C142724271 @default.
• W4308394518 hasConcept C151730666 @default.
• W4308394518 hasConcept C2776107976 @default.
• W4308394518 hasConcept C2776673561 @default.
• W4308394518 hasConcept C2778559949 @default.
• W4308394518 hasConcept C2779338263 @default.
• W4308394518 hasConcept C3020616263 @default.
• W4308394518 hasConcept C41008148 @default.
• W4308394518 hasConcept C502942594 @default.
• W4308394518 hasConcept C70721500 @default.
• W4308394518 hasConcept C71924100 @default.
• W4308394518 hasConcept C86803240 @default.
• W4308394518 hasConceptScore W4308394518C142724271 @default.
• W4308394518 hasConceptScore W4308394518C151730666 @default.
• W4308394518 hasConceptScore W4308394518C2776107976 @default.
• W4308394518 hasConceptScore W4308394518C2776673561 @default.
• W4308394518 hasConceptScore W4308394518C2778559949 @default.
• W4308394518 hasConceptScore W4308394518C2779338263 @default.
• W4308394518 hasConceptScore W4308394518C3020616263 @default.
• W4308394518 hasConceptScore W4308394518C41008148 @default.
• W4308394518 hasConceptScore W4308394518C502942594 @default.
• W4308394518 hasConceptScore W4308394518C70721500 @default.
• W4308394518 hasConceptScore W4308394518C71924100 @default.
• W4308394518 hasConceptScore W4308394518C86803240 @default.
• W4308394518 hasLocation W43083945181 @default.
• W4308394518 hasOpenAccess W4308394518 @default.
• W4308394518 hasPrimaryLocation W43083945181 @default.
• W4308394518 hasRelatedWork W2900252041 @default.
• W4308394518 hasRelatedWork W2983460157 @default.
• W4308394518 hasRelatedWork W2991813790 @default.
• W4308394518 hasRelatedWork W3041576950 @default.
• W4308394518 hasRelatedWork W3128501672 @default.
• W4308394518 hasRelatedWork W3134966331 @default.
• W4308394518 hasRelatedWork W3167499897 @default.
• W4308394518 hasRelatedWork W3217192868 @default.
• W4308394518 hasRelatedWork W4362546471 @default.
• W4308394518 hasRelatedWork W4362558858 @default.
• W4308394518 isParatext "false" @default.
• W4308394518 isRetracted "false" @default.
• W4308394518 workType "article" @default.