Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308403711> ?p ?o ?g. }
- W4308403711 endingPage "134509" @default.
- W4308403711 startingPage "134509" @default.
- W4308403711 abstract "Studying DNA interaction with different drugs is interesting and important in discovering the interaction mechanism and developing novel drugs. Mitoxantrone (MTX) is a potent antitumor drug used to treat certain types of cancer. In this work, we evaluated the binding strength of MTX to 16 base pair double strands (ds) DNA. For the first time, this work investigates the intercalation of anticancer drugs into DNA by spectral fluorescence spectroscopy and SPR (surface plasmon resonance) based methods. Furthermore, the thermodynamic and kinetic parameters, including KD, KA, entropy change (ΔS), enthalpy change (ΔH), and ΔG, were calculated using different concentrations of ds DNA at three different temperatures. The results indicated that MTX binding to DNA was an exothermic and spontaneous process. The negative value of both ΔH and ΔS calculated by SPR and fluorescence data analysis showed that hydrogen bonding was the major binding force for the complexation of MTX to DNA. In addition, fluorescence data analysis revealed that MTX could quench the DNA fluorescence via the static quenching mechanism. This study shows that the investigation of intercalation anticancer drugs into DNA can be studied by spectral methods and can be investigated using SPR based method, and obtained data from the SPR method is as reliable as the fluorescence method. The present work shows hydrogen bonding is the major binding force in intercalating MTX to DNA." @default.
- W4308403711 created "2022-11-11" @default.
- W4308403711 creator A5009584560 @default.
- W4308403711 creator A5035288873 @default.
- W4308403711 creator A5036503576 @default.
- W4308403711 creator A5071362707 @default.
- W4308403711 creator A5074094786 @default.
- W4308403711 date "2023-02-01" @default.
- W4308403711 modified "2023-10-10" @default.
- W4308403711 title "Intercalation of anticancer drug mitoxantrone into DNA: Studied by spectral and surface plasmon resonance methods" @default.
- W4308403711 cites W1969986879 @default.
- W4308403711 cites W1988069691 @default.
- W4308403711 cites W1988685745 @default.
- W4308403711 cites W1990660233 @default.
- W4308403711 cites W1998723973 @default.
- W4308403711 cites W2026200299 @default.
- W4308403711 cites W2027013948 @default.
- W4308403711 cites W2027310997 @default.
- W4308403711 cites W2050012590 @default.
- W4308403711 cites W2050634094 @default.
- W4308403711 cites W2056202346 @default.
- W4308403711 cites W2067878166 @default.
- W4308403711 cites W2109535059 @default.
- W4308403711 cites W2158235576 @default.
- W4308403711 cites W2270796408 @default.
- W4308403711 cites W2313912827 @default.
- W4308403711 cites W2500915768 @default.
- W4308403711 cites W2754529833 @default.
- W4308403711 cites W2785296761 @default.
- W4308403711 cites W2792413654 @default.
- W4308403711 cites W2923220964 @default.
- W4308403711 cites W2942613831 @default.
- W4308403711 cites W2953251482 @default.
- W4308403711 cites W2979878037 @default.
- W4308403711 cites W2986636006 @default.
- W4308403711 cites W3025134788 @default.
- W4308403711 cites W3029220670 @default.
- W4308403711 cites W3030723095 @default.
- W4308403711 cites W3047488896 @default.
- W4308403711 cites W3049080228 @default.
- W4308403711 cites W3135321413 @default.
- W4308403711 cites W3159237374 @default.
- W4308403711 cites W3199284579 @default.
- W4308403711 cites W3204590125 @default.
- W4308403711 cites W4214939235 @default.
- W4308403711 cites W4220767515 @default.
- W4308403711 cites W4220828732 @default.
- W4308403711 cites W4220889561 @default.
- W4308403711 doi "https://doi.org/10.1016/j.molstruc.2022.134509" @default.
- W4308403711 hasPublicationYear "2023" @default.
- W4308403711 type Work @default.
- W4308403711 citedByCount "3" @default.
- W4308403711 countsByYear W43084037112023 @default.
- W4308403711 crossrefType "journal-article" @default.
- W4308403711 hasAuthorship W4308403711A5009584560 @default.
- W4308403711 hasAuthorship W4308403711A5035288873 @default.
- W4308403711 hasAuthorship W4308403711A5036503576 @default.
- W4308403711 hasAuthorship W4308403711A5071362707 @default.
- W4308403711 hasAuthorship W4308403711A5074094786 @default.
- W4308403711 hasConcept C106847996 @default.
- W4308403711 hasConcept C112887158 @default.
- W4308403711 hasConcept C113196181 @default.
- W4308403711 hasConcept C121332964 @default.
- W4308403711 hasConcept C137824038 @default.
- W4308403711 hasConcept C155672457 @default.
- W4308403711 hasConcept C171250308 @default.
- W4308403711 hasConcept C178790620 @default.
- W4308403711 hasConcept C185581394 @default.
- W4308403711 hasConcept C185592680 @default.
- W4308403711 hasConcept C192562407 @default.
- W4308403711 hasConcept C32909587 @default.
- W4308403711 hasConcept C43617362 @default.
- W4308403711 hasConcept C552990157 @default.
- W4308403711 hasConcept C55493867 @default.
- W4308403711 hasConcept C62520636 @default.
- W4308403711 hasConcept C91881484 @default.
- W4308403711 hasConceptScore W4308403711C106847996 @default.
- W4308403711 hasConceptScore W4308403711C112887158 @default.
- W4308403711 hasConceptScore W4308403711C113196181 @default.
- W4308403711 hasConceptScore W4308403711C121332964 @default.
- W4308403711 hasConceptScore W4308403711C137824038 @default.
- W4308403711 hasConceptScore W4308403711C155672457 @default.
- W4308403711 hasConceptScore W4308403711C171250308 @default.
- W4308403711 hasConceptScore W4308403711C178790620 @default.
- W4308403711 hasConceptScore W4308403711C185581394 @default.
- W4308403711 hasConceptScore W4308403711C185592680 @default.
- W4308403711 hasConceptScore W4308403711C192562407 @default.
- W4308403711 hasConceptScore W4308403711C32909587 @default.
- W4308403711 hasConceptScore W4308403711C43617362 @default.
- W4308403711 hasConceptScore W4308403711C552990157 @default.
- W4308403711 hasConceptScore W4308403711C55493867 @default.
- W4308403711 hasConceptScore W4308403711C62520636 @default.
- W4308403711 hasConceptScore W4308403711C91881484 @default.
- W4308403711 hasFunder F4320324013 @default.
- W4308403711 hasLocation W43084037111 @default.
- W4308403711 hasOpenAccess W4308403711 @default.
- W4308403711 hasPrimaryLocation W43084037111 @default.
- W4308403711 hasRelatedWork W1824074339 @default.