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• W4308405426 abstract "Abstract Variability in neurodegenerative disease progression poses great challenges for the evaluation of potential treatments. Identifying the persons who will experience significant progression in the short term is key for the implementation of trials with smaller sample sizes. We apply here disease course mapping to forecast biomarker progression for individual carriers of the pathological CAG repeat expansions responsible for Huntington disease. We used data from two longitudinal studies (TRACK-HD and TRACK-ON) to synchronize temporal progression of 15 clinical and imaging biomarkers from 290 participants with Huntington disease. We used then the resulting HD COURSE MAP to forecast clinical endpoints from the baseline data of 11,510 participants from ENROLL-HD, an external validation cohort. We used such forecasts to select participants at risk for progression and compute the power of trials for such an enriched population. HD COURSE MAP forecasts biomarkers 5 years after the baseline measures with a maximum mean absolute error of 10 points for the total motor score and 2.15 for the total functional capacity. This allowed reducing sample sizes in trial up to 50% including participants with a higher risk for progression ensuring a more homogeneous group of participants." @default.
• W4308405426 created "2022-11-11" @default.
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• W4308405426 date "2022-11-07" @default.
• W4308405426 modified "2023-10-18" @default.
• W4308405426 title "Forecasting individual progression trajectories in Huntington disease enables more powered clinical trials" @default.
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• W4308405426 doi "https://doi.org/10.1038/s41598-022-18848-8" @default.
• W4308405426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36344508" @default.
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