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• W4308406559 abstract "Abstract Background Within 24 hours a day, people are mostly in a non-fasting state. However, little is known about the characteristics and clinical significance of non-fasting lipids in Chinese population with coronary heart disease (CHD) in response to traditional Chinses diets. Methods A total number of 1022 Chinese CHD patients with coronary artery luminal stenosis more than 40% diagnosed by coronary artery angiography were enrolled. All the patients received the routine treatment for CHD, including statins. They were divided into intermediate stenosis group (luminal stenosis 40–70%, n = 486) or severe stenosis group (luminal stenosis > 70%, n = 536). Their blood lipid profiles were measured in the fasting state or 4 hours after normal breakfast. All the participants followed up for five years. Major adverse cardiovascular events (MACE) including all cause death, cardiac death, myocardial infarction, unscheduled coronary revascularization and stroke were recorded. Results After normal breakfast intake, patients with either intermediate or severe stenosis had an apparent increase from the fasting state in the levels of TG, remnant cholesterol (RC) and ApoA1, but a significant reduction in the levels of total cholesterol (TC), LDL-C, non-HDL-C, Apo B and Apo E. Multivariate logistic regression models showed that both the fasting and non-fasting levels of HDL-C and Apo A1 was negatively associated with the severity of coronary artery stenosis. In addition to the traditional risk factors (age, male, diabetes and smoking) and the severity of coronary artery stenosis, both the fasting and non-fasting levels of lipoproteins (LDL-C and HDL-C) and apolipoproteins (Apo A1 and Apo B) were identified as independent predictors of 5-year MACE occurrence by multivariate Cox proportional hazards analysis. Conclusion This prospective observational study demonstrated that the levels of lipoproteins and apolipoproteins in either fasting or non-fasting state were highly associated with the long-term risk of MACE in Chinses CHD patients. Measurements of lipid profiles in the non-fasting state may be feasible for CHD management in routine clinical practice in China." @default.
• W4308406559 created "2022-11-11" @default.
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• W4308406559 date "2022-11-07" @default.
• W4308406559 modified "2023-09-23" @default.
• W4308406559 title "Fasting and non-fasting lipoproteins and apolipoproteins for long-term outcome prediction in Chinese patients with coronary heart disease：a prospective observational study" @default.
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• W4308406559 doi "https://doi.org/10.21203/rs.3.rs-2218224/v1" @default.
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