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- W4308409824 abstract "The objective of this study was to develop ritonavir (RTV) nanosuspensions (NSs) by microfluidization method. Particle size (PS) measurements were performed by photon correlation spectroscopy. Amorphous properties of the particles were evaluated by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The dissolution studies were conducted in fed state simulated intestinal fluid (FeSSIF) medium. The flow cytometry was utilized to determine the lymphocyte sub-groups and immune response of NSs. RTV NSs were obtained with 400–500 nm PS. The crystal properties of RTV remain unchanged. The solubility of NS was enhanced five times. 57% and 18% of RTV were dissolved in FeSSIF medium for NSs and coarse powder. According to immunological studies, the prepared NSs did not significantly alter the ratio of CD4+/CD8+. Therefore, NSs may be a beneficial approach for the oral administration of RTV." @default.
- W4308409824 created "2022-11-11" @default.
- W4308409824 creator A5071406385 @default.
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- W4308409824 date "2022-11-14" @default.
- W4308409824 modified "2023-09-28" @default.
- W4308409824 title "Ritonavir nanosuspensions prepared by microfluidization with enhanced solubility and desirable immunological properties" @default.
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- W4308409824 doi "https://doi.org/10.1080/10837450.2022.2145309" @default.
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