FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308409901> ?p ?o ?g. }

• W4308409901 abstract "Abstract Natural Killer (NK) cells likely play an important role in immunity to malaria, but whether repeated malaria modifies the NK cell response remains unclear. Here, we comprehensively profiled the NK cell response in a cohort of 264 Ugandan children. Repeated malaria exposure was associated with expansion of an atypical, CD56neg population of NK cells that differed transcriptionally, epigenetically, and phenotypically from CD56dim NK cells, including decreased expression of PLZF and the Fc receptor g chain, increased histone methylation, and increased protein expression of LAG-3, KIR and LILRB1. CD56neg NK cells were highly functional, displaying greater antibody dependent cellular cytotoxicity than CD56dim NK cells, and higher frequencies of these cells were associated with protection against symptomatic malaria and high parasite densities. Importantly, following marked reductions in malaria transmission, frequencies of these cells rapidly declined, suggesting that continuous exposure to malaria is required to maintain this modified, adaptive-like NK cell subset." @default.
• W4308409901 created "2022-11-11" @default.
• W4308409901 creator A5010973711 @default.
• W4308409901 creator A5016358695 @default.
• W4308409901 creator A5020467733 @default.
• W4308409901 creator A5026667682 @default.
• W4308409901 creator A5029682053 @default.
• W4308409901 creator A5031492297 @default.
• W4308409901 creator A5033124739 @default.
• W4308409901 creator A5033791402 @default.
• W4308409901 creator A5033897984 @default.
• W4308409901 creator A5036212755 @default.
• W4308409901 creator A5042257703 @default.
• W4308409901 creator A5046059142 @default.
• W4308409901 creator A5047059123 @default.
• W4308409901 creator A5049534850 @default.
• W4308409901 creator A5053279355 @default.
• W4308409901 creator A5053491673 @default.
• W4308409901 creator A5054207126 @default.
• W4308409901 creator A5058402194 @default.
• W4308409901 creator A5059133928 @default.
• W4308409901 creator A5064818425 @default.
• W4308409901 creator A5064975456 @default.
• W4308409901 creator A5068243893 @default.
• W4308409901 creator A5074805970 @default.
• W4308409901 creator A5076202575 @default.
• W4308409901 creator A5080080229 @default.
• W4308409901 creator A5082906725 @default.
• W4308409901 creator A5083763463 @default.
• W4308409901 creator A5083823135 @default.
• W4308409901 creator A5085886829 @default.
• W4308409901 creator A5086773410 @default.
• W4308409901 date "2022-11-07" @default.
• W4308409901 modified "2023-09-27" @default.
• W4308409901 title "Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria" @default.
• W4308409901 doi "https://doi.org/10.21203/rs.3.rs-1820334/v1" @default.
• W4308409901 hasPublicationYear "2022" @default.
• W4308409901 type Work @default.
• W4308409901 citedByCount "1" @default.
• W4308409901 countsByYear W43084099012022 @default.
• W4308409901 crossrefType "posted-content" @default.
• W4308409901 hasAuthorship W4308409901A5010973711 @default.
• W4308409901 hasAuthorship W4308409901A5016358695 @default.
• W4308409901 hasAuthorship W4308409901A5020467733 @default.
• W4308409901 hasAuthorship W4308409901A5026667682 @default.
• W4308409901 hasAuthorship W4308409901A5029682053 @default.
• W4308409901 hasAuthorship W4308409901A5031492297 @default.
• W4308409901 hasAuthorship W4308409901A5033124739 @default.
• W4308409901 hasAuthorship W4308409901A5033791402 @default.
• W4308409901 hasAuthorship W4308409901A5033897984 @default.
• W4308409901 hasAuthorship W4308409901A5036212755 @default.
• W4308409901 hasAuthorship W4308409901A5042257703 @default.
• W4308409901 hasAuthorship W4308409901A5046059142 @default.
• W4308409901 hasAuthorship W4308409901A5047059123 @default.
• W4308409901 hasAuthorship W4308409901A5049534850 @default.
• W4308409901 hasAuthorship W4308409901A5053279355 @default.
• W4308409901 hasAuthorship W4308409901A5053491673 @default.
• W4308409901 hasAuthorship W4308409901A5054207126 @default.
• W4308409901 hasAuthorship W4308409901A5058402194 @default.
• W4308409901 hasAuthorship W4308409901A5059133928 @default.
• W4308409901 hasAuthorship W4308409901A5064818425 @default.
• W4308409901 hasAuthorship W4308409901A5064975456 @default.
• W4308409901 hasAuthorship W4308409901A5068243893 @default.
• W4308409901 hasAuthorship W4308409901A5074805970 @default.
• W4308409901 hasAuthorship W4308409901A5076202575 @default.
• W4308409901 hasAuthorship W4308409901A5080080229 @default.
• W4308409901 hasAuthorship W4308409901A5082906725 @default.
• W4308409901 hasAuthorship W4308409901A5083763463 @default.
• W4308409901 hasAuthorship W4308409901A5083823135 @default.
• W4308409901 hasAuthorship W4308409901A5085886829 @default.
• W4308409901 hasAuthorship W4308409901A5086773410 @default.
• W4308409901 hasBestOaLocation W43084099011 @default.
• W4308409901 hasConcept C159654299 @default.
• W4308409901 hasConcept C193419808 @default.
• W4308409901 hasConcept C203014093 @default.
• W4308409901 hasConcept C2778048844 @default.
• W4308409901 hasConcept C2779341262 @default.
• W4308409901 hasConcept C2908647359 @default.
• W4308409901 hasConcept C71924100 @default.
• W4308409901 hasConcept C86803240 @default.
• W4308409901 hasConcept C8891405 @default.
• W4308409901 hasConcept C99454951 @default.
• W4308409901 hasConceptScore W4308409901C159654299 @default.
• W4308409901 hasConceptScore W4308409901C193419808 @default.
• W4308409901 hasConceptScore W4308409901C203014093 @default.
• W4308409901 hasConceptScore W4308409901C2778048844 @default.
• W4308409901 hasConceptScore W4308409901C2779341262 @default.
• W4308409901 hasConceptScore W4308409901C2908647359 @default.
• W4308409901 hasConceptScore W4308409901C71924100 @default.
• W4308409901 hasConceptScore W4308409901C86803240 @default.
• W4308409901 hasConceptScore W4308409901C8891405 @default.
• W4308409901 hasConceptScore W4308409901C99454951 @default.
• W4308409901 hasLocation W43084099011 @default.
• W4308409901 hasOpenAccess W4308409901 @default.
• W4308409901 hasPrimaryLocation W43084099011 @default.
• W4308409901 hasRelatedWork W1901555156 @default.
• W4308409901 hasRelatedWork W2001695857 @default.
• W4308409901 hasRelatedWork W2037826520 @default.
• W4308409901 hasRelatedWork W2165065921 @default.
• W4308409901 hasRelatedWork W2228521159 @default.

• next