FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308417222> ?p ?o ?g. }

• W4308417222 abstract "Objectives To evaluate the predictive clinical role of neurofilament light chain (NfL), amyloid-β (Aβ), glial fibrillary acidic protein (GFAP), and phosphorylated tau at threonine 181 (p-tau181) proteins in human aqueous humor (AH) and quantify the retinal macular microvascular parameters by optical coherence tomography angiography (OCTA) as early diagnostic markers of Alzheimer’s disease (AD). Methods This prospective, single-site, cross-sectional, cohort study enrolled 55 participants, including 38 patients with neovascular age-related macular degeneration (nAMD) and 17 individuals with senile cataracts. The single-molecule array platform was used to quantitatively measure the levels of AH NfL, Aβ40, Aβ42, GFAP, and p-tau181 proteins in AH. The mini-mental state examination (MMSE) score was used to assess the global cognitive function. OCTA scan with 6 × 6 mm macular area was used to quantify the retinal thickness and microvascular densities of superficial retinal capillary plexuses and deep retinal capillary plexuses. Results NfL, Aβ40, Aβ42, GFAP, and p-tau181 were detected in all AH samples by Simoa platform. Individuals with cataract had higher concentrations of NfL and p-tau181 but lower Aβ40 and Aβ42 and similar GFAP compared to those with nAMD. Lower MMSE scores showed a negative correlation with NfL concentration of AH not only in the nAMD group ( p = 0.043), but also in the cataract group ( p = 0.032). However, the MMSE scores were not associated with the levels of Aβ40, Aβ42, GFAP, or p-Tau181. Further analysis found that the Aβ40 and Aβ42 concentrations showed a strong positive correlation ( p &lt; 0.0001). In addition, the NfL concentration showed a mild positive correlation with that of GFAP in the cataract group ( p = 0.021). Although it has not reached statistical significance, there was a correlation between the levels of NfL and Aβ42 in the nAMD group ( p = 0.051). Moreover, the macular superficial vessel density values had a negative correlation with the concentration of NfL ( p = 0.004) but a positive correlation with MMSE scores ( p = 0.045). The macular deep vessel density values were negatively correlated with the concentration of p-tau181 ( p = 0.031) and positively correlated with MMSE scores ( p = 0.020). Conclusion The examination of AD-related biomarkers in human AH and OCTA may improve the ocular-based AD detection methods and contribute to forestalling the progression of preclinical AD." @default.
• W4308417222 created "2022-11-11" @default.
• W4308417222 creator A5002188808 @default.
• W4308417222 creator A5004372635 @default.
• W4308417222 creator A5030107320 @default.
• W4308417222 creator A5053452393 @default.
• W4308417222 creator A5060963546 @default.
• W4308417222 creator A5062542913 @default.
• W4308417222 creator A5062642226 @default.
• W4308417222 creator A5071404986 @default.
• W4308417222 creator A5075515056 @default.
• W4308417222 date "2022-11-03" @default.
• W4308417222 modified "2023-10-01" @default.
• W4308417222 title "Association of cognitive function with Neurofilament light chain in the aqueous humor of human eye" @default.
• W4308417222 cites W1516093328 @default.
• W4308417222 cites W1566859968 @default.
• W4308417222 cites W1713296633 @default.
• W4308417222 cites W1927354065 @default.
• W4308417222 cites W1945356834 @default.
• W4308417222 cites W1975040154 @default.
• W4308417222 cites W1980850878 @default.
• W4308417222 cites W1991934654 @default.
• W4308417222 cites W1997526132 @default.
• W4308417222 cites W2025313923 @default.
• W4308417222 cites W2029817647 @default.
• W4308417222 cites W2045987400 @default.
• W4308417222 cites W2047572724 @default.
• W4308417222 cites W2068042309 @default.
• W4308417222 cites W2076286910 @default.
• W4308417222 cites W2077351936 @default.
• W4308417222 cites W2089055475 @default.
• W4308417222 cites W2090055826 @default.
• W4308417222 cites W2093134640 @default.
• W4308417222 cites W2142589181 @default.
• W4308417222 cites W2322058873 @default.
• W4308417222 cites W2327547544 @default.
• W4308417222 cites W2338815822 @default.
• W4308417222 cites W2338896782 @default.
• W4308417222 cites W2342233016 @default.
• W4308417222 cites W2551111288 @default.
• W4308417222 cites W2553114530 @default.
• W4308417222 cites W2577723374 @default.
• W4308417222 cites W2600002013 @default.
• W4308417222 cites W2600914407 @default.
• W4308417222 cites W2612128470 @default.
• W4308417222 cites W2621971267 @default.
• W4308417222 cites W2773245026 @default.
• W4308417222 cites W2782731988 @default.
• W4308417222 cites W2789046857 @default.
• W4308417222 cites W2809760236 @default.
• W4308417222 cites W2884982789 @default.
• W4308417222 cites W2886450553 @default.
• W4308417222 cites W2887484873 @default.
• W4308417222 cites W2888559826 @default.
• W4308417222 cites W2889006650 @default.
• W4308417222 cites W2902468475 @default.
• W4308417222 cites W2934745788 @default.
• W4308417222 cites W2939789416 @default.
• W4308417222 cites W2947686928 @default.
• W4308417222 cites W2967433988 @default.
• W4308417222 cites W2971269986 @default.
• W4308417222 cites W2972368830 @default.
• W4308417222 cites W3009441391 @default.
• W4308417222 cites W3087460625 @default.
• W4308417222 cites W3090170642 @default.
• W4308417222 cites W3132672365 @default.
• W4308417222 cites W3147383775 @default.
• W4308417222 cites W3154777360 @default.
• W4308417222 cites W3199484775 @default.
• W4308417222 cites W4220825176 @default.
• W4308417222 cites W4224436908 @default.
• W4308417222 doi "https://doi.org/10.3389/fnagi.2022.1027705" @default.
• W4308417222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36408096" @default.
• W4308417222 hasPublicationYear "2022" @default.
• W4308417222 type Work @default.
• W4308417222 citedByCount "1" @default.
• W4308417222 countsByYear W43084172222023 @default.
• W4308417222 crossrefType "journal-article" @default.
• W4308417222 hasAuthorship W4308417222A5002188808 @default.
• W4308417222 hasAuthorship W4308417222A5004372635 @default.
• W4308417222 hasAuthorship W4308417222A5030107320 @default.
• W4308417222 hasAuthorship W4308417222A5053452393 @default.
• W4308417222 hasAuthorship W4308417222A5060963546 @default.
• W4308417222 hasAuthorship W4308417222A5062542913 @default.
• W4308417222 hasAuthorship W4308417222A5062642226 @default.
• W4308417222 hasAuthorship W4308417222A5071404986 @default.
• W4308417222 hasAuthorship W4308417222A5075515056 @default.
• W4308417222 hasBestOaLocation W43084172221 @default.
• W4308417222 hasConcept C118487528 @default.
• W4308417222 hasConcept C142724271 @default.
• W4308417222 hasConcept C204232928 @default.
• W4308417222 hasConcept C2776403814 @default.
• W4308417222 hasConcept C2780495277 @default.
• W4308417222 hasConcept C2780827179 @default.
• W4308417222 hasConcept C71924100 @default.
• W4308417222 hasConcept C72563966 @default.
• W4308417222 hasConceptScore W4308417222C118487528 @default.
• W4308417222 hasConceptScore W4308417222C142724271 @default.
• W4308417222 hasConceptScore W4308417222C204232928 @default.
• W4308417222 hasConceptScore W4308417222C2776403814 @default.

• next