FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308430094> ?p ?o ?g. }

• W4308430094 abstract "Immunocyte infiltration and cytotoxicity play critical roles in both inflammation and immunotherapy. However, current cancer immunotherapy screening methods overlook the capacity of the T cells to penetrate the tumor stroma, thereby significantly limiting the development of effective treatments for solid tumors. Here, we present an automated high-throughput microfluidic platform for simultaneous tracking of the dynamics of T cell infiltration and cytotoxicity within the 3D tumor cultures with a tunable stromal makeup. By recourse to a clinical tumor-infiltrating lymphocyte (TIL) score analyzer, which is based on a clinical data-driven deep learning method, our platform can evaluate the efficacy of each treatment based on the scoring of T cell infiltration patterns. By screening a drug library using this technology, we identified an epigenetic drug (lysine-specific histone demethylase 1 inhibitor, LSD1i) that effectively promoted T cell tumor infiltration and enhanced treatment efficacy in combination with an immune checkpoint inhibitor (anti-PD1) in vivo. We demonstrated an automated system and strategy for screening immunocyte-solid tumor interactions, enabling the discovery of immuno- and combination therapies." @default.
• W4308430094 created "2022-11-11" @default.
• W4308430094 creator A5003530881 @default.
• W4308430094 creator A5003857474 @default.
• W4308430094 creator A5003972456 @default.
• W4308430094 creator A5027245585 @default.
• W4308430094 creator A5035361537 @default.
• W4308430094 creator A5054059500 @default.
• W4308430094 creator A5078628072 @default.
• W4308430094 creator A5081753593 @default.
• W4308430094 creator A5082943207 @default.
• W4308430094 creator A5083874307 @default.
• W4308430094 creator A5087945394 @default.
• W4308430094 creator A5089981582 @default.
• W4308430094 date "2022-11-07" @default.
• W4308430094 modified "2023-10-11" @default.
• W4308430094 title "Microfluidics guided by deep learning for cancer immunotherapy screening" @default.
• W4308430094 cites W1868820697 @default.
• W4308430094 cites W1965037168 @default.
• W4308430094 cites W1990675339 @default.
• W4308430094 cites W2019558320 @default.
• W4308430094 cites W2049491375 @default.
• W4308430094 cites W2078197336 @default.
• W4308430094 cites W2142300779 @default.
• W4308430094 cites W2157058802 @default.
• W4308430094 cites W2332155194 @default.
• W4308430094 cites W2419278168 @default.
• W4308430094 cites W2572174216 @default.
• W4308430094 cites W2590146273 @default.
• W4308430094 cites W2761668583 @default.
• W4308430094 cites W2774935716 @default.
• W4308430094 cites W2779221466 @default.
• W4308430094 cites W2796409016 @default.
• W4308430094 cites W2799444748 @default.
• W4308430094 cites W2799460884 @default.
• W4308430094 cites W2809237949 @default.
• W4308430094 cites W2885441485 @default.
• W4308430094 cites W2885650843 @default.
• W4308430094 cites W2894490018 @default.
• W4308430094 cites W2894609651 @default.
• W4308430094 cites W2905592635 @default.
• W4308430094 cites W2915390763 @default.
• W4308430094 cites W2963936065 @default.
• W4308430094 cites W3011410517 @default.
• W4308430094 cites W3033755050 @default.
• W4308430094 cites W4281568953 @default.
• W4308430094 cites W4285173503 @default.
• W4308430094 doi "https://doi.org/10.1073/pnas.2214569119" @default.
• W4308430094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36343225" @default.
• W4308430094 hasPublicationYear "2022" @default.
• W4308430094 type Work @default.
• W4308430094 citedByCount "10" @default.
• W4308430094 countsByYear W43084300942022 @default.
• W4308430094 countsByYear W43084300942023 @default.
• W4308430094 crossrefType "journal-article" @default.
• W4308430094 hasAuthorship W4308430094A5003530881 @default.
• W4308430094 hasAuthorship W4308430094A5003857474 @default.
• W4308430094 hasAuthorship W4308430094A5003972456 @default.
• W4308430094 hasAuthorship W4308430094A5027245585 @default.
• W4308430094 hasAuthorship W4308430094A5035361537 @default.
• W4308430094 hasAuthorship W4308430094A5054059500 @default.
• W4308430094 hasAuthorship W4308430094A5078628072 @default.
• W4308430094 hasAuthorship W4308430094A5081753593 @default.
• W4308430094 hasAuthorship W4308430094A5082943207 @default.
• W4308430094 hasAuthorship W4308430094A5083874307 @default.
• W4308430094 hasAuthorship W4308430094A5087945394 @default.
• W4308430094 hasAuthorship W4308430094A5089981582 @default.
• W4308430094 hasBestOaLocation W43084300941 @default.
• W4308430094 hasConcept C109316439 @default.
• W4308430094 hasConcept C153400128 @default.
• W4308430094 hasConcept C159985019 @default.
• W4308430094 hasConcept C16930146 @default.
• W4308430094 hasConcept C192562407 @default.
• W4308430094 hasConcept C202751555 @default.
• W4308430094 hasConcept C203014093 @default.
• W4308430094 hasConcept C204232928 @default.
• W4308430094 hasConcept C2776107976 @default.
• W4308430094 hasConcept C2777701055 @default.
• W4308430094 hasConcept C2778326572 @default.
• W4308430094 hasConcept C2780674031 @default.
• W4308430094 hasConcept C502942594 @default.
• W4308430094 hasConcept C52124034 @default.
• W4308430094 hasConcept C55493867 @default.
• W4308430094 hasConcept C71924100 @default.
• W4308430094 hasConcept C86803240 @default.
• W4308430094 hasConcept C8891405 @default.
• W4308430094 hasConceptScore W4308430094C109316439 @default.
• W4308430094 hasConceptScore W4308430094C153400128 @default.
• W4308430094 hasConceptScore W4308430094C159985019 @default.
• W4308430094 hasConceptScore W4308430094C16930146 @default.
• W4308430094 hasConceptScore W4308430094C192562407 @default.
• W4308430094 hasConceptScore W4308430094C202751555 @default.
• W4308430094 hasConceptScore W4308430094C203014093 @default.
• W4308430094 hasConceptScore W4308430094C204232928 @default.
• W4308430094 hasConceptScore W4308430094C2776107976 @default.
• W4308430094 hasConceptScore W4308430094C2777701055 @default.
• W4308430094 hasConceptScore W4308430094C2778326572 @default.
• W4308430094 hasConceptScore W4308430094C2780674031 @default.
• W4308430094 hasConceptScore W4308430094C502942594 @default.
• W4308430094 hasConceptScore W4308430094C52124034 @default.

• next