FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308434008> ?p ?o ?g. }

• W4308434008 endingPage "e2240665" @default.
• W4308434008 startingPage "e2240665" @default.
• W4308434008 abstract "Importance Racial disparities in cardiometabolic health are consistently observed in cohort studies. However, most studies neither evaluate differences in age at onset nor account for systematic exclusion stemming from “weathering” (accelerated health declines for minoritized groups due to structural social and economic marginalization). Objective To evaluate racial or ethnic disparities in age at onset of 4 cardiometabolic outcomes (hypertension, isolated systolic hypertension [ISH], insulin resistance [IR], and diabetes), accounting for multiple forms of potential selection bias. Design, Setting, and Participants This cohort study used data from the Study of Women’s Health Across the Nation longitudinal cohort (1995-2016) and a cross-sectional screening sample (1995-1997). Data were analyzed from July 2019 to October 2021. Participants were eligible for the cohort if they were aged 42 to 52 years, had not received hormone therapy in the past 3 months, were not pregnant, had an intact uterus and at least 1 ovary, and were premenopausal or early perimenopausal (most recent menses ≤3 months). Exposures Self-reported racial or ethnic group (Black, Chinese, Hispanic, Japanese, or White). Main Outcomes and Measures The main outcomes were hypertension (systolic blood pressure [BP] ≥140 mm Hg and diastolic BP ≥90 mm Hg or use of antihypertensive medication), ISH (systolic BP ≥140 mm Hg and diastolic BP &amp;lt;90 mm Hg or use of antihypertensive medication), IR (homeostasis model assessment for IR value &amp;gt;5.9 or insulin use), and diabetes (fasting serum glucose level ≥126 mg/dL [to convert to mmol/L, multiply by 0.0555], use of insulin or oral antidiabetic medication, or physician diagnosis). Selection into the cohort was addressed via inverse probability weighting and interval-censored survival models and selection out via multiple imputation. Accelerated failure time models were used to examine racial or ethnic differences in age at disease onset and estimate the median age at onset. Results A total of 3302 women were included in the study, with a median age of 46.2 years (range, 42-52 years) at baseline. In the sample, 42.6% had a bachelor’s degree or higher and 36.3% self-rated their health as “very good” at baseline; 23.9% had hypertension, 43.7% had ISH, 13.5% had IR, and 4.6% had diabetes at baseline. Hypertension occurred a median of 5.0 years (95% CI, 5.4-5.5 years) earlier and metabolic outcomes (diabetes and IR) a median of 11.3 years (95% CI, 9.7-12.9 years) earlier for Black and Hispanic women vs White women; ISH occurred a median of 7.7 years (95% CI, 7.3-8.1 years) earlier for Black women vs White women. Adjustment for selection was associated with a mean 20-year decrease in estimated median age at onset, with greater decreases among Black and Hispanic women. Conclusions and Relevance In this multiracial cohort of midlife women, failure to account for selection biases, especially at study onset, was associated with falsely high estimates of age at cardiometabolic onset, with greater misestimation among Black and Hispanic women. The results suggest that hypertension and metabolic interventions, particularly for Black and Hispanic women, should be targeted to women aged as young as 30 years for hypertension and 40 years for metabolic interventions. Considering the timing of disease and fully addressing inherent selection biases in research are critical to understanding aging and disease risk, especially for racial and ethnic minoritized populations." @default.
• W4308434008 created "2022-11-11" @default.
• W4308434008 creator A5015181811 @default.
• W4308434008 creator A5037727003 @default.
• W4308434008 creator A5038684450 @default.
• W4308434008 creator A5050725165 @default.
• W4308434008 creator A5057706291 @default.
• W4308434008 creator A5070790251 @default.
• W4308434008 date "2022-11-07" @default.
• W4308434008 modified "2023-10-18" @default.
• W4308434008 title "Study Selection Bias and Racial or Ethnic Disparities in Estimated Age at Onset of Cardiometabolic Disease Among Midlife Women in the US" @default.
• W4308434008 cites W1501269999 @default.
• W4308434008 cites W1511606218 @default.
• W4308434008 cites W1520569529 @default.
• W4308434008 cites W1754691347 @default.
• W4308434008 cites W1972264001 @default.
• W4308434008 cites W1978209044 @default.
• W4308434008 cites W1999745316 @default.
• W4308434008 cites W2010812479 @default.
• W4308434008 cites W2038565815 @default.
• W4308434008 cites W2042026350 @default.
• W4308434008 cites W2047697609 @default.
• W4308434008 cites W2077052657 @default.
• W4308434008 cites W2077483319 @default.
• W4308434008 cites W2091199365 @default.
• W4308434008 cites W2123828906 @default.
• W4308434008 cites W2130688509 @default.
• W4308434008 cites W2143954917 @default.
• W4308434008 cites W2151451975 @default.
• W4308434008 cites W2160254383 @default.
• W4308434008 cites W2171478866 @default.
• W4308434008 cites W2182570550 @default.
• W4308434008 cites W2476092673 @default.
• W4308434008 cites W2523495956 @default.
• W4308434008 cites W2607031541 @default.
• W4308434008 cites W2883926720 @default.
• W4308434008 cites W2904190147 @default.
• W4308434008 cites W2911742453 @default.
• W4308434008 cites W4210311460 @default.
• W4308434008 cites W4210854013 @default.
• W4308434008 cites W4234657925 @default.
• W4308434008 cites W4240985810 @default.
• W4308434008 cites W4248126245 @default.
• W4308434008 cites W4288037966 @default.
• W4308434008 cites W4292764096 @default.
• W4308434008 doi "https://doi.org/10.1001/jamanetworkopen.2022.40665" @default.
• W4308434008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36342714" @default.
• W4308434008 hasPublicationYear "2022" @default.
• W4308434008 type Work @default.
• W4308434008 citedByCount "0" @default.
• W4308434008 crossrefType "journal-article" @default.
• W4308434008 hasAuthorship W4308434008A5015181811 @default.
• W4308434008 hasAuthorship W4308434008A5037727003 @default.
• W4308434008 hasAuthorship W4308434008A5038684450 @default.
• W4308434008 hasAuthorship W4308434008A5050725165 @default.
• W4308434008 hasAuthorship W4308434008A5057706291 @default.
• W4308434008 hasAuthorship W4308434008A5070790251 @default.
• W4308434008 hasBestOaLocation W43084340081 @default.
• W4308434008 hasConcept C126322002 @default.
• W4308434008 hasConcept C134018914 @default.
• W4308434008 hasConcept C144024400 @default.
• W4308434008 hasConcept C149923435 @default.
• W4308434008 hasConcept C201903717 @default.
• W4308434008 hasConcept C2777391703 @default.
• W4308434008 hasConcept C555293320 @default.
• W4308434008 hasConcept C71924100 @default.
• W4308434008 hasConcept C72563966 @default.
• W4308434008 hasConcept C84393581 @default.
• W4308434008 hasConceptScore W4308434008C126322002 @default.
• W4308434008 hasConceptScore W4308434008C134018914 @default.
• W4308434008 hasConceptScore W4308434008C144024400 @default.
• W4308434008 hasConceptScore W4308434008C149923435 @default.
• W4308434008 hasConceptScore W4308434008C201903717 @default.
• W4308434008 hasConceptScore W4308434008C2777391703 @default.
• W4308434008 hasConceptScore W4308434008C555293320 @default.
• W4308434008 hasConceptScore W4308434008C71924100 @default.
• W4308434008 hasConceptScore W4308434008C72563966 @default.
• W4308434008 hasConceptScore W4308434008C84393581 @default.
• W4308434008 hasIssue "11" @default.
• W4308434008 hasLocation W43084340081 @default.
• W4308434008 hasLocation W43084340082 @default.
• W4308434008 hasLocation W43084340083 @default.
• W4308434008 hasOpenAccess W4308434008 @default.
• W4308434008 hasPrimaryLocation W43084340081 @default.
• W4308434008 hasRelatedWork W1979252938 @default.
• W4308434008 hasRelatedWork W2032225465 @default.
• W4308434008 hasRelatedWork W2044823377 @default.
• W4308434008 hasRelatedWork W2169206971 @default.
• W4308434008 hasRelatedWork W2378290744 @default.
• W4308434008 hasRelatedWork W2391899759 @default.
• W4308434008 hasRelatedWork W2584731720 @default.
• W4308434008 hasRelatedWork W2886303208 @default.
• W4308434008 hasRelatedWork W2910989958 @default.
• W4308434008 hasRelatedWork W2969331335 @default.
• W4308434008 hasVolume "5" @default.
• W4308434008 isParatext "false" @default.
• W4308434008 isRetracted "false" @default.
• W4308434008 workType "article" @default.