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- W4308434550 abstract "ATG9A and ATG2A are essential core members of the autophagy machinery. ATG9A is a lipid scramblase that allows equilibration of lipids across a membrane bilayer, whereas ATG2A facilitates lipid flow between tethered membranes. Although both have been functionally linked during the formation of autophagosomes, the molecular details and consequences of their interaction remain unclear. By combining data from peptide arrays, crosslinking, and hydrogen-deuterium exchange mass spectrometry together with cryoelectron microscopy, we propose a molecular model of the ATG9A-2A complex. Using this integrative structure modeling approach, we identify several interfaces mediating ATG9A-2A interaction that would allow a direct transfer of lipids from ATG2A into the lipid-binding perpendicular branch of ATG9A. Mutational analyses combined with functional activity assays demonstrate their importance for autophagy, thereby shedding light on this protein complex at the heart of autophagy." @default.
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- W4308434550 date "2022-11-01" @default.
- W4308434550 modified "2023-10-16" @default.
- W4308434550 title "ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation" @default.
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- W4308434550 doi "https://doi.org/10.1016/j.molcel.2022.10.017" @default.
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