FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308442328> ?p ?o ?g. }

• W4308442328 abstract "Evodiamine (EVO) is one of the main components extracted from <em>Evodia rutaecarpa</em> and has been reported to inhibit tumor growth by inhibiting proliferation and inducing apoptosis. Although the anticancer activity of evodiamine has been confirmed, the exact mechanism remains to be elucidated. In the present study, cancer stem‑like cells (CSCs) were successfully enriched from A549 cells by being cultured in serum‑free medium and characterized by detecting stemness markers. Expectedly, the addition of EVO inhibited proliferation, migration and invasion in A549 cells, demonstrating its inhibitory effects on the malignant behaviors of A549 cells. In CSCs derived from A549 cells, EVO treatment promoted cell proliferation while inhibiting migration and invasion. By detecting the hallmarks of the epithelial‑mesenchymal transition (EMT), including E‑cadherin, Vimentin, Slug and Snail via western blotting, it was revealed that EVO treatment inactivated the EMT process and potentially led to the loss of self‑renewal capacity of CSCs and promoted proliferation. By activating the EMT using TGF‑β pretreatment, EVO treatment downregulated the hallmarks of the EMT and led to inactivation of the EMT, indicating its potential mechanism of regulating CSCs via the EMT pathway. The findings suggested that modulation of the self‑renewal capacity of CSCs may affect malignant cancer behaviors following surgery. EVO exerts inhibitory effects not only on cancer cells but also on CSCs in non‑small‑cell lung cancer, and therefore could be used as a promising drug targeting CSCs." @default.
• W4308442328 created "2022-11-11" @default.
• W4308442328 creator A5026369750 @default.
• W4308442328 creator A5047333154 @default.
• W4308442328 creator A5052052129 @default.
• W4308442328 creator A5055875257 @default.
• W4308442328 date "2022-11-07" @default.
• W4308442328 modified "2023-10-15" @default.
• W4308442328 title "Evodiamine exerts inhibitory roles in non‑small cell lung cancer cell A549 and its sub‑population of stem‑like cells" @default.
• W4308442328 cites W1978072703 @default.
• W4308442328 cites W1981989535 @default.
• W4308442328 cites W1985339653 @default.
• W4308442328 cites W1992514491 @default.
• W4308442328 cites W1994599132 @default.
• W4308442328 cites W2001741750 @default.
• W4308442328 cites W2005701343 @default.
• W4308442328 cites W2013315155 @default.
• W4308442328 cites W2014691022 @default.
• W4308442328 cites W2024919757 @default.
• W4308442328 cites W2039410393 @default.
• W4308442328 cites W2049217551 @default.
• W4308442328 cites W2064717188 @default.
• W4308442328 cites W2068416436 @default.
• W4308442328 cites W2084487780 @default.
• W4308442328 cites W2100989340 @default.
• W4308442328 cites W2102085111 @default.
• W4308442328 cites W2107277218 @default.
• W4308442328 cites W2127289044 @default.
• W4308442328 cites W2143899065 @default.
• W4308442328 cites W2167280954 @default.
• W4308442328 cites W2169983495 @default.
• W4308442328 cites W2175576302 @default.
• W4308442328 cites W2192080449 @default.
• W4308442328 cites W2517441860 @default.
• W4308442328 doi "https://doi.org/10.3892/etm.2022.11682" @default.
• W4308442328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36561974" @default.
• W4308442328 hasPublicationYear "2022" @default.
• W4308442328 type Work @default.
• W4308442328 citedByCount "1" @default.
• W4308442328 countsByYear W43084423282023 @default.
• W4308442328 crossrefType "journal-article" @default.
• W4308442328 hasAuthorship W4308442328A5026369750 @default.
• W4308442328 hasAuthorship W4308442328A5047333154 @default.
• W4308442328 hasAuthorship W4308442328A5052052129 @default.
• W4308442328 hasAuthorship W4308442328A5055875257 @default.
• W4308442328 hasBestOaLocation W43084423281 @default.
• W4308442328 hasConcept C121608353 @default.
• W4308442328 hasConcept C137738243 @default.
• W4308442328 hasConcept C147447768 @default.
• W4308442328 hasConcept C1491633281 @default.
• W4308442328 hasConcept C185592680 @default.
• W4308442328 hasConcept C190283241 @default.
• W4308442328 hasConcept C203014093 @default.
• W4308442328 hasConcept C204232928 @default.
• W4308442328 hasConcept C2779013556 @default.
• W4308442328 hasConcept C2779883843 @default.
• W4308442328 hasConcept C2781018059 @default.
• W4308442328 hasConcept C28328180 @default.
• W4308442328 hasConcept C2908647359 @default.
• W4308442328 hasConcept C29537977 @default.
• W4308442328 hasConcept C502942594 @default.
• W4308442328 hasConcept C54355233 @default.
• W4308442328 hasConcept C55427017 @default.
• W4308442328 hasConcept C55493867 @default.
• W4308442328 hasConcept C62112901 @default.
• W4308442328 hasConcept C71924100 @default.
• W4308442328 hasConcept C76419328 @default.
• W4308442328 hasConcept C81729549 @default.
• W4308442328 hasConcept C86803240 @default.
• W4308442328 hasConcept C95444343 @default.
• W4308442328 hasConcept C96232424 @default.
• W4308442328 hasConcept C98274493 @default.
• W4308442328 hasConcept C99454951 @default.
• W4308442328 hasConceptScore W4308442328C121608353 @default.
• W4308442328 hasConceptScore W4308442328C137738243 @default.
• W4308442328 hasConceptScore W4308442328C147447768 @default.
• W4308442328 hasConceptScore W4308442328C1491633281 @default.
• W4308442328 hasConceptScore W4308442328C185592680 @default.
• W4308442328 hasConceptScore W4308442328C190283241 @default.
• W4308442328 hasConceptScore W4308442328C203014093 @default.
• W4308442328 hasConceptScore W4308442328C204232928 @default.
• W4308442328 hasConceptScore W4308442328C2779013556 @default.
• W4308442328 hasConceptScore W4308442328C2779883843 @default.
• W4308442328 hasConceptScore W4308442328C2781018059 @default.
• W4308442328 hasConceptScore W4308442328C28328180 @default.
• W4308442328 hasConceptScore W4308442328C2908647359 @default.
• W4308442328 hasConceptScore W4308442328C29537977 @default.
• W4308442328 hasConceptScore W4308442328C502942594 @default.
• W4308442328 hasConceptScore W4308442328C54355233 @default.
• W4308442328 hasConceptScore W4308442328C55427017 @default.
• W4308442328 hasConceptScore W4308442328C55493867 @default.
• W4308442328 hasConceptScore W4308442328C62112901 @default.
• W4308442328 hasConceptScore W4308442328C71924100 @default.
• W4308442328 hasConceptScore W4308442328C76419328 @default.
• W4308442328 hasConceptScore W4308442328C81729549 @default.
• W4308442328 hasConceptScore W4308442328C86803240 @default.
• W4308442328 hasConceptScore W4308442328C95444343 @default.
• W4308442328 hasConceptScore W4308442328C96232424 @default.
• W4308442328 hasConceptScore W4308442328C98274493 @default.
• W4308442328 hasConceptScore W4308442328C99454951 @default.

• next