Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308443703> ?p ?o ?g. }
- W4308443703 endingPage "2188" @default.
- W4308443703 startingPage "2188" @default.
- W4308443703 abstract "Skin wound healing is a complex process that requires the mutual work of cellular and molecular agents to promote tissue restoration. In order to improve such a process, especially in cases of impaired healing (e.g., diabetic ulcer, chronic wounds), there is a search for substances with healing properties and low toxicity: two features that some natural products—such as the bee product named propolis—exhibit. Propolis is a resinous substance obtained from plant resins and exudates with antioxidant, anti-inflammatory, and antitumoral activities, among other biological ones. Based on the previously reported healing actions of different types of propolis, the Brazilian red propolis (BRP) was tested for this matter. A skin wound excision model in male Wistar rats was performed using two topical formulations with 1% red propolis as treatments: hydroalcoholic extract and Paste. Macroscopical, histological and immunohistochemical analysis were performed, revealing that red propolis enhanced wound contraction, epithelialization, reduced crust formation, and modulated the distribution of healing associated factors, mainly collagen I, collagen III, MMP-9, TGF-β3 and VEGF. Biochemical analysis with the antioxidants SOD, MPO, GSH and GR showed that propolis acts similarly to the positive control, collagenase, increasing these molecules’ activity. These results suggest that BRP promotes enhanced wound healing by modulating growth factors and antioxidant molecules related to cutaneous wound healing." @default.
- W4308443703 created "2022-11-11" @default.
- W4308443703 creator A5009835476 @default.
- W4308443703 creator A5017952023 @default.
- W4308443703 creator A5022870772 @default.
- W4308443703 creator A5024133000 @default.
- W4308443703 creator A5039582010 @default.
- W4308443703 creator A5059800982 @default.
- W4308443703 creator A5061423666 @default.
- W4308443703 creator A5079090531 @default.
- W4308443703 creator A5086654264 @default.
- W4308443703 creator A5088015788 @default.
- W4308443703 date "2022-11-04" @default.
- W4308443703 modified "2023-10-06" @default.
- W4308443703 title "Histological, Immunohistochemical and Antioxidant Analysis of Skin Wound Healing Influenced by the Topical Application of Brazilian Red Propolis" @default.
- W4308443703 cites W146607653 @default.
- W4308443703 cites W1982089960 @default.
- W4308443703 cites W1988897543 @default.
- W4308443703 cites W2001054302 @default.
- W4308443703 cites W2016157515 @default.
- W4308443703 cites W2023805473 @default.
- W4308443703 cites W2033657576 @default.
- W4308443703 cites W2035542907 @default.
- W4308443703 cites W2048243867 @default.
- W4308443703 cites W2067916185 @default.
- W4308443703 cites W2068933459 @default.
- W4308443703 cites W2099540110 @default.
- W4308443703 cites W2106704635 @default.
- W4308443703 cites W2118859335 @default.
- W4308443703 cites W2127366925 @default.
- W4308443703 cites W2130631177 @default.
- W4308443703 cites W2145579888 @default.
- W4308443703 cites W2184165915 @default.
- W4308443703 cites W2191388985 @default.
- W4308443703 cites W2197332903 @default.
- W4308443703 cites W2220643393 @default.
- W4308443703 cites W2394780405 @default.
- W4308443703 cites W2528512521 @default.
- W4308443703 cites W2559968356 @default.
- W4308443703 cites W2566399670 @default.
- W4308443703 cites W2574904481 @default.
- W4308443703 cites W2736342734 @default.
- W4308443703 cites W2747824692 @default.
- W4308443703 cites W2775860365 @default.
- W4308443703 cites W2782959446 @default.
- W4308443703 cites W2784327305 @default.
- W4308443703 cites W2800408434 @default.
- W4308443703 cites W2802667260 @default.
- W4308443703 cites W2804229395 @default.
- W4308443703 cites W2883076690 @default.
- W4308443703 cites W2886718594 @default.
- W4308443703 cites W2892727393 @default.
- W4308443703 cites W2898343720 @default.
- W4308443703 cites W2905363830 @default.
- W4308443703 cites W2915171406 @default.
- W4308443703 cites W2922360292 @default.
- W4308443703 cites W2948978255 @default.
- W4308443703 cites W2949270986 @default.
- W4308443703 cites W2956485347 @default.
- W4308443703 cites W2972031537 @default.
- W4308443703 cites W2972894248 @default.
- W4308443703 cites W2980360512 @default.
- W4308443703 cites W2992038267 @default.
- W4308443703 cites W2996391241 @default.
- W4308443703 cites W3001644817 @default.
- W4308443703 cites W3002390066 @default.
- W4308443703 cites W3004422145 @default.
- W4308443703 cites W3011366455 @default.
- W4308443703 cites W3011435677 @default.
- W4308443703 cites W3016647148 @default.
- W4308443703 cites W3022236569 @default.
- W4308443703 cites W3023602176 @default.
- W4308443703 cites W3031947977 @default.
- W4308443703 cites W3040225007 @default.
- W4308443703 cites W3045063353 @default.
- W4308443703 cites W3047104964 @default.
- W4308443703 cites W3088424275 @default.
- W4308443703 cites W3109291030 @default.
- W4308443703 cites W3127835035 @default.
- W4308443703 cites W3131954587 @default.
- W4308443703 cites W3136686485 @default.
- W4308443703 cites W3138455354 @default.
- W4308443703 cites W3162290153 @default.
- W4308443703 cites W3169634808 @default.
- W4308443703 cites W4200483069 @default.
- W4308443703 cites W4210530356 @default.
- W4308443703 cites W4211188219 @default.
- W4308443703 cites W4283516810 @default.
- W4308443703 cites W4283780132 @default.
- W4308443703 cites W4285585222 @default.
- W4308443703 cites W4295757109 @default.
- W4308443703 doi "https://doi.org/10.3390/antiox11112188" @default.
- W4308443703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36358560" @default.
- W4308443703 hasPublicationYear "2022" @default.
- W4308443703 type Work @default.
- W4308443703 citedByCount "2" @default.
- W4308443703 countsByYear W43084437032023 @default.
- W4308443703 crossrefType "journal-article" @default.