Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308444938> ?p ?o ?g. }
- W4308444938 abstract "Diclofenac etalhyaluronate (DF-HA) is a recently developed analgesic conjugate of diclofenac and hyaluronic acid that has analgesic and anti-inflammatory effects on acute arthritis. In this study, we investigated its analgesic effect on osteoarthritis, using a rat model of monoiodoacetate (MIA).We injected MIA into the right knees of eight 6-weeks-old male Sprague-Dawley rats. Four weeks later, rats were randomly injected with DF-HA or vehicle into the right knee. Seven weeks after the MIA injection, fluorogold (FG) and sterile saline were injected into the right knees of all the rats. We assessed hyperalgesia with weekly von Frey tests for 8 weeks after MIA administration. We took the right knee computed tomography (CT) as radiographical evaluation every 2 weeks. All rats were sacrificed 8 weeks after administration of MIA for histological evaluation of the right knee and immunohistochemical evaluation of the DRG and spinal cord. We also evaluated the number of FG-labeled calcitonin gene-related peptide (CGRP)-immunoreactive(ir) neurons in the dorsal root ganglion (DRG) and ionized calcium-binding adapter molecule 1 (Iba1)-ir microglia in the spinal cord.Administration of DF-HA significantly improved pain sensitivity and reduced CGRP and Iba1 expression in the DRG and spinal cord, respectively. However, computed tomography and histological evaluation of the right knee showed similar levels of joint deformity, despite DF-HA administration.DF-HA exerted analgesic effects on osteoarthritic pain, but did not affect joint deformity." @default.
- W4308444938 created "2022-11-11" @default.
- W4308444938 creator A5007648765 @default.
- W4308444938 creator A5011530088 @default.
- W4308444938 creator A5013578408 @default.
- W4308444938 creator A5019099819 @default.
- W4308444938 creator A5022362986 @default.
- W4308444938 creator A5022621865 @default.
- W4308444938 creator A5023268743 @default.
- W4308444938 creator A5029887209 @default.
- W4308444938 creator A5033114953 @default.
- W4308444938 creator A5033366805 @default.
- W4308444938 creator A5034804236 @default.
- W4308444938 creator A5037591579 @default.
- W4308444938 creator A5042113287 @default.
- W4308444938 creator A5046070382 @default.
- W4308444938 creator A5046201982 @default.
- W4308444938 creator A5050939126 @default.
- W4308444938 creator A5059430484 @default.
- W4308444938 creator A5059705418 @default.
- W4308444938 creator A5067610895 @default.
- W4308444938 creator A5072359896 @default.
- W4308444938 creator A5073733659 @default.
- W4308444938 creator A5079176046 @default.
- W4308444938 creator A5081087597 @default.
- W4308444938 creator A5081299624 @default.
- W4308444938 creator A5087889642 @default.
- W4308444938 date "2022-11-07" @default.
- W4308444938 modified "2023-09-26" @default.
- W4308444938 title "Analgesic effects and arthritic changes following intra-articular injection of diclofenac etalhyaluronate in a rat knee osteoarthritis model" @default.
- W4308444938 cites W155719443 @default.
- W4308444938 cites W1574811776 @default.
- W4308444938 cites W168176600 @default.
- W4308444938 cites W1747652819 @default.
- W4308444938 cites W1831989259 @default.
- W4308444938 cites W1967057044 @default.
- W4308444938 cites W1967113556 @default.
- W4308444938 cites W1984981145 @default.
- W4308444938 cites W1991326865 @default.
- W4308444938 cites W1993397513 @default.
- W4308444938 cites W1999087512 @default.
- W4308444938 cites W2003830841 @default.
- W4308444938 cites W2006864238 @default.
- W4308444938 cites W2011909645 @default.
- W4308444938 cites W2036242628 @default.
- W4308444938 cites W2040299229 @default.
- W4308444938 cites W2043870138 @default.
- W4308444938 cites W2050303640 @default.
- W4308444938 cites W2071754001 @default.
- W4308444938 cites W2080326541 @default.
- W4308444938 cites W2099427592 @default.
- W4308444938 cites W2113389055 @default.
- W4308444938 cites W2117040516 @default.
- W4308444938 cites W2131985503 @default.
- W4308444938 cites W2141391452 @default.
- W4308444938 cites W2172201406 @default.
- W4308444938 cites W2285319279 @default.
- W4308444938 cites W2395467752 @default.
- W4308444938 cites W2508876487 @default.
- W4308444938 cites W2755625524 @default.
- W4308444938 cites W2771085616 @default.
- W4308444938 cites W2800508734 @default.
- W4308444938 cites W2803067976 @default.
- W4308444938 cites W2805724878 @default.
- W4308444938 cites W2808097672 @default.
- W4308444938 cites W2947378310 @default.
- W4308444938 cites W3013877859 @default.
- W4308444938 cites W3081792376 @default.
- W4308444938 cites W3091539217 @default.
- W4308444938 cites W3134733827 @default.
- W4308444938 cites W3138756724 @default.
- W4308444938 cites W3165516526 @default.
- W4308444938 cites W3211879702 @default.
- W4308444938 cites W4210617127 @default.
- W4308444938 cites W4224274129 @default.
- W4308444938 cites W4281493637 @default.
- W4308444938 doi "https://doi.org/10.1186/s12891-022-05937-y" @default.
- W4308444938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36344944" @default.
- W4308444938 hasPublicationYear "2022" @default.
- W4308444938 type Work @default.
- W4308444938 citedByCount "0" @default.
- W4308444938 crossrefType "journal-article" @default.
- W4308444938 hasAuthorship W4308444938A5007648765 @default.
- W4308444938 hasAuthorship W4308444938A5011530088 @default.
- W4308444938 hasAuthorship W4308444938A5013578408 @default.
- W4308444938 hasAuthorship W4308444938A5019099819 @default.
- W4308444938 hasAuthorship W4308444938A5022362986 @default.
- W4308444938 hasAuthorship W4308444938A5022621865 @default.
- W4308444938 hasAuthorship W4308444938A5023268743 @default.
- W4308444938 hasAuthorship W4308444938A5029887209 @default.
- W4308444938 hasAuthorship W4308444938A5033114953 @default.
- W4308444938 hasAuthorship W4308444938A5033366805 @default.
- W4308444938 hasAuthorship W4308444938A5034804236 @default.
- W4308444938 hasAuthorship W4308444938A5037591579 @default.
- W4308444938 hasAuthorship W4308444938A5042113287 @default.
- W4308444938 hasAuthorship W4308444938A5046070382 @default.
- W4308444938 hasAuthorship W4308444938A5046201982 @default.
- W4308444938 hasAuthorship W4308444938A5050939126 @default.
- W4308444938 hasAuthorship W4308444938A5059430484 @default.
- W4308444938 hasAuthorship W4308444938A5059705418 @default.