Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308446853> ?p ?o ?g. }
- W4308446853 endingPage "7575" @default.
- W4308446853 startingPage "7575" @default.
- W4308446853 abstract "A series of 11-substituted 3,5,10,11-tetrahydro-2H-benzo[6,7]thiochromeno[2,3-d][1,3]thiazole-2,5,10-triones were obtained via hetero-Diels-Alder reaction of 5-alkyl/arylallylidene/-4-thioxo-2-thiazolidinones and 1,4-naphthoquinones. The structures of newly synthesized compounds were established by spectral data and a single-crystal X-ray diffraction analysis. According to U.S. NCI protocols, compounds 3.5 and 3.6 were screened for their anticancer activity; 11-Phenethyl-3,11-dihydro-2H-benzo[6,7]thiochromeno[2,3-d]thiazole-2,5,10-trione (3.6) showed pronounced cytotoxic effect on leukemia (Jurkat, THP-1), epidermoid (KB3-1, KBC-1), and colon (HCT116wt, HCT116 p53-/-) cell lines. The cytotoxic action of 3.6 on p53-deficient colon carcinoma cells was two times weaker than on HCT116wt, and it may be an interesting feature of the mechanism action." @default.
- W4308446853 created "2022-11-12" @default.
- W4308446853 creator A5018379660 @default.
- W4308446853 creator A5023268906 @default.
- W4308446853 creator A5028688417 @default.
- W4308446853 creator A5032697098 @default.
- W4308446853 creator A5042033861 @default.
- W4308446853 creator A5043546894 @default.
- W4308446853 creator A5047002742 @default.
- W4308446853 creator A5047207873 @default.
- W4308446853 creator A5050670780 @default.
- W4308446853 creator A5061099284 @default.
- W4308446853 creator A5065115711 @default.
- W4308446853 creator A5067342860 @default.
- W4308446853 creator A5067788923 @default.
- W4308446853 creator A5073413350 @default.
- W4308446853 creator A5089318358 @default.
- W4308446853 creator A5089461396 @default.
- W4308446853 date "2022-11-04" @default.
- W4308446853 modified "2023-09-30" @default.
- W4308446853 title "1,4-Naphthoquinone Motif in the Synthesis of New Thiopyrano[2,3-d]thiazoles as Potential Biologically Active Compounds" @default.
- W4308446853 cites W1004617134 @default.
- W4308446853 cites W1592286099 @default.
- W4308446853 cites W1966868212 @default.
- W4308446853 cites W1969360633 @default.
- W4308446853 cites W1975539526 @default.
- W4308446853 cites W1980018731 @default.
- W4308446853 cites W1984570894 @default.
- W4308446853 cites W1984866351 @default.
- W4308446853 cites W1989999044 @default.
- W4308446853 cites W1990170643 @default.
- W4308446853 cites W1996817952 @default.
- W4308446853 cites W1997367417 @default.
- W4308446853 cites W2008096537 @default.
- W4308446853 cites W2013100936 @default.
- W4308446853 cites W2013734828 @default.
- W4308446853 cites W2017735546 @default.
- W4308446853 cites W2023748992 @default.
- W4308446853 cites W2027028554 @default.
- W4308446853 cites W2040680768 @default.
- W4308446853 cites W2054547999 @default.
- W4308446853 cites W2056873642 @default.
- W4308446853 cites W2059205366 @default.
- W4308446853 cites W2060581176 @default.
- W4308446853 cites W2064314006 @default.
- W4308446853 cites W2078002587 @default.
- W4308446853 cites W2078144380 @default.
- W4308446853 cites W2082214850 @default.
- W4308446853 cites W2087312216 @default.
- W4308446853 cites W2092931894 @default.
- W4308446853 cites W2095699993 @default.
- W4308446853 cites W2110804661 @default.
- W4308446853 cites W2116767488 @default.
- W4308446853 cites W2118909720 @default.
- W4308446853 cites W2132454074 @default.
- W4308446853 cites W2138215744 @default.
- W4308446853 cites W2145538332 @default.
- W4308446853 cites W2155208683 @default.
- W4308446853 cites W2167170343 @default.
- W4308446853 cites W2171093181 @default.
- W4308446853 cites W2190737133 @default.
- W4308446853 cites W2326651896 @default.
- W4308446853 cites W2328927583 @default.
- W4308446853 cites W2479348837 @default.
- W4308446853 cites W2606668432 @default.
- W4308446853 cites W2783569476 @default.
- W4308446853 cites W2788436116 @default.
- W4308446853 cites W2792895473 @default.
- W4308446853 cites W2888452818 @default.
- W4308446853 cites W2897208318 @default.
- W4308446853 cites W2914302308 @default.
- W4308446853 cites W2935962579 @default.
- W4308446853 cites W2947278790 @default.
- W4308446853 cites W2949471714 @default.
- W4308446853 cites W2964414741 @default.
- W4308446853 cites W2974658166 @default.
- W4308446853 cites W3005332017 @default.
- W4308446853 cites W3067582306 @default.
- W4308446853 cites W3210085405 @default.
- W4308446853 cites W4220935702 @default.
- W4308446853 cites W4225294462 @default.
- W4308446853 cites W4289755632 @default.
- W4308446853 doi "https://doi.org/10.3390/molecules27217575" @default.
- W4308446853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36364402" @default.
- W4308446853 hasPublicationYear "2022" @default.
- W4308446853 type Work @default.
- W4308446853 citedByCount "1" @default.
- W4308446853 countsByYear W43084468532023 @default.
- W4308446853 crossrefType "journal-article" @default.
- W4308446853 hasAuthorship W4308446853A5018379660 @default.
- W4308446853 hasAuthorship W4308446853A5023268906 @default.
- W4308446853 hasAuthorship W4308446853A5028688417 @default.
- W4308446853 hasAuthorship W4308446853A5032697098 @default.
- W4308446853 hasAuthorship W4308446853A5042033861 @default.
- W4308446853 hasAuthorship W4308446853A5043546894 @default.
- W4308446853 hasAuthorship W4308446853A5047002742 @default.
- W4308446853 hasAuthorship W4308446853A5047207873 @default.
- W4308446853 hasAuthorship W4308446853A5050670780 @default.