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- W4308447722 abstract "Triple-negative breast cancer (TNBC) exhibits high recurrence and mortality rates because of the lack of effective treatment targets. Surgery and traditional chemotherapy are the primary treatment options. Immunotherapy shows high potential for treating various cancers but exhibits limited efficacy against TNBC as a monotherapy. Chemoimmunotherapy has broad prospects for applications for cancer treatment conferred through the synergistic immunomodulatory and anti-tumor effects of chemotherapy and immunotherapeutic strategies. However, improving the efficacy of synergistic therapy and reducing the side effects of multiple drugs remain to be the main challenges in chemoimmunotherapy against TNBC. Nanocarriers can target both cancer and immune cells, promote drug accumulation, and show minimal toxicity, making them ideal delivery systems for chemotherapeutic and immunotherapeutic agents. In this review, we introduce the immunomodulatory effects of chemotherapy and combined mechanisms of chemoimmunotherapy, followed by a summary of nanoparticle-mediated chemoimmunotherapeutic strategies used for treating TNBC. This up-to-date synthesis of relevant findings in the field merits contemplation, while considering avenues of investigation to enable advances in the field." @default.
- W4308447722 created "2022-11-12" @default.
- W4308447722 creator A5029198767 @default.
- W4308447722 creator A5049497651 @default.
- W4308447722 creator A5058894305 @default.
- W4308447722 creator A5077119545 @default.
- W4308447722 creator A5084240171 @default.
- W4308447722 date "2022-11-01" @default.
- W4308447722 modified "2023-10-18" @default.
- W4308447722 title "Nanoparticles for Chemoimmunotherapy Against Triple-Negative Breast Cancer" @default.
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