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• W4308449901 abstract "Abstract Background The bacterial mechanisms responsible for hydrogen peroxide (H 2 O 2 ) scavenging have been well-reported, yet little is known about how bacteria isolated from cold-environments respond to H 2 O 2 stress. Therefore, we investigated the transcriptional profiling of the Planomicrobium strain AX6 strain isolated from the cold-desert ecosystem in the Qaidam Basin, Qinghai-Tibet Plateau, China, in response to H 2 O 2 stress aiming to uncover the molecular mechanisms associated with H 2 O 2 scavenging potential. Methods We investigated the H 2 O 2 -scavenging potential of the bacterial Planomicrobium strain AX6 isolated from the cold-desert ecosystem in the Qaidam Basin, Qinghai-Tibet Plateau, China. Furthermore, we used high-throughput RNA-sequencing to unravel the molecular aspects associated with the H 2 O 2 scavenging potential of the Planomicrobium strain AX6 isolate. Results In total, 3,427 differentially expressed genes (DEGs) were identified in Planomicrobium strain AX6 isolate in response to 4 h of H 2 O 2 (1.5 mM) exposure. Besides, Kyoto Encyclopedia of Genes and Genomes pathway and Gene Ontology analyses revealed the down- and/or up-regulated pathways following H 2 O 2 treatment. Our study not only identified the H 2 O 2 scavenging capability of the strain nevertheless also a range of mechanisms to cope with the toxic effect of H 2 O 2 through genes involved in oxidative stress response. Compared to control, several genes coding for antioxidant proteins, including glutathione peroxidase (GSH-Px), Coproporphyrinogen III oxidase, and superoxide dismutase (SOD), were relatively up-regulated in Planomicrobium strain AX6, when exposed to H 2 O 2 . Conclusions Overall, the results suggest that the up-regulated genes responsible for antioxidant defense pathways serve as essential regulatory mechanisms for removing H 2 O 2 in Planomicrobium strain AX6. The DEGs identified here could provide a competitive advantage for the existence of Planomicrobium strain AX6 in H 2 O 2 -polluted environments." @default.
• W4308449901 created "2022-11-12" @default.
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• W4308449901 date "2022-11-05" @default.
• W4308449901 modified "2023-10-01" @default.
• W4308449901 title "Transcriptional and biochemical analyses of Planomicrobium strain AX6 from Qinghai-Tibetan Plateau, China, reveal hydrogen peroxide scavenging potential" @default.
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• W4308449901 doi "https://doi.org/10.1186/s12866-022-02677-w" @default.
• W4308449901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36335290" @default.
• W4308449901 hasPublicationYear "2022" @default.
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