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- W4308451198 abstract "ABSTRACT The discovery that DA transients can be mapped onto the reward prediction errors in temporal difference models is a pinnacle achievement of neuroscience. Yet, there is abundant evidence that DA activity reinforces actions, suggesting it serves as an intrinsically rewarding event. These two possibilities are so conceptually intertwined that it is not surprising that they have been so far experimentally conflated. Here, using computational modeling, behavioural blocking and optogenetics, we show that stimulating VTA DA neurons promotes learning even when a natural reward and DA stimulation are held constant across the learning phases of blocking. These findings provide strong evidence in favour of the prediction error hypothesis rather than encoding the rewarding value of appetitive events." @default.
- W4308451198 created "2022-11-12" @default.
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- W4308451198 date "2022-11-06" @default.
- W4308451198 modified "2023-10-18" @default.
- W4308451198 title "Rewarding Value or Prediction Error: Settling the debate over the role of dopamine in reward learning" @default.
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- W4308451198 doi "https://doi.org/10.1101/2022.11.06.515338" @default.
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