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• W4308451851 abstract "This study was conducted to investigate the impacts of chlorogenic acid (CGA) on growth performance, intestinal permeability, intestinal digestion and absorption-related enzyme activities, immune responses, antioxidant capacity and cecum microbial composition in weaned rabbits. One hundred and sixty weaned rabbits were allotted to four treatment groups and fed with a basal diet or a basal diet supplemented with 400, 800, or 1,600 mg/kg CGA, respectively. After a 35-d trial, rabbits on the 800 mg/kg CGA-supplemented group had higher ( p &lt; 0.05) ADG and lower ( p &lt; 0.05) F/G than those in control (CON) group. According to the result of growth performance, eight rabbits per group were randomly selected from the CON group and 800 mg/kg CGA group to collect serum, intestinal tissue samples and cecum chyme samples. Results showed that compared with the CON group, supplementation with 800 mg/kg CGA decreased ( p &lt; 0.05) levels of D-lactate, diamine oxidase, IL-1β, IL-6, and malondialdehyde (MDA), and increased IL-10 concentration in the serum; increased ( p &lt; 0.05) jejunal ratio of villus height to crypt depth, enhanced ( p &lt; 0.05) activities of maltase and sucrase, increased ( p &lt; 0.05) concentrations of IL-10, T-AOC, MHCII and transforming growth factor-α, and decreased ( p &lt; 0.05) levels of TNF-α and MDA in the jejunum of weaned rabbits. In addition, results of high-throughput sequencing showed that CGA supplementation elevated ( p &lt; 0.05) microbial diversity and richness, and increased ( p &lt; 0.05) the abundances of butyrate-producing bacteria (including genera V9D2013_group , Monoglobus , Papillibacter , UCG-005 , and Ruminococcus ). These results indicated that dietary supplementation with 800 mg/kg CGA could improve the growth performance of weaned rabbits by enhancing intestinal structural integrity, improving the intestinal epithelium functions, and modulating the composition and diversity of gut microbiota." @default.
• W4308451851 created "2022-11-12" @default.
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• W4308451851 date "2022-11-07" @default.
• W4308451851 modified "2023-09-30" @default.
• W4308451851 title "Chlorogenic acid improves growth performance of weaned rabbits via modulating the intestinal epithelium functions and intestinal microbiota" @default.
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• W4308451851 doi "https://doi.org/10.3389/fmicb.2022.1027101" @default.
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