Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308455079> ?p ?o ?g. }
- W4308455079 abstract "Abstract The assembly of mammalian SWI/SNF chromatin remodeling complexes is developmentally programed, and loss/mutations of SWI/SNF subunits alter the levels of other components through proteolysis, causing cancers. Here, we show that mouse Lsd1/Kdm1a deletion causes dramatic dissolution of SWI/SNF complexes and that LSD1 demethylates the methylated lysine residues in SMARCC1 and SMARCC2 to preserve the structural integrity of SWI/SNF complexes. The methylated SMARCC1/SMARCC2 are targeted for proteolysis by L3MBTL3 and the CRL4 DCAF5 ubiquitin ligase complex. We identify SMARCC1 as the critical target of LSD1 and L3MBTL3 to maintain the pluripotency and self-renewal of embryonic stem cells. L3MBTL3 also regulates SMARCC1/SMARCC2 proteolysis induced by the loss of SWI/SNF subunits. Consistently, mouse L3mbtl3 deletion causes striking accumulation of SWI/SNF components, associated with embryonic lethality. Our studies reveal that the assembly/disassembly of SWI/SNF complexes is dynamically controlled by a lysine-methylation dependent proteolytic mechanism to maintain the integrity of the SWI/SNF complexes." @default.
- W4308455079 created "2022-11-12" @default.
- W4308455079 creator A5024579806 @default.
- W4308455079 creator A5030084209 @default.
- W4308455079 creator A5032380595 @default.
- W4308455079 creator A5046327468 @default.
- W4308455079 creator A5051681511 @default.
- W4308455079 creator A5055716191 @default.
- W4308455079 creator A5083369904 @default.
- W4308455079 creator A5089517987 @default.
- W4308455079 date "2022-11-05" @default.
- W4308455079 modified "2023-10-15" @default.
- W4308455079 title "The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis" @default.
- W4308455079 cites W1761323037 @default.
- W4308455079 cites W1964813856 @default.
- W4308455079 cites W1965027943 @default.
- W4308455079 cites W1973549360 @default.
- W4308455079 cites W1984249881 @default.
- W4308455079 cites W1987346667 @default.
- W4308455079 cites W1992868516 @default.
- W4308455079 cites W1999463649 @default.
- W4308455079 cites W2006932105 @default.
- W4308455079 cites W2009858080 @default.
- W4308455079 cites W2013127588 @default.
- W4308455079 cites W2014069479 @default.
- W4308455079 cites W2014596538 @default.
- W4308455079 cites W2017308570 @default.
- W4308455079 cites W2021120490 @default.
- W4308455079 cites W2028488121 @default.
- W4308455079 cites W2028835848 @default.
- W4308455079 cites W2028898542 @default.
- W4308455079 cites W2031496441 @default.
- W4308455079 cites W2039033194 @default.
- W4308455079 cites W2040365591 @default.
- W4308455079 cites W2042742511 @default.
- W4308455079 cites W2043624735 @default.
- W4308455079 cites W2054870849 @default.
- W4308455079 cites W2057877925 @default.
- W4308455079 cites W2058223580 @default.
- W4308455079 cites W2062878045 @default.
- W4308455079 cites W2072671967 @default.
- W4308455079 cites W2074974586 @default.
- W4308455079 cites W2075428268 @default.
- W4308455079 cites W2093396457 @default.
- W4308455079 cites W2106578635 @default.
- W4308455079 cites W2107829555 @default.
- W4308455079 cites W2109113060 @default.
- W4308455079 cites W2110588521 @default.
- W4308455079 cites W2112728955 @default.
- W4308455079 cites W2119079421 @default.
- W4308455079 cites W2120594989 @default.
- W4308455079 cites W2131701423 @default.
- W4308455079 cites W2157771031 @default.
- W4308455079 cites W2160649479 @default.
- W4308455079 cites W2162779169 @default.
- W4308455079 cites W2165853153 @default.
- W4308455079 cites W2218949872 @default.
- W4308455079 cites W2406001921 @default.
- W4308455079 cites W2438467628 @default.
- W4308455079 cites W2504181072 @default.
- W4308455079 cites W2551499720 @default.
- W4308455079 cites W2619266720 @default.
- W4308455079 cites W2762828108 @default.
- W4308455079 cites W2785163754 @default.
- W4308455079 cites W2789326366 @default.
- W4308455079 cites W2802116908 @default.
- W4308455079 cites W2895850607 @default.
- W4308455079 cites W2896643719 @default.
- W4308455079 cites W2901744469 @default.
- W4308455079 cites W2969861110 @default.
- W4308455079 cites W3185440378 @default.
- W4308455079 cites W4212766227 @default.
- W4308455079 cites W70698837 @default.
- W4308455079 doi "https://doi.org/10.1038/s41467-022-34348-9" @default.
- W4308455079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36335117" @default.
- W4308455079 hasPublicationYear "2022" @default.
- W4308455079 type Work @default.
- W4308455079 citedByCount "2" @default.
- W4308455079 countsByYear W43084550792023 @default.
- W4308455079 crossrefType "journal-article" @default.
- W4308455079 hasAuthorship W4308455079A5024579806 @default.
- W4308455079 hasAuthorship W4308455079A5030084209 @default.
- W4308455079 hasAuthorship W4308455079A5032380595 @default.
- W4308455079 hasAuthorship W4308455079A5046327468 @default.
- W4308455079 hasAuthorship W4308455079A5051681511 @default.
- W4308455079 hasAuthorship W4308455079A5055716191 @default.
- W4308455079 hasAuthorship W4308455079A5083369904 @default.
- W4308455079 hasAuthorship W4308455079A5089517987 @default.
- W4308455079 hasBestOaLocation W43084550791 @default.
- W4308455079 hasConcept C102658986 @default.
- W4308455079 hasConcept C104317684 @default.
- W4308455079 hasConcept C134459356 @default.
- W4308455079 hasConcept C166941617 @default.
- W4308455079 hasConcept C167227067 @default.
- W4308455079 hasConcept C181199279 @default.
- W4308455079 hasConcept C185592680 @default.
- W4308455079 hasConcept C25602115 @default.
- W4308455079 hasConcept C2776016237 @default.
- W4308455079 hasConcept C2781307694 @default.
- W4308455079 hasConcept C33288867 @default.