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- W4308455799 abstract "Complete comprehension of clinically relevant variation among human genomes is likely only to come from sequencing platforms that are cost-efficient, and which feature both accurate base calling and long-range DNA phasing capability. The NGS revolution has struggled to meet the latter of these needs. Here we describe a protocol to address this limitation by preserving the molecular origin of short sequencing reads with an insignificant increase to sequencing costs. Whole haplotype-resolved genomes with megabase-scale phase blocks can be obtained with this method; offering researchers a unique opportunity to tackle the hurdles of de novo sequencing without being limited by a lack of resources." @default.
- W4308455799 created "2022-11-12" @default.
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- W4308455799 date "2022-11-07" @default.
- W4308455799 modified "2023-09-25" @default.
- W4308455799 title "Low-Cost Genome-Scale Phasing with Barcode-Linked Sequencing" @default.
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- W4308455799 doi "https://doi.org/10.1007/978-1-0716-2819-5_6" @default.
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