Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308456489> ?p ?o ?g. }
- W4308456489 endingPage "6442" @default.
- W4308456489 startingPage "6431" @default.
- W4308456489 abstract "The BvgAS two-component system regulates virulence gene expression in Bordetella pertussis. Although precise three-dimensional structural information is not available for the response regulator BvgA, its sequence conservation with E. coli NarL and previous studies have indicated that it is composed of 3 domains: an N-terminal domain (NTD) containing the phosphorylation site, a linker, and a DNA-binding C-terminal domain (CTD). Previous work has determined how BvgACTD dimers interact with the promoter (PfhaB) of fhaB, the gene encoding the virulence adhesin filamentous hemagglutinin. Here we use molecular modeling, FeBABE footprinting, and crosslinking to show that within the transcription complex of phosphorylated BvgA (BvgA∼P), B. pertussis RNAP, and PfhaB, the NTDs displace from the CTDs and are positioned at specific locations relative to the three BvgA∼P binding sites. Our work identifies a patch of the NTD that faces the DNA and suggests that BvgA∼P undergoes a conformational rearrangement that relocates the NTD to allow productive interaction of the CTD with the DNA." @default.
- W4308456489 created "2022-11-12" @default.
- W4308456489 creator A5002554003 @default.
- W4308456489 creator A5008258237 @default.
- W4308456489 creator A5017046869 @default.
- W4308456489 creator A5018229511 @default.
- W4308456489 creator A5023226235 @default.
- W4308456489 creator A5033112541 @default.
- W4308456489 creator A5046598458 @default.
- W4308456489 creator A5053360118 @default.
- W4308456489 creator A5058454076 @default.
- W4308456489 creator A5059869110 @default.
- W4308456489 creator A5066203374 @default.
- W4308456489 creator A5084965215 @default.
- W4308456489 creator A5091234712 @default.
- W4308456489 date "2022-01-01" @default.
- W4308456489 modified "2023-10-03" @default.
- W4308456489 title "Conformational change of the Bordetella response regulator BvgA accompanies its activation of the B. pertussis virulence gene fhaB" @default.
- W4308456489 cites W1525087137 @default.
- W4308456489 cites W1558516755 @default.
- W4308456489 cites W1566975483 @default.
- W4308456489 cites W1975459052 @default.
- W4308456489 cites W1991159698 @default.
- W4308456489 cites W1991366673 @default.
- W4308456489 cites W2021582328 @default.
- W4308456489 cites W2032102615 @default.
- W4308456489 cites W2032118694 @default.
- W4308456489 cites W2036248591 @default.
- W4308456489 cites W2040442184 @default.
- W4308456489 cites W2040644205 @default.
- W4308456489 cites W2054823707 @default.
- W4308456489 cites W2061868125 @default.
- W4308456489 cites W2063563807 @default.
- W4308456489 cites W2064156035 @default.
- W4308456489 cites W2066562160 @default.
- W4308456489 cites W2066795176 @default.
- W4308456489 cites W2087087669 @default.
- W4308456489 cites W2088933990 @default.
- W4308456489 cites W2089236361 @default.
- W4308456489 cites W2092852201 @default.
- W4308456489 cites W2098193771 @default.
- W4308456489 cites W2100828447 @default.
- W4308456489 cites W2102993309 @default.
- W4308456489 cites W2109211478 @default.
- W4308456489 cites W2116418423 @default.
- W4308456489 cites W2135034797 @default.
- W4308456489 cites W2142600143 @default.
- W4308456489 cites W2145661401 @default.
- W4308456489 cites W2146254376 @default.
- W4308456489 cites W2166133396 @default.
- W4308456489 cites W2166314507 @default.
- W4308456489 cites W2761656312 @default.
- W4308456489 cites W2802374070 @default.
- W4308456489 cites W2922339834 @default.
- W4308456489 cites W3025389188 @default.
- W4308456489 cites W3027361487 @default.
- W4308456489 cites W3177828909 @default.
- W4308456489 cites W3183475563 @default.
- W4308456489 doi "https://doi.org/10.1016/j.csbj.2022.10.042" @default.
- W4308456489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36467586" @default.
- W4308456489 hasPublicationYear "2022" @default.
- W4308456489 type Work @default.
- W4308456489 citedByCount "0" @default.
- W4308456489 crossrefType "journal-article" @default.
- W4308456489 hasAuthorship W4308456489A5002554003 @default.
- W4308456489 hasAuthorship W4308456489A5008258237 @default.
- W4308456489 hasAuthorship W4308456489A5017046869 @default.
- W4308456489 hasAuthorship W4308456489A5018229511 @default.
- W4308456489 hasAuthorship W4308456489A5023226235 @default.
- W4308456489 hasAuthorship W4308456489A5033112541 @default.
- W4308456489 hasAuthorship W4308456489A5046598458 @default.
- W4308456489 hasAuthorship W4308456489A5053360118 @default.
- W4308456489 hasAuthorship W4308456489A5058454076 @default.
- W4308456489 hasAuthorship W4308456489A5059869110 @default.
- W4308456489 hasAuthorship W4308456489A5066203374 @default.
- W4308456489 hasAuthorship W4308456489A5084965215 @default.
- W4308456489 hasAuthorship W4308456489A5091234712 @default.
- W4308456489 hasBestOaLocation W43084564891 @default.
- W4308456489 hasConcept C101762097 @default.
- W4308456489 hasConcept C104317684 @default.
- W4308456489 hasConcept C111919701 @default.
- W4308456489 hasConcept C11960822 @default.
- W4308456489 hasConcept C138223613 @default.
- W4308456489 hasConcept C138885662 @default.
- W4308456489 hasConcept C143065580 @default.
- W4308456489 hasConcept C150194340 @default.
- W4308456489 hasConcept C179926584 @default.
- W4308456489 hasConcept C185592680 @default.
- W4308456489 hasConcept C2777582894 @default.
- W4308456489 hasConcept C2777824465 @default.
- W4308456489 hasConcept C2778021871 @default.
- W4308456489 hasConcept C2780557392 @default.
- W4308456489 hasConcept C2781196521 @default.
- W4308456489 hasConcept C41008148 @default.
- W4308456489 hasConcept C41895202 @default.
- W4308456489 hasConcept C523546767 @default.
- W4308456489 hasConcept C54355233 @default.
- W4308456489 hasConcept C552990157 @default.