Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308458724> ?p ?o ?g. }
- W4308458724 endingPage "8092" @default.
- W4308458724 startingPage "8081" @default.
- W4308458724 abstract "Biomarkers for the acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) are urgently needed to provide better patient management. We aimed to investigate whether serum 1,25(OH)2D3 (1,25-dihydroxy vitamin D3) levels predict AE-IPF and whether they could be a potential prognostic biomarker for IPF.This prospective study included 72 patients with IPF (31 with stable IPF and 41 with AE-IPF). All participants were recruited during hospitalisation at Tianjin Chest Hospital and were followed up for at least 12 months. Demographics, comorbidities, arterial blood gas, and serum biochemical profile, radiological features, and anti-fibrotic therapy were evaluated. Serum concentrations of 1,25(OH)2D3 and transforming growth factor beta1 (TGFβ1) were detected using enzyme-linked immunosorbent assay (ELISA). Risk factors for AE-IPF were identified using multivariate analysis. Prognostic factors were assessed using Kaplan-Meier and Cox regression analyses.Baseline values of alveolar-arterial oxygen difference (A-aDO2) (40.85 mmHg vs 29.2 mmHg, p =0.035), white blood cell counts (10.09 ± 4.2×109/L vs 7.46 ± 7.84×109/L, p <0.001), percentage of monocytes (7.36 ± 1.36% vs 6.6 ± 1.2%, p =0.017), C-reactive protein (CRP) (2.1 mg/dL vs 1.12 mg/dL, p =0.015) and procalcitonin (PCT) (36.59% vs 3.23%, p <0.001) were significantly higher in AE-IPF patients than in stable IPF patients. Instead, the mean concentration of serum calcium and 1,25(OH)2D3 at baseline were higher in IPF patients with stable disease than in those with acute exacerbation (2.17 ± 0.13 nmol/L vs 2.09 ± 0.13 nmol/L, p =0.023 and 16.62 pg/mL vs 11.58 pg/mL, p <0.001, respectively). In multivariate analysis, a higher proportion of patients with lower serum 1,25(OH)2D3 levels experienced AE-IPF (OR 0.884, 95% CI 0.791-0.987, p =0.029), and rising serum PCT level (PCT > 0.05 ng/mL) was associated with an increased risk of mortality (HR 3.664, 95% CI 1.010-12.900, p =0.043).Decreased serum 1,25(OH)2D3 is associated with an increased risk of acute exacerbation for patients with IPF. A high serum PCT level is predictive of worse prognosis in IPF patients. 1,25(OH)2D3 may be a potential biomarker for AE-IPF, while PCT could be a prognostic biomarker for IPF." @default.
- W4308458724 created "2022-11-12" @default.
- W4308458724 creator A5017602252 @default.
- W4308458724 creator A5066180348 @default.
- W4308458724 creator A5080299075 @default.
- W4308458724 date "2022-11-01" @default.
- W4308458724 modified "2023-10-15" @default.
- W4308458724 title "The Role of Serum 1,25-Dihydroxy Vitamin D3 and PCT in Idiopathic Pulmonary Fibrosis" @default.
- W4308458724 cites W1878569558 @default.
- W4308458724 cites W1938547050 @default.
- W4308458724 cites W1950009848 @default.
- W4308458724 cites W1967896418 @default.
- W4308458724 cites W1968353658 @default.
- W4308458724 cites W1978606574 @default.
- W4308458724 cites W1985598521 @default.
- W4308458724 cites W1996480023 @default.
- W4308458724 cites W2002587076 @default.
- W4308458724 cites W2007414618 @default.
- W4308458724 cites W2013155459 @default.
- W4308458724 cites W2031803098 @default.
- W4308458724 cites W2043523970 @default.
- W4308458724 cites W2116521677 @default.
- W4308458724 cites W2117488044 @default.
- W4308458724 cites W2119845256 @default.
- W4308458724 cites W2125553008 @default.
- W4308458724 cites W2141978072 @default.
- W4308458724 cites W2142628255 @default.
- W4308458724 cites W2152246102 @default.
- W4308458724 cites W2153059487 @default.
- W4308458724 cites W2163010779 @default.
- W4308458724 cites W2167189518 @default.
- W4308458724 cites W2167383172 @default.
- W4308458724 cites W2168363420 @default.
- W4308458724 cites W2176921793 @default.
- W4308458724 cites W2417598373 @default.
- W4308458724 cites W2440054067 @default.
- W4308458724 cites W2467259684 @default.
- W4308458724 cites W2533435663 @default.
- W4308458724 cites W2585707392 @default.
- W4308458724 cites W2605520722 @default.
- W4308458724 cites W2615460494 @default.
- W4308458724 cites W2621470802 @default.
- W4308458724 cites W2738601401 @default.
- W4308458724 cites W2753866383 @default.
- W4308458724 cites W2756020545 @default.
- W4308458724 cites W2770778260 @default.
- W4308458724 cites W2795135157 @default.
- W4308458724 cites W2810579324 @default.
- W4308458724 cites W2889197569 @default.
- W4308458724 cites W2902697612 @default.
- W4308458724 cites W2906990747 @default.
- W4308458724 cites W2909263085 @default.
- W4308458724 cites W2929609469 @default.
- W4308458724 cites W2972509123 @default.
- W4308458724 cites W2995067265 @default.
- W4308458724 cites W3011457746 @default.
- W4308458724 cites W3046660532 @default.
- W4308458724 cites W3119948841 @default.
- W4308458724 cites W3212155451 @default.
- W4308458724 cites W4205328813 @default.
- W4308458724 cites W4221114558 @default.
- W4308458724 cites W4225403198 @default.
- W4308458724 cites W4286489041 @default.
- W4308458724 cites W4292686124 @default.
- W4308458724 doi "https://doi.org/10.2147/ijgm.s386984" @default.
- W4308458724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36389018" @default.
- W4308458724 hasPublicationYear "2022" @default.
- W4308458724 type Work @default.
- W4308458724 citedByCount "1" @default.
- W4308458724 countsByYear W43084587242023 @default.
- W4308458724 crossrefType "journal-article" @default.
- W4308458724 hasAuthorship W4308458724A5017602252 @default.
- W4308458724 hasAuthorship W4308458724A5066180348 @default.
- W4308458724 hasAuthorship W4308458724A5080299075 @default.
- W4308458724 hasBestOaLocation W43084587241 @default.
- W4308458724 hasConcept C10936531 @default.
- W4308458724 hasConcept C124490489 @default.
- W4308458724 hasConcept C126322002 @default.
- W4308458724 hasConcept C185592680 @default.
- W4308458724 hasConcept C188816634 @default.
- W4308458724 hasConcept C2777014857 @default.
- W4308458724 hasConcept C2777714996 @default.
- W4308458724 hasConcept C2778341716 @default.
- W4308458724 hasConcept C2778384902 @default.
- W4308458724 hasConcept C2778488018 @default.
- W4308458724 hasConcept C2781197716 @default.
- W4308458724 hasConcept C55493867 @default.
- W4308458724 hasConcept C71924100 @default.
- W4308458724 hasConcept C90924648 @default.
- W4308458724 hasConceptScore W4308458724C10936531 @default.
- W4308458724 hasConceptScore W4308458724C124490489 @default.
- W4308458724 hasConceptScore W4308458724C126322002 @default.
- W4308458724 hasConceptScore W4308458724C185592680 @default.
- W4308458724 hasConceptScore W4308458724C188816634 @default.
- W4308458724 hasConceptScore W4308458724C2777014857 @default.
- W4308458724 hasConceptScore W4308458724C2777714996 @default.
- W4308458724 hasConceptScore W4308458724C2778341716 @default.
- W4308458724 hasConceptScore W4308458724C2778384902 @default.