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- W4308459044 abstract "An important window of opportunity for early-life exposures has been proposed for the development of atopic eczema and asthma.However, it is unknown whether hay fever with a peak incidence around late school age to adolescence is similarly determined very early in life.In the Protection against Allergy-Study in Rural Environments (PASTURE) birth cohort potentially relevant exposures such as farm milk consumption and exposure to animal sheds were assessed at multiple time points from infancy to age 10.5 years and classified by repeated measure latent class analyses (n = 769). Fecal samples at ages 2 and 12 months were sequenced by 16S rRNA. Hay fever was defined by parent-reported symptoms and/or physician's diagnosis of hay fever in the last 12 months using questionnaires at 10.5 years.Farm children had half the risk of hay fever at 10.5 years (adjusted odds ratio [aOR] 0.50; 95% CI 0.31-0.79) than that of nonfarm children. Whereas early life events such as gut microbiome richness at 12 months (aOR 0.66; 95% CI 0.46-0.96) and exposure to animal sheds in the first 3 years of life (aOR 0.26; 95% CI 0.06-1.15) were determinants of hay fever, the continuous consumption of farm milk from infancy up to school age was necessary to exert the protective effect (aOR 0.35; 95% CI 0.17-0.72).While early life events determine the risk of subsequent hay fever, continuous exposure is necessary to achieve protection. These findings argue against the notion that only early life exposures set long-lasting trajectories." @default.
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- W4308459044 date "2023-02-01" @default.
- W4308459044 modified "2023-10-09" @default.
- W4308459044 title "Continuous Rather Than Solely Early Farm Exposure Protects From Hay Fever Development" @default.
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- W4308459044 doi "https://doi.org/10.1016/j.jaip.2022.10.035" @default.
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