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- W4308462370 abstract "ABSTRACT Respiratory epithelial cells line the airways and represent the first line of defense against respiratory pathogens. The cellular heterogeneity of the airway wall has only recently been recognized by single-cell analyses. Here, we leveraged single-cell RNA sequencing of primary human bronchial epithelial cells growing in air-liquid interface to determine cell-specific changes evoked by flagellin, a protein driving the motility of many mucosal pathogens. We detected seven cell clusters in the human epithelium, including ciliated cells, ionocytes and several states of basal and secretory cells, of which only inflammatory basal cells and inflammatory secretory cells showed a proportional increase in response to flagellin. Only inflammatory secretory cells showed evidence of metabolic reprogramming toward aerobic glycolysis, and inhibition of the mTOR pathway specifically reduced this subset, prevented this metabolic shift, and reduced inflammatory gene transcription in these cells. This study expands our knowledge of the airway’s immune response to flagellated pathogens to single cell resolution and defines a novel target to modulate mucosal immunity during bacterial infections." @default.
- W4308462370 created "2022-11-12" @default.
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- W4308462370 date "2022-11-03" @default.
- W4308462370 modified "2023-10-18" @default.
- W4308462370 title "Single-cell transcriptomics reveals subset-specific metabolic profiles underpinning the bronchial epithelial response to flagellin" @default.
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- W4308462370 doi "https://doi.org/10.1101/2022.11.02.514918" @default.
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