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- W4308463075 endingPage "103944" @default.
- W4308463075 startingPage "103944" @default.
- W4308463075 abstract "Chemo/radiotherapy-induced oral mucositis (OM) has painful ulcers that can impair patients' lives. This study aimed to develop and characterize ( in vitro and in vivo ) benzydamine (BNZ) freeze-dried mucoadhesive wafers from chitosan (CS) in combination with different hydrophilic polymers as a locally controlled delivery system for OM treatment. The porous (69–83%) wafers (0.02–0.1 g and 3.0–5.9 mm) released 80–94% of their drug content over 8 h and demonstrated 40–53 g mucoadhesion strength. Mechanical evaluations of F1 (CS) and F14 (CS/HPMC (3:1)) selected formulations showed modulus of elasticity, tensile strength, and % elongation at break ranging from 0.2 to 0.3 MPa, 0.01–0.02 MPa, and 15–18%, respectively. The antimicrobial efficacy of BNZ-loaded wafers was significantly higher than drug-free ones. The extract solutions of the drug-free and BNZ-loaded wafers revealed 100 and 20% viability in human gingival fibroblasts (HGFs) exposure. In vivo analysis demonstrated that BNZ-loaded wafers represented a significant reduction in macroscopic evaluation of OM and histopathological tests compared to positive and negative controls and drug-free wafers. Conclusively, lyophilized F1 and F14 mucoadhesive wafers had acceptable structural, mechanical, and biological properties and might be promising drug delivery systems for OM." @default.
- W4308463075 created "2022-11-12" @default.
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- W4308463075 date "2022-12-01" @default.
- W4308463075 modified "2023-10-16" @default.
- W4308463075 title "Preparation and characterization of benzydamine hydrochloride-loaded lyophilized mucoadhesive wafers for the treatment of oral mucositis" @default.
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- W4308463075 doi "https://doi.org/10.1016/j.jddst.2022.103944" @default.
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