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- W4308464597 abstract "Abstract Animals must adapt their dietary choices to meet their nutritional needs. How these needs are detected and translated into nutrient-specific appetites that drive food-choice behaviours is poorly understood. Here we show that enteroendocrine cells of the adult female Drosophila midgut sense nutrients and in response release neuropeptide F (NPF), which is an ortholog of mammalian neuropeptide Y-family gut-brain hormones. Gut-derived NPF acts on glucagon-like adipokinetic hormone (AKH) signalling to induce sugar satiety and increase consumption of protein-rich food, and on adipose tissue to promote storage of ingested nutrients. Suppression of NPF-mediated gut signalling leads to overconsumption of dietary sugar while simultaneously decreasing intake of protein-rich yeast. Furthermore, gut-derived NPF has a female-specific function in promoting consumption of protein-containing food in mated females. Together, our findings suggest that gut NPF-to-AKH signalling modulates specific appetites and regulates food choice to ensure homeostatic consumption of nutrients, providing insight into the hormonal mechanisms that underlie nutrient-specific hungers." @default.
- W4308464597 created "2022-11-12" @default.
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- W4308464597 date "2022-11-07" @default.
- W4308464597 modified "2023-10-16" @default.
- W4308464597 title "A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila" @default.
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- W4308464597 doi "https://doi.org/10.1038/s42255-022-00672-z" @default.
- W4308464597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36344765" @default.
- W4308464597 hasPublicationYear "2022" @default.
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