Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308474090> ?p ?o ?g. }
- W4308474090 abstract "ABSTRACT Rho GTPases, among them Rac1 and Rac3, are major transducers of extracellular signals and are involved in multiple cellular processes. In cortical interneurons, the neurons that control excitation/inhibition balance of cortical circuits, Rac1 and Rac3 are essential for their development. Ablation of both, leads to a severe reduction in the numbers of mature interneurons found in the murine cortex, which is partially due to abnormal cell cycle progression of interneuron precursors and defective formation of their growth cones. Here we present new evidence that upon Rac1 and Rac3 ablation, centrosome, Golgi complex and lysosome positioning are significantly perturbed, thus affecting both interneuron migration and axon growth. Moreover, for the first time we provide evidence of altered expression and localization of the two-pore channel 2 (TPC2) voltage-gated ion channel that mediates Ca 2+ release. Pharmacological inhibition of TPC2 negatively affected axonal growth and migration of interneurons. Our data taken together suggest that TPC2 contributes to the severe phenotype in axon growth initiation, extension and interneuron migration in the absence of Rac1 and Rac3. SUMMARY STATEMENT Rac1/3 severely affect cortical interneuron migration by affecting centrosome, Golgi and lysosome positioning. TPC2 likely contributes to the phenotype by decreasing axonogenesis and somatic migration." @default.
- W4308474090 created "2022-11-12" @default.
- W4308474090 creator A5031138287 @default.
- W4308474090 creator A5044129721 @default.
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- W4308474090 creator A5069467635 @default.
- W4308474090 creator A5074120996 @default.
- W4308474090 creator A5078101586 @default.
- W4308474090 date "2022-11-07" @default.
- W4308474090 modified "2023-10-17" @default.
- W4308474090 title "Rac1, Rac3 GTPases and TPC2 are required for axonal outgrowth and migration of cortical interneurons" @default.
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