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• W4308483649 abstract "Abstract Sleep abnormalities are prevalent in Alzheimer’s disease, with sleep quality already impaired at its preclinical stage. Epidemiological and experimental data point to sleep abnormalities contributing to the risk of Alzheimer’s disease. However, previous studies are limited by either a lack of Alzheimer’s disease biomarkers, reduced sample size or cross-sectional design. Understanding if, when, and how poor sleep contributes to Alzheimer’s disease progression is important so that therapies can be targeted to the right phase of the disease. Using the largest cohort to date, the European Prevention of Alzheimer’s Dementia Longitudinal Cohort Study, we test the hypotheses that poor sleep is associated with core Alzheimer’s disease CSF biomarkers cross-sectionally and predicts future increments of Alzheimer’s disease pathology in people without identifiable symptoms of Alzheimer’s disease at baseline. This study included 1168 adults aged over 50 years with CSF core Alzheimer’s disease biomarkers (total tau, phosphorylated tau and amyloid-beta), cognitive performance, and sleep quality (Pittsburgh sleep quality index questionnaire) data. We used multivariate linear regressions to analyse associations between core Alzheimer’s disease biomarkers and the following Pittsburgh sleep quality index measures: total score of sleep quality, binarized score (poor sleep categorized as Pittsburgh sleep quality index &gt; 5), sleep latency, duration, efficiency and disturbance. On a subsample of 332 participants with CSF taken at baseline and after an average period of 1.5 years, we assessed the effect of baseline sleep quality on change in Alzheimer’s disease biomarkers over time. Cross-sectional analyses revealed that poor sleep quality (Pittsburgh sleep quality index total &gt; 5) was significantly associated with higher CSF t-tau; shorter sleep duration (&lt;7 h) was associated with higher CSF p-tau and t-tau; and a higher degree of sleep disturbance (1–9 versus 0 and &gt;9 versus 0) was associated with lower CSF amyloid-beta. Longitudinal analyses showed that greater sleep disturbances (1–9 versus 0 and &gt;9 versus 0) were associated with a decrease in CSF Aβ42 over time. This study demonstrates that self-reported poor sleep quality is associated with greater Alzheimer’s disease-related pathology in cognitively unimpaired individuals, with longitudinal results further strengthening the hypothesis that disrupted sleep may represent a risk factor for Alzheimer’s disease. This highlights the need for future work to test the efficacy of preventive practices, designed to improve sleep at pre-symptomatic stages of disease, on reducing Alzheimer’s disease pathology." @default.
• W4308483649 created "2022-11-12" @default.
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• W4308483649 date "2022-11-02" @default.
• W4308483649 modified "2023-10-16" @default.
• W4308483649 title "Cross-sectional and longitudinal association of sleep and Alzheimer biomarkers in cognitively unimpaired adults" @default.
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• W4308483649 cites W1847168837 @default.
• W4308483649 cites W1966657660 @default.
• W4308483649 cites W1971351343 @default.
• W4308483649 cites W1972194501 @default.
• W4308483649 cites W1983620103 @default.
• W4308483649 cites W1986894866 @default.
• W4308483649 cites W1991952617 @default.
• W4308483649 cites W1999009790 @default.
• W4308483649 cites W2007092083 @default.
• W4308483649 cites W2008854521 @default.
• W4308483649 cites W2013333500 @default.
• W4308483649 cites W2015603515 @default.
• W4308483649 cites W2028623620 @default.
• W4308483649 cites W2042683896 @default.
• W4308483649 cites W2043909860 @default.
• W4308483649 cites W2045985094 @default.
• W4308483649 cites W2047101604 @default.
• W4308483649 cites W2058161128 @default.
• W4308483649 cites W2060140214 @default.
• W4308483649 cites W2069440543 @default.
• W4308483649 cites W2080997748 @default.
• W4308483649 cites W2084464534 @default.
• W4308483649 cites W2094785614 @default.
• W4308483649 cites W2110019208 @default.
• W4308483649 cites W2112519660 @default.
• W4308483649 cites W2121766792 @default.
• W4308483649 cites W2128964866 @default.
• W4308483649 cites W2129379145 @default.
• W4308483649 cites W2134157741 @default.
• W4308483649 cites W2134961207 @default.
• W4308483649 cites W2136922708 @default.
• W4308483649 cites W2143790126 @default.
• W4308483649 cites W2148080316 @default.
• W4308483649 cites W2151487996 @default.
• W4308483649 cites W2160311930 @default.
• W4308483649 cites W2161737267 @default.
• W4308483649 cites W2167183660 @default.
• W4308483649 cites W2167311298 @default.
• W4308483649 cites W2167840686 @default.
• W4308483649 cites W2207877462 @default.
• W4308483649 cites W2209808747 @default.
• W4308483649 cites W2323344600 @default.
• W4308483649 cites W2346722537 @default.
• W4308483649 cites W2400677330 @default.
• W4308483649 cites W2440154114 @default.
• W4308483649 cites W2518174992 @default.
• W4308483649 cites W2579960265 @default.
• W4308483649 cites W2611704743 @default.
• W4308483649 cites W2730282614 @default.
• W4308483649 cites W2735226312 @default.
• W4308483649 cites W2739291804 @default.
• W4308483649 cites W2767862404 @default.
• W4308483649 cites W2772468670 @default.
• W4308483649 cites W2773346142 @default.
• W4308483649 cites W2792305910 @default.
• W4308483649 cites W2797347068 @default.
• W4308483649 cites W2892024211 @default.
• W4308483649 cites W2907259654 @default.
• W4308483649 cites W2910774779 @default.
• W4308483649 cites W2912003143 @default.
• W4308483649 cites W2915905384 @default.
• W4308483649 cites W2945475774 @default.
• W4308483649 cites W2952624918 @default.
• W4308483649 cites W2998945366 @default.
• W4308483649 cites W3012183294 @default.
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• W4308483649 cites W3045713553 @default.
• W4308483649 cites W3082048301 @default.
• W4308483649 cites W3082341480 @default.
• W4308483649 cites W3149220138 @default.
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• W4308483649 doi "https://doi.org/10.1093/braincomms/fcac257" @default.
• W4308483649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36337343" @default.
• W4308483649 hasPublicationYear "2022" @default.
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