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- W4308484225 abstract "Most of the patients with gallbladder cancer (GBC), intrahepatic cholangiocarcinoma (iCCA), and peri-hilar cholangiocarcinoma (pCCA) present with advanced disease. Complete staging with multiphasic liver imaging is essential to determine the extent of disease. Operative goals should include a margin-negative resection, portal lymphadenectomy for staging, and sufficient remnant liver volume. Biliary tract malignancies have distinct mutational drivers (GBC and pCCA = ERBB2 in 20%; iCCA = fibroblast growth factor receptor 2 or isocitrate dehydrogenase 1 in 20%) amenable to therapy with inhibitors. Clinical trials assessing neoadjuvant, peri-operative, and adjuvant treatments continue to evolve and now include targeted inhibitors and the integration of hepatic arterial infusion." @default.
- W4308484225 created "2022-11-12" @default.
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- W4308484225 creator A5034255041 @default.
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- W4308484225 date "2023-01-01" @default.
- W4308484225 modified "2023-09-27" @default.
- W4308484225 title "Past, Present, and Future Management of Localized Biliary Tract Malignancies" @default.
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- W4308484225 doi "https://doi.org/10.1016/j.soc.2022.07.007" @default.
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