Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308484806> ?p ?o ?g. }
- W4308484806 endingPage "14139" @default.
- W4308484806 startingPage "14130" @default.
- W4308484806 abstract "Enantioselective methylation is a challenging task in organic chemistry, yet often desirable in drug discovery and optimization. S-Adenosyl methionine (SAM)-dependent methyltransferases (MTases) offer a selective alternative to chemical synthesis and an abundance of potential scaffolds. The crystal structure of C3-indole MTase PsmD from Streptomyces griseofuscus, involved in the biosynthesis of the acetylcholinesterase inhibitor physostigmine, was determined via X-ray crystallography. The amino acid residues essential for catalysis were identified by site-directed mutagenesis, and a mechanism of action was proposed. Furthermore, a PsmD ortholog was identified and characterized. The variant catalyzed enantioselective C-methylation over a broad substrate scope while displaying increased stability. Using this enzyme, preparative-scale enzymatic methylation was performed in cell-free extracts in combination with an SAM recycling system, eliminating the need for cofactor supplementation." @default.
- W4308484806 created "2022-11-12" @default.
- W4308484806 creator A5025754018 @default.
- W4308484806 creator A5040957504 @default.
- W4308484806 creator A5041898009 @default.
- W4308484806 creator A5050957002 @default.
- W4308484806 creator A5063949219 @default.
- W4308484806 creator A5073068817 @default.
- W4308484806 creator A5077629179 @default.
- W4308484806 creator A5090548096 @default.
- W4308484806 date "2022-11-03" @default.
- W4308484806 modified "2023-10-14" @default.
- W4308484806 title "Enzymatic C3-Methylation of Indoles Using Methyltransferase PsmD─Crystal Structure, Catalytic Mechanism, and Preparative Applications" @default.
- W4308484806 cites W1711482514 @default.
- W4308484806 cites W1863525853 @default.
- W4308484806 cites W1965585392 @default.
- W4308484806 cites W1972433022 @default.
- W4308484806 cites W1977939709 @default.
- W4308484806 cites W1979820134 @default.
- W4308484806 cites W1979936807 @default.
- W4308484806 cites W1988967696 @default.
- W4308484806 cites W2017835415 @default.
- W4308484806 cites W2019442169 @default.
- W4308484806 cites W2023257048 @default.
- W4308484806 cites W2027265711 @default.
- W4308484806 cites W2031502544 @default.
- W4308484806 cites W2035503835 @default.
- W4308484806 cites W2045650030 @default.
- W4308484806 cites W2053154832 @default.
- W4308484806 cites W2061523668 @default.
- W4308484806 cites W2066355689 @default.
- W4308484806 cites W2072357277 @default.
- W4308484806 cites W2078686890 @default.
- W4308484806 cites W2088253893 @default.
- W4308484806 cites W2097472327 @default.
- W4308484806 cites W2100071542 @default.
- W4308484806 cites W2117892897 @default.
- W4308484806 cites W2120710370 @default.
- W4308484806 cites W2136391678 @default.
- W4308484806 cites W2295289688 @default.
- W4308484806 cites W2295557285 @default.
- W4308484806 cites W2314067773 @default.
- W4308484806 cites W2340833294 @default.
- W4308484806 cites W2587713724 @default.
- W4308484806 cites W2592790247 @default.
- W4308484806 cites W2764020067 @default.
- W4308484806 cites W2951057335 @default.
- W4308484806 cites W2952291569 @default.
- W4308484806 cites W2956691438 @default.
- W4308484806 cites W2967369717 @default.
- W4308484806 cites W3037307581 @default.
- W4308484806 cites W3096959837 @default.
- W4308484806 cites W3127454123 @default.
- W4308484806 cites W3134425407 @default.
- W4308484806 cites W3156236635 @default.
- W4308484806 cites W3195183144 @default.
- W4308484806 doi "https://doi.org/10.1021/acscatal.2c04240" @default.
- W4308484806 hasPublicationYear "2022" @default.
- W4308484806 type Work @default.
- W4308484806 citedByCount "0" @default.
- W4308484806 crossrefType "journal-article" @default.
- W4308484806 hasAuthorship W4308484806A5025754018 @default.
- W4308484806 hasAuthorship W4308484806A5040957504 @default.
- W4308484806 hasAuthorship W4308484806A5041898009 @default.
- W4308484806 hasAuthorship W4308484806A5050957002 @default.
- W4308484806 hasAuthorship W4308484806A5063949219 @default.
- W4308484806 hasAuthorship W4308484806A5073068817 @default.
- W4308484806 hasAuthorship W4308484806A5077629179 @default.
- W4308484806 hasAuthorship W4308484806A5090548096 @default.
- W4308484806 hasConcept C104317684 @default.
- W4308484806 hasConcept C146686406 @default.
- W4308484806 hasConcept C161790260 @default.
- W4308484806 hasConcept C16318435 @default.
- W4308484806 hasConcept C181199279 @default.
- W4308484806 hasConcept C185592680 @default.
- W4308484806 hasConcept C18903297 @default.
- W4308484806 hasConcept C192527728 @default.
- W4308484806 hasConcept C21951064 @default.
- W4308484806 hasConcept C2776376580 @default.
- W4308484806 hasConcept C2777289219 @default.
- W4308484806 hasConcept C33288867 @default.
- W4308484806 hasConcept C41183919 @default.
- W4308484806 hasConcept C501734568 @default.
- W4308484806 hasConcept C552990157 @default.
- W4308484806 hasConcept C55493867 @default.
- W4308484806 hasConcept C69118441 @default.
- W4308484806 hasConcept C71240020 @default.
- W4308484806 hasConcept C86803240 @default.
- W4308484806 hasConcept C91965660 @default.
- W4308484806 hasConceptScore W4308484806C104317684 @default.
- W4308484806 hasConceptScore W4308484806C146686406 @default.
- W4308484806 hasConceptScore W4308484806C161790260 @default.
- W4308484806 hasConceptScore W4308484806C16318435 @default.
- W4308484806 hasConceptScore W4308484806C181199279 @default.
- W4308484806 hasConceptScore W4308484806C185592680 @default.
- W4308484806 hasConceptScore W4308484806C18903297 @default.
- W4308484806 hasConceptScore W4308484806C192527728 @default.
- W4308484806 hasConceptScore W4308484806C21951064 @default.