FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308485018> ?p ?o ?g. }

• W4308485018 endingPage "119716" @default.
• W4308485018 startingPage "119716" @default.
• W4308485018 abstract "Psilocin, the neuroactive metabolite of psilocybin, is a serotonergic psychedelic that induces an acute altered state of consciousness, evokes lasting changes in mood and personality in healthy individuals, and has potential as an antidepressant treatment. Examining the acute effects of psilocin on resting-state time-varying functional connectivity implicates network-level connectivity motifs that may underlie acute and lasting behavioral and clinical effects. Evaluate the association between resting-state time-varying functional connectivity (tvFC) characteristics and plasma psilocin level (PPL) and subjective drug intensity (SDI) before and right after intake of a psychedelic dose of psilocybin in healthy humans. Fifteen healthy individuals completed the study. Before and at multiple time points after psilocybin intake, we acquired 10-minute resting-state blood-oxygen-level-dependent functional magnetic resonance imaging scans. Leading Eigenvector Dynamics Analysis (LEiDA) and diametrical clustering were applied to estimate discrete, sequentially active brain states. We evaluated associations between the fractional occurrence of brain states during a scan session and PPL and SDI using linear mixed-effects models. We examined associations between brain state dwell time and PPL and SDI using frailty Cox proportional hazards survival analysis. Fractional occurrences for two brain states characterized by lateral frontoparietal and medial fronto-parietal-cingulate coherence were statistically significantly negatively associated with PPL and SDI. Dwell time for these brain states was negatively associated with SDI and, to a lesser extent, PPL. Conversely, fractional occurrence and dwell time of a fully connected brain state partly associated with motion was positively associated with PPL and SDI. Our findings suggest that the acute perceptual psychedelic effects induced by psilocybin may stem from drug-level associated decreases in the occurrence and duration of lateral and medial frontoparietal connectivity motifs. We apply and argue for a modified approach to modeling eigenvectors produced by LEiDA that more fully acknowledges their underlying structure. Together these findings contribute to a more comprehensive neurobiological framework underlying acute effects of serotonergic psychedelics." @default.
• W4308485018 created "2022-11-12" @default.
• W4308485018 creator A5000203733 @default.
• W4308485018 creator A5003592652 @default.
• W4308485018 creator A5004791170 @default.
• W4308485018 creator A5021085020 @default.
• W4308485018 creator A5021739634 @default.
• W4308485018 creator A5030345952 @default.
• W4308485018 creator A5059840085 @default.
• W4308485018 creator A5072918915 @default.
• W4308485018 creator A5077821758 @default.
• W4308485018 creator A5086179765 @default.
• W4308485018 date "2022-12-01" @default.
• W4308485018 modified "2023-10-01" @default.
• W4308485018 title "Psilocybin modulation of time-varying functional connectivity is associated with plasma psilocin and subjective effects" @default.
• W4308485018 cites W1727659491 @default.
• W4308485018 cites W1983183519 @default.
• W4308485018 cites W1998622797 @default.
• W4308485018 cites W2003148418 @default.
• W4308485018 cites W2005821483 @default.
• W4308485018 cites W2015952588 @default.
• W4308485018 cites W2020125737 @default.
• W4308485018 cites W2026832357 @default.
• W4308485018 cites W2033134445 @default.
• W4308485018 cites W2056124784 @default.
• W4308485018 cites W2058046532 @default.
• W4308485018 cites W2070216603 @default.
• W4308485018 cites W2096626991 @default.
• W4308485018 cites W2100268885 @default.
• W4308485018 cites W2118739111 @default.
• W4308485018 cites W2121441663 @default.
• W4308485018 cites W2130010412 @default.
• W4308485018 cites W2150280237 @default.
• W4308485018 cites W2170596036 @default.
• W4308485018 cites W2227520796 @default.
• W4308485018 cites W2536956629 @default.
• W4308485018 cites W2563279629 @default.
• W4308485018 cites W2726287250 @default.
• W4308485018 cites W2767530231 @default.
• W4308485018 cites W2807534705 @default.
• W4308485018 cites W2911514809 @default.
• W4308485018 cites W2914255920 @default.
• W4308485018 cites W2921919805 @default.
• W4308485018 cites W2945506353 @default.
• W4308485018 cites W2945514479 @default.
• W4308485018 cites W2995313551 @default.
• W4308485018 cites W2999279320 @default.
• W4308485018 cites W3005441929 @default.
• W4308485018 cites W3009076589 @default.
• W4308485018 cites W3009551911 @default.
• W4308485018 cites W3015902292 @default.
• W4308485018 cites W3016831942 @default.
• W4308485018 cites W3027590463 @default.
• W4308485018 cites W3029659763 @default.
• W4308485018 cites W3083216124 @default.
• W4308485018 cites W3085641834 @default.
• W4308485018 cites W3091936754 @default.
• W4308485018 cites W3096208965 @default.
• W4308485018 cites W3105240299 @default.
• W4308485018 cites W3110820786 @default.
• W4308485018 cites W3113337956 @default.
• W4308485018 cites W3115450428 @default.
• W4308485018 cites W3156937150 @default.
• W4308485018 cites W3161535964 @default.
• W4308485018 cites W3179473685 @default.
• W4308485018 cites W3213458191 @default.
• W4308485018 cites W4225528034 @default.
• W4308485018 cites W4280648670 @default.
• W4308485018 cites W4292937262 @default.
• W4308485018 doi "https://doi.org/10.1016/j.neuroimage.2022.119716" @default.
• W4308485018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36341951" @default.
• W4308485018 hasPublicationYear "2022" @default.
• W4308485018 type Work @default.
• W4308485018 citedByCount "8" @default.
• W4308485018 countsByYear W43084850182022 @default.
• W4308485018 countsByYear W43084850182023 @default.
• W4308485018 crossrefType "journal-article" @default.
• W4308485018 hasAuthorship W4308485018A5000203733 @default.
• W4308485018 hasAuthorship W4308485018A5003592652 @default.
• W4308485018 hasAuthorship W4308485018A5004791170 @default.
• W4308485018 hasAuthorship W4308485018A5021085020 @default.
• W4308485018 hasAuthorship W4308485018A5021739634 @default.
• W4308485018 hasAuthorship W4308485018A5030345952 @default.
• W4308485018 hasAuthorship W4308485018A5059840085 @default.
• W4308485018 hasAuthorship W4308485018A5072918915 @default.
• W4308485018 hasAuthorship W4308485018A5077821758 @default.
• W4308485018 hasAuthorship W4308485018A5086179765 @default.
• W4308485018 hasBestOaLocation W43084850181 @default.
• W4308485018 hasConcept C118552586 @default.
• W4308485018 hasConcept C124315065 @default.
• W4308485018 hasConcept C126322002 @default.
• W4308485018 hasConcept C141516989 @default.
• W4308485018 hasConcept C15744967 @default.
• W4308485018 hasConcept C169760540 @default.
• W4308485018 hasConcept C170493617 @default.
• W4308485018 hasConcept C2775864247 @default.
• W4308485018 hasConcept C2776502132 @default.
• W4308485018 hasConcept C2779226451 @default.

• next