Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308485570> ?p ?o ?g. }
- W4308485570 abstract "The plasma multimeric glycoprotein von Willebrand factor (VWF) plays a critical role in primary hemostasis by tethering platelets to exposed collagen at sites of vascular injury. Recent studies have identified additional biological roles for VWF, and in particular suggest that VWF may play an important role in regulating inflammatory responses. However, the molecular mechanisms through which VWF exerts its immuno-modulatory effects remain poorly understood. In this study, we report that VWF binding to macrophages triggers downstream MAP kinase signaling, NF-κB activation and production of pro-inflammatory cytokines and chemokines. In addition, VWF binding also drives macrophage M1 polarization and shifts macrophage metabolism towards glycolysis in a p38-dependent manner. Cumulatively, our findings define an important biological role for VWF in modulating macrophage function, and thereby establish a novel link between primary hemostasis and innate immunity." @default.
- W4308485570 created "2022-11-12" @default.
- W4308485570 creator A5003275100 @default.
- W4308485570 creator A5003377656 @default.
- W4308485570 creator A5005209379 @default.
- W4308485570 creator A5007517961 @default.
- W4308485570 creator A5010495294 @default.
- W4308485570 creator A5016706498 @default.
- W4308485570 creator A5017704500 @default.
- W4308485570 creator A5019694324 @default.
- W4308485570 creator A5034913336 @default.
- W4308485570 creator A5041265720 @default.
- W4308485570 creator A5041679272 @default.
- W4308485570 creator A5043670699 @default.
- W4308485570 creator A5044567379 @default.
- W4308485570 creator A5045560783 @default.
- W4308485570 creator A5048862452 @default.
- W4308485570 creator A5051842760 @default.
- W4308485570 creator A5055330906 @default.
- W4308485570 creator A5064256529 @default.
- W4308485570 creator A5072565243 @default.
- W4308485570 creator A5075933920 @default.
- W4308485570 creator A5076098159 @default.
- W4308485570 creator A5084545467 @default.
- W4308485570 creator A5086495162 @default.
- W4308485570 date "2022-11-03" @default.
- W4308485570 modified "2023-10-15" @default.
- W4308485570 title "von Willebrand factor links primary hemostasis to innate immunity" @default.
- W4308485570 cites W1500553660 @default.
- W4308485570 cites W1618588028 @default.
- W4308485570 cites W1914408923 @default.
- W4308485570 cites W1963494914 @default.
- W4308485570 cites W196395934 @default.
- W4308485570 cites W1970055715 @default.
- W4308485570 cites W1974495821 @default.
- W4308485570 cites W1975312317 @default.
- W4308485570 cites W1977039417 @default.
- W4308485570 cites W1978901235 @default.
- W4308485570 cites W1979838917 @default.
- W4308485570 cites W1983817878 @default.
- W4308485570 cites W1987956579 @default.
- W4308485570 cites W1988212011 @default.
- W4308485570 cites W1989528047 @default.
- W4308485570 cites W1993862762 @default.
- W4308485570 cites W1995809132 @default.
- W4308485570 cites W2002822439 @default.
- W4308485570 cites W2003748778 @default.
- W4308485570 cites W2007681709 @default.
- W4308485570 cites W2012718436 @default.
- W4308485570 cites W2017289138 @default.
- W4308485570 cites W2020357852 @default.
- W4308485570 cites W2025396032 @default.
- W4308485570 cites W2028817196 @default.
- W4308485570 cites W2029725077 @default.
- W4308485570 cites W2029998262 @default.
- W4308485570 cites W2050370340 @default.
- W4308485570 cites W2060033555 @default.
- W4308485570 cites W2064031064 @default.
- W4308485570 cites W2065657978 @default.
- W4308485570 cites W2066589515 @default.
- W4308485570 cites W2073425582 @default.
- W4308485570 cites W2089532303 @default.
- W4308485570 cites W2093257146 @default.
- W4308485570 cites W2103205445 @default.
- W4308485570 cites W2118277673 @default.
- W4308485570 cites W2140388107 @default.
- W4308485570 cites W2140481710 @default.
- W4308485570 cites W2146160831 @default.
- W4308485570 cites W2153586956 @default.
- W4308485570 cites W2153846543 @default.
- W4308485570 cites W2163953596 @default.
- W4308485570 cites W2165343718 @default.
- W4308485570 cites W2169456326 @default.
- W4308485570 cites W2177897268 @default.
- W4308485570 cites W2179438025 @default.
- W4308485570 cites W2265978074 @default.
- W4308485570 cites W2279643025 @default.
- W4308485570 cites W2296002833 @default.
- W4308485570 cites W2376553420 @default.
- W4308485570 cites W2395255728 @default.
- W4308485570 cites W2408879765 @default.
- W4308485570 cites W2468925656 @default.
- W4308485570 cites W2513918579 @default.
- W4308485570 cites W2522054313 @default.
- W4308485570 cites W2549291642 @default.
- W4308485570 cites W2619206214 @default.
- W4308485570 cites W2714602397 @default.
- W4308485570 cites W2733238941 @default.
- W4308485570 cites W2734261046 @default.
- W4308485570 cites W2752512684 @default.
- W4308485570 cites W2763002867 @default.
- W4308485570 cites W2768841642 @default.
- W4308485570 cites W2770578696 @default.
- W4308485570 cites W2776666361 @default.
- W4308485570 cites W2782561387 @default.
- W4308485570 cites W2898752091 @default.
- W4308485570 cites W3024076981 @default.
- W4308485570 cites W3037016973 @default.
- W4308485570 cites W3042970220 @default.
- W4308485570 cites W3049748461 @default.