FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308486537> ?p ?o ?g. }

• W4308486537 endingPage "102531" @default.
• W4308486537 startingPage "102531" @default.
• W4308486537 abstract "In-vitro and animal studies demonstrate that epigenetic regulation may play an important role in lipid peroxidation. No human study to date has directly evaluated microRNAs (miRNAs), as epigenetic modulators, in relation to systemic levels of lipid peroxidation. To evaluate associations between systemic levels of lipid peroxidation and miRNA expression profiles in women. Included in the analysis were 92 women aged 40–70 years, a subset of the Shanghai Women’s Health Study (SWHS). Lipid peroxidation was assessed by urinary markers F2-isoprostanes (F2-IsoPs), the products of free radical-catalyzed peroxidation of arachidonic acid, and its major metabolite after β-oxidation, 2,3-dinor-5,6-dihydro-15-F2t-IsoP (F2-IsoP-M), with GC/NICI-MS assays. Expression levels of 798 miRNAs were quantified in peripheral plasma with NanoString nCounter assays. A multivariable linear regression model was used to examine the association between lipid peroxidation and miRNA expression. After adjusting for potential confounders, 29 miRNAs and 213 miRNAs were associated with F2-IsoPs and F2-IsoP-M, respectively. When further controlling for multiple comparisons, none of these nominally significant associations with F2-IsoPs was retained, whereas 71 of 213 miRNAs associated with F2-IsoP-M remained. The predicted targets of the F2-IsoP-M associated miRNAs were enriched for several lipid peroxidation-related processes such as PI3K/AKT, MAPK, FOXO and HIF-1 signaling pathways. Moreover, 10 miRNAs (miR-93-5p, miR-761, miR-301b-3p, miR-497-5p, miR-141-3p, miR-186-5p, miR-126-3p, miR-200b-3p, miR-520d-3p, and miR-363-3p) exhibited functional interactions with 50 unique mRNAs targets involved in the regulation of β-oxidation. To our knowledge, this study, for the first time, provides human data suggesting that miRNA expression may be linked to lipid peroxidation products and their metabolism." @default.
• W4308486537 created "2022-11-12" @default.
• W4308486537 creator A5005513706 @default.
• W4308486537 creator A5011155701 @default.
• W4308486537 creator A5040085389 @default.
• W4308486537 creator A5049096725 @default.
• W4308486537 creator A5050233317 @default.
• W4308486537 creator A5053149936 @default.
• W4308486537 creator A5074212737 @default.
• W4308486537 creator A5080361653 @default.
• W4308486537 creator A5084458604 @default.
• W4308486537 creator A5085657415 @default.
• W4308486537 creator A5086299976 @default.
• W4308486537 creator A5091859226 @default.
• W4308486537 date "2022-12-01" @default.
• W4308486537 modified "2023-10-03" @default.
• W4308486537 title "Association between lipid peroxidation biomarkers and microRNA expression profiles" @default.
• W4308486537 cites W1497264583 @default.
• W4308486537 cites W1895433496 @default.
• W4308486537 cites W1968839521 @default.
• W4308486537 cites W1972153352 @default.
• W4308486537 cites W1975608441 @default.
• W4308486537 cites W1995830102 @default.
• W4308486537 cites W1996922652 @default.
• W4308486537 cites W2000445173 @default.
• W4308486537 cites W2008566131 @default.
• W4308486537 cites W2009760859 @default.
• W4308486537 cites W2021492010 @default.
• W4308486537 cites W2024761791 @default.
• W4308486537 cites W2038656521 @default.
• W4308486537 cites W2046291314 @default.
• W4308486537 cites W2047929348 @default.
• W4308486537 cites W2047967134 @default.
• W4308486537 cites W2088648948 @default.
• W4308486537 cites W2089486469 @default.
• W4308486537 cites W2098360148 @default.
• W4308486537 cites W2100583514 @default.
• W4308486537 cites W2104806243 @default.
• W4308486537 cites W2105686255 @default.
• W4308486537 cites W2108732038 @default.
• W4308486537 cites W2110083175 @default.
• W4308486537 cites W2113446268 @default.
• W4308486537 cites W2122341467 @default.
• W4308486537 cites W2133968430 @default.
• W4308486537 cites W2135061646 @default.
• W4308486537 cites W2142552906 @default.
• W4308486537 cites W2146414563 @default.
• W4308486537 cites W2150912425 @default.
• W4308486537 cites W2161145604 @default.
• W4308486537 cites W2162674813 @default.
• W4308486537 cites W2167946477 @default.
• W4308486537 cites W2170784637 @default.
• W4308486537 cites W2174423712 @default.
• W4308486537 cites W2192600717 @default.
• W4308486537 cites W2559411119 @default.
• W4308486537 cites W2580955026 @default.
• W4308486537 cites W2791544532 @default.
• W4308486537 cites W2802436949 @default.
• W4308486537 cites W2886504687 @default.
• W4308486537 cites W2916689280 @default.
• W4308486537 cites W2973149747 @default.
• W4308486537 cites W3048615640 @default.
• W4308486537 cites W3169713332 @default.
• W4308486537 cites W4206978045 @default.
• W4308486537 cites W4210980327 @default.
• W4308486537 cites W4224943741 @default.
• W4308486537 doi "https://doi.org/10.1016/j.redox.2022.102531" @default.
• W4308486537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36335760" @default.
• W4308486537 hasPublicationYear "2022" @default.
• W4308486537 type Work @default.
• W4308486537 citedByCount "1" @default.
• W4308486537 countsByYear W43084865372023 @default.
• W4308486537 crossrefType "journal-article" @default.
• W4308486537 hasAuthorship W4308486537A5005513706 @default.
• W4308486537 hasAuthorship W4308486537A5011155701 @default.
• W4308486537 hasAuthorship W4308486537A5040085389 @default.
• W4308486537 hasAuthorship W4308486537A5049096725 @default.
• W4308486537 hasAuthorship W4308486537A5050233317 @default.
• W4308486537 hasAuthorship W4308486537A5053149936 @default.
• W4308486537 hasAuthorship W4308486537A5074212737 @default.
• W4308486537 hasAuthorship W4308486537A5080361653 @default.
• W4308486537 hasAuthorship W4308486537A5084458604 @default.
• W4308486537 hasAuthorship W4308486537A5085657415 @default.
• W4308486537 hasAuthorship W4308486537A5086299976 @default.
• W4308486537 hasAuthorship W4308486537A5091859226 @default.
• W4308486537 hasBestOaLocation W43084865372 @default.
• W4308486537 hasConcept C104317684 @default.
• W4308486537 hasConcept C126322002 @default.
• W4308486537 hasConcept C134018914 @default.
• W4308486537 hasConcept C145059251 @default.
• W4308486537 hasConcept C181199279 @default.
• W4308486537 hasConcept C185592680 @default.
• W4308486537 hasConcept C2776151105 @default.
• W4308486537 hasConcept C2778078955 @default.
• W4308486537 hasConcept C2780829032 @default.
• W4308486537 hasConcept C41091548 @default.
• W4308486537 hasConcept C55493867 @default.
• W4308486537 hasConcept C71924100 @default.

• next