FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308490106> ?p ?o ?g. }

• W4308490106 endingPage "148154" @default.
• W4308490106 startingPage "148154" @default.
• W4308490106 abstract "Pain management after oral surgeries is essential to enhance recovery, reduce negative outcomes and improve the experience of the patient. Naltrexone (NTX) is a non-selective opioid receptor antagonist that has been shown to modulate neuro-inflammation when employed in low to ultra-low doses. In addition, ultra-low dose naltrexone (ULDN) has been shown to potentiate opioids’ analgesia and to have opioid-sparing effects. Herein it was investigated the effect of ULDN in a model of postoperative orofacial pain in rats, and it was tested the hypothesis that blockade of TLR4-signalling pathway contributes to its antinociceptive effect. Systemic NTX reduced heat hyperalgesia in female rats and heat and mechanical hyperalgesia in male rats after incision surgery. Combined treatment with NTX and morphine, both at ineffective doses, resulted in a significant reduction of heat hyperalgesia in male rats. NTX injection at the incision site failed to change heat hyperalgesia, but injection at the trigeminal ganglion (TG) or subnucleus caudalis (Sp5C) caused a significant reduction in heat hyperalgesia. At these sites, blockade of TLR4 impeded NTX effect. Lipopolysaccharide (LPS) injection in the intraoral mucosa resulted in facial heat hyperalgesia an increase in IL-1β levels in the TG, which were reduced by systemic NTX. Stimulation of macrophages with LPS resulted in increase of nitric oxide, IL-1β and CXCL-2 levels which were reduced by NTX. Altogether, these results provide evidence for an antinociceptive effect of ULDN in postoperative orofacial pain and suggest that blockade of TLR4 and downstream signaling pathway contribute to its effect." @default.
• W4308490106 created "2022-11-12" @default.
• W4308490106 creator A5005282538 @default.
• W4308490106 creator A5007771868 @default.
• W4308490106 creator A5008275837 @default.
• W4308490106 creator A5016914455 @default.
• W4308490106 creator A5031346988 @default.
• W4308490106 creator A5087802013 @default.
• W4308490106 date "2023-01-01" @default.
• W4308490106 modified "2023-09-25" @default.
• W4308490106 title "Antinociceptive effect of ultra-low dose naltrexone in a pre-clinical model of postoperative orofacial pain" @default.
• W4308490106 cites W1850379830 @default.
• W4308490106 cites W1884157969 @default.
• W4308490106 cites W1967871273 @default.
• W4308490106 cites W1999249313 @default.
• W4308490106 cites W2000069076 @default.
• W4308490106 cites W2006700963 @default.
• W4308490106 cites W2024036962 @default.
• W4308490106 cites W2025416476 @default.
• W4308490106 cites W2029261820 @default.
• W4308490106 cites W2034088074 @default.
• W4308490106 cites W2039006502 @default.
• W4308490106 cites W2047288044 @default.
• W4308490106 cites W2077534408 @default.
• W4308490106 cites W2078895028 @default.
• W4308490106 cites W2087401044 @default.
• W4308490106 cites W2089451039 @default.
• W4308490106 cites W2093025928 @default.
• W4308490106 cites W2102262969 @default.
• W4308490106 cites W2103780725 @default.
• W4308490106 cites W2111425451 @default.
• W4308490106 cites W2113754496 @default.
• W4308490106 cites W2116348926 @default.
• W4308490106 cites W2126241051 @default.
• W4308490106 cites W2165305033 @default.
• W4308490106 cites W2412243856 @default.
• W4308490106 cites W2607401549 @default.
• W4308490106 cites W2607956998 @default.
• W4308490106 cites W2614588022 @default.
• W4308490106 cites W2621552279 @default.
• W4308490106 cites W2750588517 @default.
• W4308490106 cites W2766199515 @default.
• W4308490106 cites W2779250325 @default.
• W4308490106 cites W2781162593 @default.
• W4308490106 cites W2783404097 @default.
• W4308490106 cites W2790373104 @default.
• W4308490106 cites W2791477100 @default.
• W4308490106 cites W2806682189 @default.
• W4308490106 cites W2809042357 @default.
• W4308490106 cites W2920504957 @default.
• W4308490106 cites W2934010911 @default.
• W4308490106 cites W2996024705 @default.
• W4308490106 cites W3033665367 @default.
• W4308490106 cites W3036976859 @default.
• W4308490106 cites W3041063522 @default.
• W4308490106 cites W3048338010 @default.
• W4308490106 cites W3080827468 @default.
• W4308490106 cites W3093849878 @default.
• W4308490106 cites W3114865490 @default.
• W4308490106 cites W3162372818 @default.
• W4308490106 cites W3173653851 @default.
• W4308490106 cites W3202940101 @default.
• W4308490106 cites W4220897418 @default.
• W4308490106 cites W4241521103 @default.
• W4308490106 doi "https://doi.org/10.1016/j.brainres.2022.148154" @default.
• W4308490106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36335995" @default.
• W4308490106 hasPublicationYear "2023" @default.
• W4308490106 type Work @default.
• W4308490106 citedByCount "0" @default.
• W4308490106 crossrefType "journal-article" @default.
• W4308490106 hasAuthorship W4308490106A5005282538 @default.
• W4308490106 hasAuthorship W4308490106A5007771868 @default.
• W4308490106 hasAuthorship W4308490106A5008275837 @default.
• W4308490106 hasAuthorship W4308490106A5016914455 @default.
• W4308490106 hasAuthorship W4308490106A5031346988 @default.
• W4308490106 hasAuthorship W4308490106A5087802013 @default.
• W4308490106 hasConcept C126322002 @default.
• W4308490106 hasConcept C141071460 @default.
• W4308490106 hasConcept C15490471 @default.
• W4308490106 hasConcept C170493617 @default.
• W4308490106 hasConcept C2775962371 @default.
• W4308490106 hasConcept C2776070231 @default.
• W4308490106 hasConcept C2776914184 @default.
• W4308490106 hasConcept C2777972943 @default.
• W4308490106 hasConcept C2778468042 @default.
• W4308490106 hasConcept C2778750930 @default.
• W4308490106 hasConcept C2779245659 @default.
• W4308490106 hasConcept C2781063702 @default.
• W4308490106 hasConcept C2781463296 @default.
• W4308490106 hasConcept C42219234 @default.
• W4308490106 hasConcept C71924100 @default.
• W4308490106 hasConcept C98274493 @default.
• W4308490106 hasConceptScore W4308490106C126322002 @default.
• W4308490106 hasConceptScore W4308490106C141071460 @default.
• W4308490106 hasConceptScore W4308490106C15490471 @default.
• W4308490106 hasConceptScore W4308490106C170493617 @default.
• W4308490106 hasConceptScore W4308490106C2775962371 @default.
• W4308490106 hasConceptScore W4308490106C2776070231 @default.

• next