Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308490107> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4308490107 endingPage "160" @default.
- W4308490107 startingPage "155" @default.
- W4308490107 abstract "To assess treatment outcomes in patients with stage I/II extranodal NK-/T-cell lymphoma, nasal type (ENKTCL-NT) and the feasibility of low-dose radiotherapy (RT) for achieving complete response (CR, defined as showing no residual hypermetabolic uptake on positron emission tomography [PET] or no residual lesions on computed tomography [CT]) after l-asparaginase-containing chemotherapy (l-ASP).Between 1992 and 2018, 76 patients with early-stage ENKTCL-NT who achieved CR or partial response (PR) after induction chemotherapy received adjuvant RT. RT doses (using biologically equivalent doses in 2 Gy fractions [EQD2]) and rates of local recurrence-free survival (LRFS), locoregional recurrence-free survival (LRRFS), distant metastasis-free survival (DMFS), progression-free survival (PFS), and cancer-specific survival (CSS) were determined.Median follow-up was 5.1 years (range, 0.5-20.8). The median RT dose was 45 Gy (range, 20-54). The 5-year LRFS, LRRFS, DMFS, PFS, and CSS rates were 82.7 %, 78.2 %, 81.1 %, 68.7 %, and 84.4 %, respectively. CR after induction chemotherapy was notably linked to better survival outcomes across each endpoint. Survival outcomes were not affected either by the administration of l-ASP or EQD2 < 40 Gy in patients displaying CR after l-ASP. Adverse events (AEs) ≥ Grade 2 were significantly reduced with EQD2 < 40 Gy, compared with EQD2 ≥ 40 Gy.Achieving CR after chemotherapy was the most predictive factor of survival outcomes in early-stage ENKTCL-NT. Decreasing RT doses in patients with CR after l-ASP appeared to minimize the occurrence of AE without compromising LRR risk; however, longer follow-ups and cautious application are warranted." @default.
- W4308490107 created "2022-11-12" @default.
- W4308490107 creator A5008228126 @default.
- W4308490107 creator A5020761519 @default.
- W4308490107 creator A5058521062 @default.
- W4308490107 creator A5070098382 @default.
- W4308490107 creator A5074404916 @default.
- W4308490107 creator A5083120121 @default.
- W4308490107 date "2023-01-01" @default.
- W4308490107 modified "2023-09-26" @default.
- W4308490107 title "Feasibility of low-dose radiotherapy for patients with stage I/II extranodal NK-/T-cell lymphoma, nasal type achieving complete response after l-asparaginase-containing chemotherapy" @default.
- W4308490107 cites W2052164658 @default.
- W4308490107 cites W2070079220 @default.
- W4308490107 cites W2090821308 @default.
- W4308490107 cites W2091292251 @default.
- W4308490107 cites W2092939241 @default.
- W4308490107 cites W2113282595 @default.
- W4308490107 cites W2119147717 @default.
- W4308490107 cites W2121647828 @default.
- W4308490107 cites W2147729723 @default.
- W4308490107 cites W2316324732 @default.
- W4308490107 cites W2513393790 @default.
- W4308490107 cites W2526788348 @default.
- W4308490107 cites W2571034058 @default.
- W4308490107 cites W2595475163 @default.
- W4308490107 cites W2598700764 @default.
- W4308490107 cites W2726349956 @default.
- W4308490107 cites W2802699819 @default.
- W4308490107 cites W2889954811 @default.
- W4308490107 cites W2904793969 @default.
- W4308490107 cites W2928723313 @default.
- W4308490107 doi "https://doi.org/10.1016/j.ctro.2022.10.014" @default.
- W4308490107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36466747" @default.
- W4308490107 hasPublicationYear "2023" @default.
- W4308490107 type Work @default.
- W4308490107 citedByCount "0" @default.
- W4308490107 crossrefType "journal-article" @default.
- W4308490107 hasAuthorship W4308490107A5008228126 @default.
- W4308490107 hasAuthorship W4308490107A5020761519 @default.
- W4308490107 hasAuthorship W4308490107A5058521062 @default.
- W4308490107 hasAuthorship W4308490107A5070098382 @default.
- W4308490107 hasAuthorship W4308490107A5074404916 @default.
- W4308490107 hasAuthorship W4308490107A5083120121 @default.
- W4308490107 hasBestOaLocation W43084901073 @default.
- W4308490107 hasConcept C126322002 @default.
- W4308490107 hasConcept C126894567 @default.
- W4308490107 hasConcept C143998085 @default.
- W4308490107 hasConcept C146357865 @default.
- W4308490107 hasConcept C151730666 @default.
- W4308490107 hasConcept C2776694085 @default.
- W4308490107 hasConcept C2779338263 @default.
- W4308490107 hasConcept C2989005 @default.
- W4308490107 hasConcept C509974204 @default.
- W4308490107 hasConcept C71924100 @default.
- W4308490107 hasConcept C86803240 @default.
- W4308490107 hasConcept C90924648 @default.
- W4308490107 hasConceptScore W4308490107C126322002 @default.
- W4308490107 hasConceptScore W4308490107C126894567 @default.
- W4308490107 hasConceptScore W4308490107C143998085 @default.
- W4308490107 hasConceptScore W4308490107C146357865 @default.
- W4308490107 hasConceptScore W4308490107C151730666 @default.
- W4308490107 hasConceptScore W4308490107C2776694085 @default.
- W4308490107 hasConceptScore W4308490107C2779338263 @default.
- W4308490107 hasConceptScore W4308490107C2989005 @default.
- W4308490107 hasConceptScore W4308490107C509974204 @default.
- W4308490107 hasConceptScore W4308490107C71924100 @default.
- W4308490107 hasConceptScore W4308490107C86803240 @default.
- W4308490107 hasConceptScore W4308490107C90924648 @default.
- W4308490107 hasLocation W43084901071 @default.
- W4308490107 hasLocation W43084901072 @default.
- W4308490107 hasLocation W43084901073 @default.
- W4308490107 hasLocation W43084901074 @default.
- W4308490107 hasOpenAccess W4308490107 @default.
- W4308490107 hasPrimaryLocation W43084901071 @default.
- W4308490107 hasRelatedWork W1535958986 @default.
- W4308490107 hasRelatedWork W1987468340 @default.
- W4308490107 hasRelatedWork W2356105190 @default.
- W4308490107 hasRelatedWork W2376593068 @default.
- W4308490107 hasRelatedWork W2384708512 @default.
- W4308490107 hasRelatedWork W2387970634 @default.
- W4308490107 hasRelatedWork W2390264150 @default.
- W4308490107 hasRelatedWork W2404042595 @default.
- W4308490107 hasRelatedWork W2416632858 @default.
- W4308490107 hasRelatedWork W4220939315 @default.
- W4308490107 hasVolume "38" @default.
- W4308490107 isParatext "false" @default.
- W4308490107 isRetracted "false" @default.
- W4308490107 workType "article" @default.