Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308496880> ?p ?o ?g. }
- W4308496880 abstract "Abstract We evaluated whether whole-body dual-energy X-ray absorptiometry (DXA) measures of lean body mass can be used as biomarkers for disease progression and treatment effects in patients with Duchenne muscular dystrophy. This post hoc analysis utilized data from a randomized, 2-period study of domagrozumab versus placebo in 120 ambulatory boys with DMD. DXA measures of lean body mass were obtained from the whole body (excluding head), arms, legs and appendicular skeleton at baseline and every 16 weeks. Treatment effects on DXA measures for domagrozumab versus placebo were assessed at Week 49. At Week 49, domagrozumab statistically significantly increased lean body mass versus placebo in the appendicular skeleton ( p = 0.050) and arms ( p < 0.001). The relationship between lean body mass at Week 49 and functional endpoints at Week 97 was evaluated. Changes in lean body mass at Week 49 in all regions except arms were significantly correlated with percent change from baseline in 4-stair climb (4SC) at Week 97. DXA-derived percent lean mass at Week 49 also correlated with 4SC and North Star Ambulatory Assessment at Week 97. These data indicate that whole-body DXA measures can be used as biomarkers for treatment effects and disease progression in patients with DMD, and warrant further investigation. Trial registration : ClinicalTrials.gov, NCT02310763; registered 8 December 2014." @default.
- W4308496880 created "2022-11-12" @default.
- W4308496880 creator A5007427947 @default.
- W4308496880 creator A5012227405 @default.
- W4308496880 creator A5020829434 @default.
- W4308496880 creator A5024414333 @default.
- W4308496880 creator A5046308926 @default.
- W4308496880 creator A5062032887 @default.
- W4308496880 creator A5063362332 @default.
- W4308496880 creator A5078152396 @default.
- W4308496880 creator A5085970575 @default.
- W4308496880 creator A5087363192 @default.
- W4308496880 creator A5089234882 @default.
- W4308496880 date "2022-11-05" @default.
- W4308496880 modified "2023-10-14" @default.
- W4308496880 title "Dual-energy X-ray absorptiometry measures of lean body mass as a biomarker for progression in boys with Duchenne muscular dystrophy" @default.
- W4308496880 cites W1974926812 @default.
- W4308496880 cites W2031634153 @default.
- W4308496880 cites W2035041709 @default.
- W4308496880 cites W2041695177 @default.
- W4308496880 cites W2043489615 @default.
- W4308496880 cites W2045144063 @default.
- W4308496880 cites W2045802036 @default.
- W4308496880 cites W2074620127 @default.
- W4308496880 cites W2084369534 @default.
- W4308496880 cites W2108395079 @default.
- W4308496880 cites W2111961837 @default.
- W4308496880 cites W2148717854 @default.
- W4308496880 cites W2217065576 @default.
- W4308496880 cites W2234725241 @default.
- W4308496880 cites W2277280343 @default.
- W4308496880 cites W2424490565 @default.
- W4308496880 cites W2507871962 @default.
- W4308496880 cites W2532593119 @default.
- W4308496880 cites W2753097429 @default.
- W4308496880 cites W2767436720 @default.
- W4308496880 cites W2784812244 @default.
- W4308496880 cites W2784934916 @default.
- W4308496880 cites W2784992484 @default.
- W4308496880 cites W2788777662 @default.
- W4308496880 cites W2965651703 @default.
- W4308496880 cites W2998459048 @default.
- W4308496880 cites W3010225431 @default.
- W4308496880 cites W3028584612 @default.
- W4308496880 cites W3030480398 @default.
- W4308496880 cites W3048868331 @default.
- W4308496880 cites W3092216066 @default.
- W4308496880 cites W3093931004 @default.
- W4308496880 cites W3119377901 @default.
- W4308496880 cites W3131782536 @default.
- W4308496880 cites W3166174049 @default.
- W4308496880 cites W4223440166 @default.
- W4308496880 doi "https://doi.org/10.1038/s41598-022-23072-5" @default.
- W4308496880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36335191" @default.
- W4308496880 hasPublicationYear "2022" @default.
- W4308496880 type Work @default.
- W4308496880 citedByCount "6" @default.
- W4308496880 countsByYear W43084968802023 @default.
- W4308496880 crossrefType "journal-article" @default.
- W4308496880 hasAuthorship W4308496880A5007427947 @default.
- W4308496880 hasAuthorship W4308496880A5012227405 @default.
- W4308496880 hasAuthorship W4308496880A5020829434 @default.
- W4308496880 hasAuthorship W4308496880A5024414333 @default.
- W4308496880 hasAuthorship W4308496880A5046308926 @default.
- W4308496880 hasAuthorship W4308496880A5062032887 @default.
- W4308496880 hasAuthorship W4308496880A5063362332 @default.
- W4308496880 hasAuthorship W4308496880A5078152396 @default.
- W4308496880 hasAuthorship W4308496880A5085970575 @default.
- W4308496880 hasAuthorship W4308496880A5087363192 @default.
- W4308496880 hasAuthorship W4308496880A5089234882 @default.
- W4308496880 hasBestOaLocation W43084968801 @default.
- W4308496880 hasConcept C120863210 @default.
- W4308496880 hasConcept C126322002 @default.
- W4308496880 hasConcept C126894567 @default.
- W4308496880 hasConcept C142724271 @default.
- W4308496880 hasConcept C147583825 @default.
- W4308496880 hasConcept C1862650 @default.
- W4308496880 hasConcept C204787440 @default.
- W4308496880 hasConcept C27081682 @default.
- W4308496880 hasConcept C2776541429 @default.
- W4308496880 hasConcept C2776886416 @default.
- W4308496880 hasConcept C2778943923 @default.
- W4308496880 hasConcept C2781440623 @default.
- W4308496880 hasConcept C2989005 @default.
- W4308496880 hasConcept C35785553 @default.
- W4308496880 hasConcept C71924100 @default.
- W4308496880 hasConceptScore W4308496880C120863210 @default.
- W4308496880 hasConceptScore W4308496880C126322002 @default.
- W4308496880 hasConceptScore W4308496880C126894567 @default.
- W4308496880 hasConceptScore W4308496880C142724271 @default.
- W4308496880 hasConceptScore W4308496880C147583825 @default.
- W4308496880 hasConceptScore W4308496880C1862650 @default.
- W4308496880 hasConceptScore W4308496880C204787440 @default.
- W4308496880 hasConceptScore W4308496880C27081682 @default.
- W4308496880 hasConceptScore W4308496880C2776541429 @default.
- W4308496880 hasConceptScore W4308496880C2776886416 @default.
- W4308496880 hasConceptScore W4308496880C2778943923 @default.
- W4308496880 hasConceptScore W4308496880C2781440623 @default.
- W4308496880 hasConceptScore W4308496880C2989005 @default.
- W4308496880 hasConceptScore W4308496880C35785553 @default.