Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308498512> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4308498512 endingPage "714" @default.
- W4308498512 startingPage "709" @default.
- W4308498512 abstract "5-Fluorouracil (5FU) is a commonly used anticancer drug. However, the severe oral mucositis induced by 5FU in about 60-70% of patients was a major cause of discontinuous therapy. Since oral dysbiosis induced by 5FU was well correlated with severity of oral mucositis and Porphyromonas gingivalis (P.g.) was a keystone pathogen of dysbiosis. Thus, in this study, we aimed to explore the novel regimens of 5FU combined with phytopolyphenols (curcumin, green tea polyphenols) as well as ZnSO4 on antibacterial effects of cultured P.g. growth. In addition, similar regimens containing thioridazine (TRZ) were also tested for their antibacterial efficacy.The synergistic (Combination Index (CI) < 1) antiproliferation and anti-protease efficacies (IC50) of novel regimens on cultured P.g. were evaluated by OD600 and colorimetric method respectively.The results obtained indicated that both novel regimens of 5FU and TRZ exhibited potent synergistic antibacterial effects against growth and protease of P.g.These novel regimens of 5-FU and TRZ were potent antibacterial agents which merit for further preclinical and clinical trials in management of oral mucositis, cancers and infectious diseases." @default.
- W4308498512 created "2022-11-12" @default.
- W4308498512 creator A5041417481 @default.
- W4308498512 creator A5043730081 @default.
- W4308498512 creator A5051987317 @default.
- W4308498512 date "2023-04-01" @default.
- W4308498512 modified "2023-10-18" @default.
- W4308498512 title "Synergistic antibacterial effects of 5-fluorouracil or thioridazine in combination with phytopolyphenols on cultured Porphyromonas gingivalis" @default.
- W4308498512 cites W1982739580 @default.
- W4308498512 cites W2005633976 @default.
- W4308498512 cites W2096439168 @default.
- W4308498512 cites W2103664457 @default.
- W4308498512 cites W2105408725 @default.
- W4308498512 cites W2130887432 @default.
- W4308498512 cites W2172122060 @default.
- W4308498512 cites W2294666440 @default.
- W4308498512 cites W2531115510 @default.
- W4308498512 cites W2588563984 @default.
- W4308498512 cites W2592084636 @default.
- W4308498512 cites W2725376611 @default.
- W4308498512 cites W2803047937 @default.
- W4308498512 cites W2890582054 @default.
- W4308498512 cites W2946928795 @default.
- W4308498512 cites W2995336135 @default.
- W4308498512 cites W2996132655 @default.
- W4308498512 cites W3009468562 @default.
- W4308498512 cites W3094522698 @default.
- W4308498512 cites W3120006517 @default.
- W4308498512 cites W3127025230 @default.
- W4308498512 cites W32597207 @default.
- W4308498512 cites W4220686179 @default.
- W4308498512 cites W4223965724 @default.
- W4308498512 cites W4280582841 @default.
- W4308498512 cites W45787623 @default.
- W4308498512 doi "https://doi.org/10.1016/j.jds.2022.10.026" @default.
- W4308498512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37021224" @default.
- W4308498512 hasPublicationYear "2023" @default.
- W4308498512 type Work @default.
- W4308498512 citedByCount "0" @default.
- W4308498512 crossrefType "journal-article" @default.
- W4308498512 hasAuthorship W4308498512A5041417481 @default.
- W4308498512 hasAuthorship W4308498512A5043730081 @default.
- W4308498512 hasAuthorship W4308498512A5051987317 @default.
- W4308498512 hasBestOaLocation W43084985121 @default.
- W4308498512 hasConcept C126322002 @default.
- W4308498512 hasConcept C2776694085 @default.
- W4308498512 hasConcept C2777165150 @default.
- W4308498512 hasConcept C2778496288 @default.
- W4308498512 hasConcept C2779134260 @default.
- W4308498512 hasConcept C2780104969 @default.
- W4308498512 hasConcept C2780183776 @default.
- W4308498512 hasConcept C2780385504 @default.
- W4308498512 hasConcept C523546767 @default.
- W4308498512 hasConcept C54355233 @default.
- W4308498512 hasConcept C71924100 @default.
- W4308498512 hasConcept C86803240 @default.
- W4308498512 hasConcept C98274493 @default.
- W4308498512 hasConceptScore W4308498512C126322002 @default.
- W4308498512 hasConceptScore W4308498512C2776694085 @default.
- W4308498512 hasConceptScore W4308498512C2777165150 @default.
- W4308498512 hasConceptScore W4308498512C2778496288 @default.
- W4308498512 hasConceptScore W4308498512C2779134260 @default.
- W4308498512 hasConceptScore W4308498512C2780104969 @default.
- W4308498512 hasConceptScore W4308498512C2780183776 @default.
- W4308498512 hasConceptScore W4308498512C2780385504 @default.
- W4308498512 hasConceptScore W4308498512C523546767 @default.
- W4308498512 hasConceptScore W4308498512C54355233 @default.
- W4308498512 hasConceptScore W4308498512C71924100 @default.
- W4308498512 hasConceptScore W4308498512C86803240 @default.
- W4308498512 hasConceptScore W4308498512C98274493 @default.
- W4308498512 hasIssue "2" @default.
- W4308498512 hasLocation W43084985121 @default.
- W4308498512 hasLocation W43084985122 @default.
- W4308498512 hasLocation W43084985123 @default.
- W4308498512 hasOpenAccess W4308498512 @default.
- W4308498512 hasPrimaryLocation W43084985121 @default.
- W4308498512 hasRelatedWork W1571823809 @default.
- W4308498512 hasRelatedWork W1908190230 @default.
- W4308498512 hasRelatedWork W2169732730 @default.
- W4308498512 hasRelatedWork W2768273196 @default.
- W4308498512 hasRelatedWork W2983576537 @default.
- W4308498512 hasRelatedWork W3015755119 @default.
- W4308498512 hasRelatedWork W3020104645 @default.
- W4308498512 hasRelatedWork W3167469682 @default.
- W4308498512 hasRelatedWork W3197364695 @default.
- W4308498512 hasRelatedWork W4224289096 @default.
- W4308498512 hasVolume "18" @default.
- W4308498512 isParatext "false" @default.
- W4308498512 isRetracted "false" @default.
- W4308498512 workType "article" @default.