FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308498672> ?p ?o ?g. }

• W4308498672 endingPage "39" @default.
• W4308498672 startingPage "34" @default.
• W4308498672 abstract "Chorioamnionitis is present in up to 70% of spontaneous preterm births and is associated with poor maternal, fetal and neonatal outcomes.ObjectiveTo explore the relationship between the neutrophil-to-lymphocyte ratio and histological chorioamnionitis in women who delivered preterm with no clinical signs or symptoms of infection.Study designThis was a retrospective analysis of a cohort of women who delivered spontaneously between 16 and 36+6 weeks at a tertiary UK hospital. Only women with placental histology and no signs of clinical infection were included. The neutrophil-to-lymphocyte ratio was calculated from a full blood count sample taken routinely within 24 h of delivery. The neutrophil-to-lymphocyte ratio was also calculated from first trimester booking bloods (<13 + 6 weeks) in a subgroup. Placental histopathology was categorised as either inflammatory (i.e. histologic chorioamnionitis, with or without evidence of fetal inflammatory response) or non-inflammatory (vascular pathology or a normal placenta).Results169 women had available placental pathology and were included in the analysis. 70 % (118/169) had confirmed placental inflammation. The mean neutrophil-to-lymphocyte ratio was significantly raised in this group compared to those with normal (n = 24) or vascular (n = 27) pathology (inflammatory neutrophil-to-lymphocyte ratio 9.81 vs non-inflammatory neutrophil-to-lymphocyte ratio 6.53, p = 0.002.The delivery neutrophil-to-lymphocyte ratio had an area under the receiver operating characteristic curve of 0.69 (0.60 to 0.78) for predicting placental inflammation. A raised neutrophil-to-lymphocyte ratio (>6) was associated with an odds ratio of 5.2 (95 % CI 2.55 to 10.56) for histological chorioamnionitis, with a sensitivity of 80 % and negative predictive value of 86 %. A higher cut-off of 9 had a negative predictive value of 79 % for fetal inflammatory response.ConclusionsA raised neutrophil-to-lymphocyte ratio is associated with a 5-fold increased risk of histological chorioamnionitis in women who delivered early without signs or symptoms of infection. It was also raised at the time of preterm labour compared to the first trimester. A full blood count is an almost universal investigation in women admitted in preterm labour, often repeated, making this inexpensive and non-invasive ratio a useful additional antenatal biomarker in women admitted in spontaneous preterm labour at risk of subclinical chorioamnionitis and its associated poor outcomes." @default.
• W4308498672 created "2022-11-12" @default.
• W4308498672 creator A5000629077 @default.
• W4308498672 creator A5000992391 @default.
• W4308498672 creator A5032620164 @default.
• W4308498672 creator A5050230897 @default.
• W4308498672 creator A5075686044 @default.
• W4308498672 date "2023-01-01" @default.
• W4308498672 modified "2023-09-25" @default.
• W4308498672 title "The neutrophil-to-lymphocyte ratio: A low-cost antenatal indicator of placental chorioamnionitis in women who deliver preterm without clinical signs and symptoms of infection" @default.
• W4308498672 cites W1483058388 @default.
• W4308498672 cites W1851428995 @default.
• W4308498672 cites W1873561454 @default.
• W4308498672 cites W1893553316 @default.
• W4308498672 cites W1970185637 @default.
• W4308498672 cites W1973709488 @default.
• W4308498672 cites W1975755498 @default.
• W4308498672 cites W2051868855 @default.
• W4308498672 cites W2095754714 @default.
• W4308498672 cites W2340049575 @default.
• W4308498672 cites W2411998436 @default.
• W4308498672 cites W2792604462 @default.
• W4308498672 cites W2896253926 @default.
• W4308498672 cites W2905058562 @default.
• W4308498672 cites W3202258270 @default.
• W4308498672 cites W4243140277 @default.
• W4308498672 cites W4281686334 @default.
• W4308498672 doi "https://doi.org/10.1016/j.ejogrb.2022.11.003" @default.
• W4308498672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36395744" @default.
• W4308498672 hasPublicationYear "2023" @default.
• W4308498672 type Work @default.
• W4308498672 citedByCount "0" @default.
• W4308498672 crossrefType "journal-article" @default.
• W4308498672 hasAuthorship W4308498672A5000629077 @default.
• W4308498672 hasAuthorship W4308498672A5000992391 @default.
• W4308498672 hasAuthorship W4308498672A5032620164 @default.
• W4308498672 hasAuthorship W4308498672A5050230897 @default.
• W4308498672 hasAuthorship W4308498672A5075686044 @default.
• W4308498672 hasBestOaLocation W43084986721 @default.
• W4308498672 hasConcept C126322002 @default.
• W4308498672 hasConcept C131872663 @default.
• W4308498672 hasConcept C156957248 @default.
• W4308498672 hasConcept C172680121 @default.
• W4308498672 hasConcept C203014093 @default.
• W4308498672 hasConcept C2776953305 @default.
• W4308498672 hasConcept C2777629866 @default.
• W4308498672 hasConcept C2777761686 @default.
• W4308498672 hasConcept C2777802486 @default.
• W4308498672 hasConcept C2778963024 @default.
• W4308498672 hasConcept C2779234561 @default.
• W4308498672 hasConcept C54355233 @default.
• W4308498672 hasConcept C71924100 @default.
• W4308498672 hasConcept C86803240 @default.
• W4308498672 hasConceptScore W4308498672C126322002 @default.
• W4308498672 hasConceptScore W4308498672C131872663 @default.
• W4308498672 hasConceptScore W4308498672C156957248 @default.
• W4308498672 hasConceptScore W4308498672C172680121 @default.
• W4308498672 hasConceptScore W4308498672C203014093 @default.
• W4308498672 hasConceptScore W4308498672C2776953305 @default.
• W4308498672 hasConceptScore W4308498672C2777629866 @default.
• W4308498672 hasConceptScore W4308498672C2777761686 @default.
• W4308498672 hasConceptScore W4308498672C2777802486 @default.
• W4308498672 hasConceptScore W4308498672C2778963024 @default.
• W4308498672 hasConceptScore W4308498672C2779234561 @default.
• W4308498672 hasConceptScore W4308498672C54355233 @default.
• W4308498672 hasConceptScore W4308498672C71924100 @default.
• W4308498672 hasConceptScore W4308498672C86803240 @default.
• W4308498672 hasFunder F4320319990 @default.
• W4308498672 hasFunder F4320320034 @default.
• W4308498672 hasFunder F4320335838 @default.
• W4308498672 hasFunder F4320336800 @default.
• W4308498672 hasLocation W43084986721 @default.
• W4308498672 hasLocation W43084986722 @default.
• W4308498672 hasOpenAccess W4308498672 @default.
• W4308498672 hasPrimaryLocation W43084986721 @default.
• W4308498672 hasRelatedWork W11399465 @default.
• W4308498672 hasRelatedWork W204821199 @default.
• W4308498672 hasRelatedWork W2056752164 @default.
• W4308498672 hasRelatedWork W2081213303 @default.
• W4308498672 hasRelatedWork W2416190606 @default.
• W4308498672 hasRelatedWork W2809225164 @default.
• W4308498672 hasRelatedWork W3118380457 @default.
• W4308498672 hasRelatedWork W4285064608 @default.
• W4308498672 hasRelatedWork W4308498672 @default.
• W4308498672 hasRelatedWork W3131872379 @default.
• W4308498672 hasVolume "280" @default.
• W4308498672 isParatext "false" @default.
• W4308498672 isRetracted "false" @default.
• W4308498672 workType "article" @default.