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• W4308507941 abstract "Tuberculosis is unusual among bacterial diseases in that treatments which can rapidly resolve symptoms do not predictably lead to a durable cure unless treatment is continued for months after all clinical and microbiological signs of disease have been eradicated. Using a novel steady-state antibiotic exposure system combined with chromosomal barcoding, we identified small hidden Mycobacterium tuberculosis subpopulations that repeatedly enter a state of drug tolerance with a predisposition to develop fixed drug resistance after first developing a cloud of unfixed resistance mutations." @default.
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• W4308507941 date "2022-12-20" @default.
• W4308507941 modified "2023-10-18" @default.
• W4308507941 title "Origin and Dynamics of Mycobacterium tuberculosis Subpopulations That Predictably Generate Drug Tolerance and Resistance" @default.
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• W4308507941 doi "https://doi.org/10.1128/mbio.02795-22" @default.
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