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• W4308512184 endingPage "13651" @default.
• W4308512184 startingPage "13651" @default.
• W4308512184 abstract "This study aimed to discover the immunomodulatory effect of selenium nanoparticles (SeNPs) on the functional state of neutrophils in vivo. Intraperitoneal injections of SeNPs (size 100 nm) 2.5 mg/kg/daily to BALB/c mice for a duration of 7-28 days led to the development of an inflammatory reaction, which was registered by a significant increase in the number of neutrophils released from the peritoneal cavity, as well as their activated state, without additional effects. At the same time, subcutaneous injections of the same SeNPs preparations at concentrations of 0.1, 0.5, and 2.5 mg/kg, on the contrary, modulated the functional state of neutrophils depending on the concentration and duration of SeNPs administration. With the use of fluorescence spectroscopy, chemiluminescence, biochemical methods, and PCR analysis, it was found that subcutaneous administration of SeNPs (0.1, 0.5, and 2.5 mg/kg) to mice for a short period of time (7-14 days) leads to modification of important neutrophil functions (adhesion, the number of migrating cells into the peritoneal cell cavity, ROS production, and NET formation). The obtained results indicated the immunostimulatory and antioxidant effects of SeNPs in vivo during short-term administration, while the most pronounced immunomodulatory effects of SeNPs were observed with the introduction of a low concentration of SeNPs (0.1 mg/kg). Increase in the administration time of SeNPs (0.1 mg/kg or 2.5 mg/kg) up to 28 days led to a decrease in the adhesive abilities of neutrophils and suppression of the expression of mRNA of adhesive molecules, as well as proteins involved in the generation of ROS, with the exception of NOX2; there was a tendency to suppress gene expression pro-inflammatory factors, which indicates the possible manifestation of immunosuppressive and anti-inflammatory effects of SeNPs during their long-term administration. Changes in the expression of selenoproteins also had features depending on the concentration and duration of the administered SeNPs. Selenoprotein P, selenoprotein M, selenoprotein S, selenoprotein K, and selenoprotein T were the most sensitive to the introduction of SeNPs into the mouse organism, which indicates their participation in maintaining the functional status of neutrophils, and possibly mediated the immunomodulatory effect of SeNPs." @default.
• W4308512184 created "2022-11-12" @default.
• W4308512184 creator A5000874785 @default.
• W4308512184 creator A5002847729 @default.
• W4308512184 creator A5060175815 @default.
• W4308512184 date "2022-11-07" @default.
• W4308512184 modified "2023-10-04" @default.
• W4308512184 title "Modulation of the Functional State of Mouse Neutrophils by Selenium Nanoparticles In Vivo" @default.
• W4308512184 cites W1600560134 @default.
• W4308512184 cites W1974948897 @default.
• W4308512184 cites W1986779275 @default.
• W4308512184 cites W1989678032 @default.
• W4308512184 cites W1993899840 @default.
• W4308512184 cites W1996518419 @default.
• W4308512184 cites W1996762559 @default.
• W4308512184 cites W1997092240 @default.
• W4308512184 cites W1998915656 @default.
• W4308512184 cites W2007177454 @default.
• W4308512184 cites W2009742078 @default.
• W4308512184 cites W2011581625 @default.
• W4308512184 cites W2013131201 @default.
• W4308512184 cites W2017496798 @default.
• W4308512184 cites W2019210852 @default.
• W4308512184 cites W2019756116 @default.
• W4308512184 cites W2032227357 @default.
• W4308512184 cites W2035809865 @default.
• W4308512184 cites W2047552874 @default.
• W4308512184 cites W2047765480 @default.
• W4308512184 cites W2049559464 @default.
• W4308512184 cites W2052770728 @default.
• W4308512184 cites W2072862372 @default.
• W4308512184 cites W2082676436 @default.
• W4308512184 cites W2084141237 @default.
• W4308512184 cites W2084670809 @default.
• W4308512184 cites W2087820683 @default.
• W4308512184 cites W2094666434 @default.
• W4308512184 cites W2108367388 @default.
• W4308512184 cites W2111397989 @default.
• W4308512184 cites W2118745476 @default.
• W4308512184 cites W2123859071 @default.
• W4308512184 cites W2125865950 @default.
• W4308512184 cites W2127704524 @default.
• W4308512184 cites W2135284986 @default.
• W4308512184 cites W2136854980 @default.
• W4308512184 cites W2144771445 @default.
• W4308512184 cites W2151629753 @default.
• W4308512184 cites W2159913536 @default.
• W4308512184 cites W2217988717 @default.
• W4308512184 cites W2260435250 @default.
• W4308512184 cites W2290459881 @default.
• W4308512184 cites W2302730120 @default.
• W4308512184 cites W2401758076 @default.
• W4308512184 cites W2407755011 @default.
• W4308512184 cites W2413235740 @default.
• W4308512184 cites W2414132905 @default.
• W4308512184 cites W2416355330 @default.
• W4308512184 cites W2416935187 @default.
• W4308512184 cites W2520404174 @default.
• W4308512184 cites W2560685789 @default.
• W4308512184 cites W2571033890 @default.
• W4308512184 cites W2571406302 @default.
• W4308512184 cites W2589710763 @default.
• W4308512184 cites W2607572711 @default.
• W4308512184 cites W2759326409 @default.
• W4308512184 cites W2762816177 @default.
• W4308512184 cites W2782959446 @default.
• W4308512184 cites W2786336204 @default.
• W4308512184 cites W2796973106 @default.
• W4308512184 cites W2797315709 @default.
• W4308512184 cites W2801781482 @default.
• W4308512184 cites W2804065490 @default.
• W4308512184 cites W2889290358 @default.
• W4308512184 cites W2890594432 @default.
• W4308512184 cites W2897195878 @default.
• W4308512184 cites W2900939282 @default.
• W4308512184 cites W2907953986 @default.
• W4308512184 cites W2909168900 @default.
• W4308512184 cites W2925230746 @default.
• W4308512184 cites W2947689706 @default.
• W4308512184 cites W2952553905 @default.
• W4308512184 cites W2952812933 @default.
• W4308512184 cites W2971802501 @default.
• W4308512184 cites W2990871864 @default.
• W4308512184 cites W2992792893 @default.
• W4308512184 cites W3003630737 @default.
• W4308512184 cites W3006446150 @default.
• W4308512184 cites W3010311908 @default.
• W4308512184 cites W3015611293 @default.
• W4308512184 cites W3015931936 @default.
• W4308512184 cites W3016802219 @default.
• W4308512184 cites W3021298627 @default.
• W4308512184 cites W3033921980 @default.
• W4308512184 cites W3044463005 @default.
• W4308512184 cites W3081552560 @default.
• W4308512184 cites W3094172744 @default.
• W4308512184 cites W3104355850 @default.
• W4308512184 cites W3116244094 @default.
• W4308512184 cites W3126670612 @default.

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